phenylbutyrate chemical structure | |
4-Phenylbutyric acid, sodium salt | |
CAS number |
ATC code AX16 |
Chemical formula | C10H11O2Na |
Molecular weight | 186.2 |
Bioavailability | ? |
Metabolism | to phenylacetate |
Elimination half-life | ? |
Excretion | 80% as phenylacetylglutamine |
Pregnancy category | not to be used |
Legal status | FDA approval 1994 |
Routes of administration | oral |
Sodium phenylbutyrate is an orphan drug, marketed by Ucyclyd Pharma (Hunt Valley, USA) under the trade name Buphenyl®. Phenylbutyrate is a prodrug. In the human body it is metabolized by beta-oxidation to phenylacetate. Phenylacetate conjugate with glutamine to phenylacetylglutamine, that is eliminated with the urine.