Protein-coding gene in the species Homo sapiens
Serine/threonine-protein kinase TAO1 is an enzyme that in humans is encoded by the TAOK1 gene .[5] [6] [7]
Clinical significance
Mutations of the TAOK1 gene cause developmental delay with or without intellectual impairment or behavioral abnormalities (DDIB), a condition first described in 2019.
References
^ a b c GRCh38: Ensembl release 89: ENSG00000160551 – Ensembl , May 2017
^ a b c GRCm38: Ensembl release 89: ENSMUSG00000017291 – Ensembl , May 2017
^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Nagase T, Kikuno R, Ishikawa KI, Hirosawa M, Ohara O (Apr 2000). "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro" . DNA Res . 7 (1): 65–73. doi :10.1093/dnares/7.1.65 . PMID 10718198 .
^ Timm T, Li XY, Biernat J, Jiao J, Mandelkow E, Vandekerckhove J, Mandelkow EM (Sep 2003). "MARKK, a Ste20-like kinase, activates the polarity-inducing kinase MARK/PAR-1" . EMBO J . 22 (19): 5090–101. doi :10.1093/emboj/cdg447 . PMC 204455 . PMID 14517247 .
^ "Entrez Gene: TAOK1 TAO kinase 1" .
Further reading
Hutchison M, Berman KS, Cobb MH (1998). "Isolation of TAO1, a protein kinase that activates MEKs in stress-activated protein kinase cascades" . J. Biol. Chem . 273 (44): 28625–32. doi :10.1074/jbc.273.44.28625 . PMID 9786855 .
Chen Z, Hutchison M, Cobb MH (1999). "Isolation of the protein kinase TAO2 and identification of its mitogen-activated protein kinase/extracellular signal-regulated kinase kinase binding domain" . J. Biol. Chem . 274 (40): 28803–7. doi :10.1074/jbc.274.40.28803 . PMID 10497253 .
Dias Neto E, Correa RG, Verjovski-Almeida S, et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags" . Proc. Natl. Acad. Sci. U.S.A . 97 (7): 3491–6. Bibcode :2000PNAS...97.3491D . doi :10.1073/pnas.97.7.3491 . PMC 16267 . PMID 10737800 .
Wistow G, Bernstein SL, Wyatt MK, et al. (2002). "Expressed sequence tag analysis of human RPE/choroid for the NEIBank Project: over 6000 non-redundant transcripts, novel genes and splice variants". Mol. Vis . 8 : 205–20. PMID 12107410 .
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 . PMC 139241 . PMID 12477932 .
Yustein JT, Xia L, Kahlenburg JM, et al. (2003). "Comparative studies of a new subfamily of human Ste20-like kinases: homodimerization, subcellular localization, and selective activation of MKK3 and p38" . Oncogene . 22 (40): 6129–41. doi :10.1038/sj.onc.1206605 . PMID 13679851 .
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs" . Nat. Genet . 36 (1): 40–5. doi :10.1038/ng1285 . PMID 14702039 .
Lizcano JM, Göransson O, Toth R, et al. (2005). "LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1" . EMBO J . 23 (4): 833–43. doi :10.1038/sj.emboj.7600110 . PMC 381014 . PMID 14976552 .
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins" . Proc. Natl. Acad. Sci. U.S.A . 101 (33): 12130–5. Bibcode :2004PNAS..10112130B . doi :10.1073/pnas.0404720101 . PMC 514446 . PMID 15302935 .
Zihni C, Mitsopoulos C, Tavares IA, et al. (2006). "Prostate-derived sterile 20-like kinase 2 (PSK2) regulates apoptotic morphology via C-Jun N-terminal kinase and Rho kinase-1" . J. Biol. Chem . 281 (11): 7317–23. doi :10.1074/jbc.M513769200 . PMID 16407310 .
Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol . 24 (10): 1285–92. doi :10.1038/nbt1240 . PMID 16964243 . S2CID 14294292 .
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks" . Cell . 127 (3): 635–48. doi :10.1016/j.cell.2006.09.026 . PMID 17081983 . S2CID 7827573 .
Raman M, Earnest S, Zhang K, et al. (2007). "TAO kinases mediate activation of p38 in response to DNA damage" . EMBO J . 26 (8): 2005–14. doi :10.1038/sj.emboj.7601668 . PMC 1852793 . PMID 17396146 .
Draviam VM, Stegmeier F, Nalepa G, et al. (2007). "A functional genomic screen identifies a role for TAO1 kinase in spindle-checkpoint signalling". Nat. Cell Biol . 9 (5): 556–64. doi :10.1038/ncb1569 . PMID 17417629 . S2CID 34976750 .