![]() | |
![]() | |
Clinical data | |
---|---|
ATC code | |
Pharmacokinetic data | |
Elimination half-life | Distribution half life 12 minutes, elimination half 100 minutes |
Identifiers | |
| |
CAS Number | |
PubChem CID | |
DrugBank | |
ChemSpider | |
UNII | |
KEGG | |
CompTox Dashboard (EPA) | |
Chemical and physical data | |
Formula | C28H54GdN5O20 |
Molar mass | 938.01 g·mol−1 |
3D model (JSmol) | |
| |
| |
(verify) |
Gadopentetic acid (in the form of gadopentetate dimeglumine or Gd-DTPA) is the first paramagnetic magnetic resonance imaging (MRI) contrast agent. First described in 1981, and introduced in 1988, it is used to assist imaging of blood vessels and of inflamed or diseased tissue where the blood vessels become 'leaky'. It is often used when viewing intracranial lesions with abnormal vascularity or abnormalities in the blood-brain barrier. It is usually injected intravenously. Gd-DTPA is a gadolinium complex of diethylenetriamine pentaacetic acid and is classed as an acyclic, ionic gadolinium contrast medium. Its paramagnetic property reduces the T1 relaxation time (and to some extent the T2 and T2* relaxation times) in NMR, which is the source of its clinical utility.
Marketed as Magnevist by Bayer Schering Pharma, it was the first intravenous contrast agent to become available for clinical use, and is in widespread use around the world. Similar contrast agents are Dotarem (gadoterate) manufactured by Guerbet, MultiHance (gadobenate dimeglumine) and ProHance (gadoteridol) manufactured by Bracco, Omniscan (gadodiamide) manufactured by GE Healthcare, and OptiMARK (gadoversetamide) manufactured by Mallinckrodt.
Gadolinium based agents may cause a toxic reaction known as nephrogenic systemic fibrosis (NSF) in patients with severe kidney problems.[1][2]
References
- ^ Murphy KJ, Brunberg JA, Cohan RH (1996). "Adverse reactions to gadolinium contrast media: a review of 36 cases". American Journal of Roentgenology. 167 (4): 847–849. PMID 8819369.
{{cite journal}}
: CS1 maint: multiple names: authors list (link) - ^ H.S. Thomsen, S.K. Morcos and P. Dawson (2006). "Is there a causal relation between the administration of gadolinium-based contrast media and the development of nephrogenic systemic fibrosis (NSF)?". Clinical Radiology. 61 (11): 905–906. doi:10.1016/j.crad.2006.09.003. PMID 17018301.
{{cite journal}}
: Unknown parameter|month=
ignored (help)
External links
- Bayer Healthcare Pharmaceuticals page on Magnevist (for US)
- Bayer Schering Pharma global Magnevist Website
- "Gadopentetate Dimeglumine". Magnetic Resonance—Technology Information Portal. Retrieved 2006-03-27.