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Clinical data | |
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Routes of administration | Oral |
ATC code | |
Pharmacokinetic data | |
Protein binding | plasma protein |
Metabolism | unknown |
Elimination half-life | 1.5 hours |
Identifiers | |
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CAS Number | |
PubChem CID | |
DrugBank | |
CompTox Dashboard (EPA) | |
ECHA InfoCard | 100.051.397 |
Chemical and physical data | |
Formula | C16H17N3O5S |
Molar mass | 363.389 g/mol g·mol−1 |
3D model (JSmol) | |
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Cefadroxil is a broad-spectrum antibiotic effective in Gram-positive and Gram-negative bacterial infections. It is a bactericidal antibiotic. It is marked by pharco B international under the name of Curisafe.
Brand name:
1. Arocef (Eskayef Bangladesh Limited), Bangladesh 2. Zadro 500 , India
General use
Cefadroxil is a first-generation cephalosporin antibacterial drug that is the para-hydroxy derivative of cefalexin, and is used similarly in the treatment of mild to moderate susceptible infections such as the bacteria "Streptococcus pyogenes", otherwise known as strep throat.
Pharmacokinetics
Cefadroxil is almost completely absorbed from the gastrointestinal tract. After doses of 500 mg and 1 g by mouth, peak plasma concentrations of about 16 and 30 micrograms/mL respectively are obtained after 1.5 to 2 hours. Although peak concentrations are similar to those of cefalexin, plasma concentrations are more sustained. Dosage with food does not appear to affect the absorption of cefadroxil. About 20% of cefadroxil is reported to be bound to plasma proteins. The plasma half-life of cefadroxil is about 1.5 hours and is prolonged in patients with renal impairment.
Cefadroxil is widely distributed to body tissues and fluids. It crosses the placenta and appears in breast milk.
More than 90% of a dose of cefadroxil may be excreted unchanged in the urine within 24 hours by glomerular filtration and tubular secretion; peak urinary concentrations of 1.8 mg/mL have been reported after a dose of 500 mg. Cefadroxil is removed by haemodialysis.
Dosage
Cefadroxil is given by mouth, and doses are expressed in terms of the anhydrous substance; 1.04 g of cefadroxil monohydrate is equivalent to about 1 g of anhydrous cefadroxil.
Side effects
The most common side effects of Cefadroxil are diarrhea (which, less commonly, may be bloody), nausea, upset stomach, and vomiting. Other side effects include[1]:
- Rashes
- Hives
- Itching
- Red, swollen, or blistered skin
- Unusual bruising or bleeding
- Sore throat
- Difficulty breathing
- Tightness in the chest
- Swelling of the mouth, face, lips, or tongue
- Decreased urination
- Dark urine
- Vaginal itching, fish smelling odor, or discharge
- Fever
- Chills
- Joint pain
- Seizures
- Cramps
- Unusual tiredness or weakness
- Yellowing of the skin or eyes
Dental use
Cefadroxil is used as an antibiotic prophylaxis before dental procedures.
(Always consider Amoxicillin plus Metronidazole as first line of treatment for dental procedures. In Case of penicillin allergy consider "Cefadroxil" for prophylaxis.)
Veterinary use
Can be used for treating infected wounds on animals. Usually in powder form mixed with water has a color and smell similar to Tang. Given orally to animals, amount dependent on their weight and severity of infection.
References
- ^ "Cefadroxil side effects". Drugs.