Monoclonal antibody | |
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Type | Whole antibody |
Source | Humanized (from mouse) |
Target | E. coli Shiga-like toxin II B subunit |
Clinical data | |
ATC code |
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Identifiers | |
CAS Number | |
ChemSpider |
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UNII | |
Chemical and physical data | |
Formula | C6414H9934N1718O2010S40 |
Molar mass | 144556.44 g·mol−1 |
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Urtoxazumab is a humanized monoclonal antibody against diarrhoea caused by Escherichia coli, serotype O121. The drug is designed to bind to a toxin of this bacterium, so that it can be more easily broken down and eliminated from the body.[1][2]
References
- ^ "International Nonproprietary Names for Pharmaceutical Substances (INN)" (PDF). World Health Organization.
- ^ López EL, Contrini MM, Glatstein E, González Ayala S, Santoro R, Allende D, et al. (January 2010). "Safety and pharmacokinetics of urtoxazumab, a humanized monoclonal antibody, against Shiga-like toxin 2 in healthy adults and in pediatric patients infected with Shiga-like toxin-producing Escherichia coli". Antimicrobial Agents and Chemotherapy. 54 (1): 239–43. doi:10.1128/AAC.00343-09. PMC 2798559. PMID 19822704.