Cadherin-11 is a protein that in humans is encoded by the CDH11gene.[5][6]
Function
This gene encodes a type II classical cadherin from the cadherin superfamily, integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Mature cadherin proteins are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. Type II (atypical) cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I cadherins. Expression of this particular cadherin in osteoblastic cell lines, and its upregulation during differentiation, suggests a specific function in bone development and maintenance.[6] The mammalian CDH-11 homologues are termed calsyntenin.[7]
Relevance to cancer
CDH11 is overexpressed in 15% of breast cancers and seems essential to tumour progression in some other cancer types.[8][9]
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Kremmidiotis G, Baker E, Crawford J, Eyre HJ, Nahmias J, Callen DF (Aug 1998). "Localization of human cadherin genes to chromosome regions exhibiting cancer-related loss of heterozygosity". Genomics. 49 (3): 467–71. doi:10.1006/geno.1998.5281. PMID9615235.
Tanihara H, Sano K, Heimark RL, St John T, Suzuki S (1995). "Cloning of five human cadherins clarifies characteristic features of cadherin extracellular domain and provides further evidence for two structurally different types of cadherin". Cell Adhes. Commun. 2 (1): 15–26. doi:10.3109/15419069409014199. PMID7982033.
Pishvaian MJ, Feltes CM, Thompson P, Bussemakers MJ, Schalken JA, Byers SW (1999). "Cadherin-11 is expressed in invasive breast cancer cell lines". Cancer Res. 59 (4): 947–52. PMID10029089.
Braungart E, Hartman E, Bechler K, Höfler H, Atkinson MJ (2002). "The intracellular domain of cadherin-11 is not required for the induction of cell aggregation, adhesion or gap-junction formation". Cell Commun. Adhes. 8 (1): 15–27. doi:10.3109/15419060109080704. PMID11775026. S2CID23322445.
Morimoto AM, Tan N, West K, McArthur G, Toner GC, Manning WC, Smolich BD, Cherrington JM (2004). "Gene expression profiling of human colon xenograft tumors following treatment with SU11248, a multitargeted tyrosine kinase inhibitor". Oncogene. 23 (8): 1618–26. doi:10.1038/sj.onc.1207268. PMID14985702. S2CID23251484.