Protein-coding gene in the species Homo sapiens
Sclerostin domain-containing protein 1 is a protein that in humans is encoded by the SOSTDC1 gene .[ 5]
Function
This gene is a member of the sclerostin family and encodes Uterine sensitization-associated gene-1 (USAG-1), an N-glycosylated , secreted protein with a C-terminal , cystine , knot-like domain. This protein functions as a bone morphogenetic protein (BMP) antagonist. Specifically, it directly associates with BMPs, prohibiting them from binding their receptors, thereby regulating BMP signaling during cellular proliferation , differentiation , and programmed cell death .[ 5]
Inhibition of USAG-1 is of interest as a potential means of stimulating tooth regeneration for dentistry.[ 6] [ 7] [ 8]
References
^ a b c GRCh38: Ensembl release 89: ENSG00000171243 – Ensembl , May 2017
^ a b c GRCm38: Ensembl release 89: ENSMUSG00000036169 – Ensembl , May 2017
^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ a b "Entrez Gene: SOSTDC1 sclerostin domain containing 1" .
^ Murashima-Suginami A, Kiso H, Tokita Y, Mihara E, Nambu Y, Uozumi R, Tabata Y, Bessho K, Takagi J, Sugai M, Takahashi K (February 2021). "Anti-USAG-1 therapy for tooth regeneration through enhanced BMP signaling" . Science Advances . 7 (7). doi :10.1126/sciadv.abf1798 . PMC 7880588 . PMID 33579703 .
^ Ravi V, Murashima-Suginami A, Kiso H, Tokita Y, Huang CL, Bessho K, Takagi J, Sugai M, Tabata Y, Takahashi K (March 2023). "Advances in tooth agenesis and tooth regeneration" . Regenerative Therapy . 22 : 160–168. doi :10.1016/j.reth.2023.01.004 . PMC 9931762 . PMID 36819612 .
^ "World's 1st 'tooth regrowth' medicine moves toward clinical trials in Japan" . Mainichi . 12 June 2023.
Further reading
Yanagita M (June 2005). "BMP antagonists: their roles in development and involvement in pathophysiology". Cytokine & Growth Factor Reviews . 16 (3): 309–17. doi :10.1016/j.cytogfr.2005.02.007 . PMID 15951218 .
Laurikkala J, Kassai Y, Pakkasjärvi L, Thesleff I, Itoh N (December 2003). "Identification of a secreted BMP antagonist, ectodin, integrating BMP, FGF, and SHH signals from the tooth enamel knot" . Developmental Biology . 264 (1): 91–105. doi :10.1016/j.ydbio.2003.08.011 . PMID 14623234 .
Yanagita M, Oka M, Watabe T, Iguchi H, Niida A, Takahashi S, Akiyama T, Miyazono K, Yanagisawa M, Sakurai T (April 2004). "USAG-1: a bone morphogenetic protein antagonist abundantly expressed in the kidney". Biochemical and Biophysical Research Communications . 316 (2): 490–500. doi :10.1016/j.bbrc.2004.02.075 . PMID 15020244 .
Goto M, Eddy EM (October 2004). "Speriolin is a novel spermatogenic cell-specific centrosomal protein associated with the seventh WD motif of Cdc20" . The Journal of Biological Chemistry . 279 (40): 42128–38. doi :10.1074/jbc.M403190200 . PMID 15280373 .