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ECHA InfoCard | 100.000.929 |
Chemical and physical data | |
Formula | C8H12N2O2S |
Molar mass | 200.26 g·mol−1 |
3D model (JSmol) | |
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Thiobarbital is a drug which is a barbiturate derivative. It is the thiobarbiturate analogue of barbital.
Synthesis
![](http://upload.wikimedia.org/wikipedia/commons/thumb/a/a4/Thiobarbital_synthesis.svg/500px-Thiobarbital_synthesis.svg.png)
It is of note that although the drug can be prepared by the above route (cf e.g. thialbarbital), reaction of barbital with phosphorus pentasulfide constitutes an alternative route to thiobarbital.
References
- ^ Fischer E, Dilthey A (1904). "Ueber C-Dialkylbarbitursäuren und über die Ureïde der Dialkylessigsäuren". Justus Liebig's Annalen der Chemie. 335 (3): 334–368. doi:10.1002/jlac.19043350303.
- ^ Carrington HC (1944). "45. The action of phosphorus pentasulphide on barbituric acids". Journal of the Chemical Society (Resumed): 124. doi:10.1039/JR9440000124.