Protein-coding gene in humans
Inositol 1,4,5-trisphosphate receptor, type 2 , also known as ITPR2 , is a protein which in humans is encoded by the ITPR2 gene .[ 5] The protein encoded by this gene is both a receptor for inositol triphosphate and a calcium channel .[ 6]
See also
References
Further reading
Jardín I, Lápez JJ, Salido GM, Rosado JA (2008). "Functional relevance of the de novo coupling between hTRPC1 and type II IP3 receptor in store-operated Ca2+ entry in human platelets". Cell. Signal . 20 (4): 737–47. doi :10.1016/j.cellsig.2007.12.010 . PMID 18249094 .
Wilker E, Mittleman MA, Litonjua AA, et al. (2009). "Postural changes in blood pressure associated with interactions between candidate genes for chronic respiratory diseases and exposure to particulate matter" . Environ. Health Perspect . 117 (6): 935–40. doi :10.1289/ehp.0800279 . PMC 2702409 . PMID 19590686 .
Rosado JA, Sage SO (2001). "Activation of store-mediated calcium entry by secretion-like coupling between the inositol 1,4,5-trisphosphate receptor type II and human transient receptor potential (hTrp1) channels in human platelets" . Biochem. J . 356 (Pt 1): 191–8. doi :10.1042/0264-6021:3560191 . PMC 1221827 . PMID 11336651 .
van Es MA, Van Vught PW, Blauw HM, et al. (2007). "ITPR2 as a susceptibility gene in sporadic amyotrophic lateral sclerosis: a genome-wide association study". Lancet Neurology . 6 (10): 869–77. doi :10.1016/S1474-4422(07)70222-3 . PMID 17827064 . S2CID 12953367 .
Harzheim D, Movassagh M, Foo RS, et al. (2009). "Increased InsP3Rs in the junctional sarcoplasmic reticulum augment Ca2+ transients and arrhythmias associated with cardiac hypertrophy" . Proc. Natl. Acad. Sci. U.S.A . 106 (27): 11406–11. Bibcode :2009PNAS..10611406H . doi :10.1073/pnas.0905485106 . PMC 2708695 . PMID 19549843 .
Rosado JA, Sage SO (2000). "Coupling between inositol 1,4,5-trisphosphate receptors and human transient receptor potential channel 1 when intracellular Ca2+ stores are depleted" . Biochem. J . 350 Pt 3 (3): 631–5. doi :10.1042/0264-6021:3500631 . PMC 1221291 . PMID 10970773 .
Uhl GR, Liu QR, Drgon T, et al. (2008). "Molecular genetics of successful smoking cessation: convergent genome-wide association study results" . Arch. Gen. Psychiatry . 65 (6): 683–93. doi :10.1001/archpsyc.65.6.683 . PMC 2430596 . PMID 18519826 .
Chiò A, Schymick JC, Restagno G, et al. (2009). "A two-stage genome-wide association study of sporadic amyotrophic lateral sclerosis" . Hum. Mol. Genet . 18 (8): 1524–32. doi :10.1093/hmg/ddp059 . PMC 2664150 . PMID 19193627 .
Miyachi K, Iwai M, Asada K, et al. (2007). "Inositol 1,4,5-trisphosphate receptors are autoantibody target antigens in patients with Sjögren's syndrome and other systemic rheumatic diseases". Mod Rheumatol . 17 (2): 137–43. doi :10.1007/s10165-006-0555-6 . PMID 17437169 . S2CID 36516047 .
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes" . Genome Res . 16 (1): 55–65. doi :10.1101/gr.4039406 . PMC 1356129 . PMID 16344560 .
Mery L, Magnino F, Schmidt K, et al. (2001). "Alternative splice variants of hTrp4 differentially interact with the C-terminal portion of the inositol 1,4,5-trisphosphate receptors" . FEBS Lett . 487 (3): 377–83. Bibcode :2001FEBSL.487..377M . doi :10.1016/S0014-5793(00)02362-0 . PMID 11163362 . S2CID 44945442 .
Diaz F, Bourguignon LY (2000). "Selective down-regulation of IP(3)receptor subtypes by caspases and calpain during TNF alpha -induced apoptosis of human T-lymphoma cells". Cell Calcium . 27 (6): 315–28. doi :10.1054/ceca.2000.0126 . PMID 11013462 .
Mayne M, Holden CP, Nath A, Geiger JD (2000). "Release of calcium from inositol 1,4,5-trisphosphate receptor-regulated stores by HIV-1 Tat regulates TNF-alpha production in human macrophages" . J. Immunol . 164 (12): 6538–42. doi :10.4049/jimmunol.164.12.6538 . PMID 10843712 .
Tanimura A, Tojyo Y, Turner RJ (2000). "Evidence that type I, II, and III inositol 1,4,5-trisphosphate receptors can occur as integral plasma membrane proteins" . J. Biol. Chem . 275 (35): 27488–93. doi :10.1074/jbc.M004495200 . PMID 10874040 .
Jurkovicova D, Sedlakova B, Lacinova L, et al. (2008). "Hypoxia differently modulates gene expression of inositol 1,4,5-trisphosphate receptors in mouse kidney and HEK 293 cell line". Ann. N. Y. Acad. Sci . 1148 (1): 421–7. Bibcode :2008NYASA1148..421J . doi :10.1196/annals.1410.034 . PMID 19120137 . S2CID 19136722 .
Bruce JI, Shuttleworth TJ, Giovannucci DR, Yule DI (2002). "Phosphorylation of inositol 1,4,5-trisphosphate receptors in parotid acinar cells. A mechanism for the synergistic effects of cAMP on Ca2+ signaling" . J. Biol. Chem . 277 (2): 1340–8. doi :10.1074/jbc.M106609200 . PMID 11694504 .
Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions" . Genome Res . 14 (9): 1711–8. doi :10.1101/gr.2435604 . PMC 515316 . PMID 15342556 .
Tovey SC, Dedos SG, Taylor EJ, et al. (2008). "Selective coupling of type 6 adenylyl cyclase with type 2 IP3 receptors mediates direct sensitization of IP3 receptors by cAMP" . J. Cell Biol . 183 (2): 297–311. doi :10.1083/jcb.200803172 . PMC 2568025 . PMID 18936250 .
Johnson JM, Castle J, Garrett-Engele P, et al. (2003). "Genome-wide survey of human alternative pre-mRNA splicing with exon junction microarrays". Science . 302 (5653): 2141–4. Bibcode :2003Sci...302.2141J . doi :10.1126/science.1090100 . PMID 14684825 . S2CID 10007258 .
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