Palacio (palace) is a Spanish habitational name. It may have originated from many places in Spain, especially in Galicia and Asturias.[1] Notable people with the surname include:
- Agustina Palacio de Libarona (1825–1880), Argentine writer, storyteller, heroine
- Alberto Palacio, engineer
- Alfredo Palacio, former president of Ecuador
- Andy Palacio, Belizean musician
- Emilio Palacio, Ecuadorian journalist
- Ernesto Palacio, opera singer
- Héctor Palacio, Colombian road racing cyclist
- Milt Palacio, basketball player
- Rodrigo Palacio, footballer
- R. J. Palacio, American writer of the 2012 children's novel Wonder