^ abThe Panthers traded second- and fourth-round selections (38th and 111th overall), and a 2021 sixth-round selection to the New York Jets in exchange for QB Sam Darnold.
^ abThe Panthers traded a fourth-round selection (137th overall) and a 2023 third-round selection to the New England Patriots in exchange for a third-round selection (94th overall).
^ abcdThe Panthers traded two fifth-round selections (144th and 149th overall) to the Washington Commanders in exchange for fourth- and sixth-round selections (120th and 189th overall).
^The Panthers traded a 2021 third-round selection to the Houston Texans in exchange for a fourth-round selection (137th overall), and 2021 fourth- and fifth-round selections.
^The Panthers traded a sixth-round selection (185th overall) to the Buffalo Bills in exchange for DE Darryl Johnson.
^ abThe Panthers traded LB Denzel Perryman and a seventh-round selection (227th overall) to the Las Vegas Raiders in exchange for a sixth-round selection (199th overall).
^The Panthers traded OT Greg Little to the Miami Dolpins in exchange for a seventh-round selection (242nd overall).
CAR – Robbie Anderson – 5 receptions, 102 yards, TD
In the Panthers' home opener against the Cleveland Browns, they came close to winning, but the Browns were able to hold them off. Cleveland defeated Carolina 26–24, meaning the Panthers started off the season 0–1.
Week 2: at New York Giants
Week 2: Carolina Panthers at New York Giants – Game summary
This was head coach Matt Rhule's first return to MetLife Stadium in 10 years, as he had previously served as the Giants' asst. offensive line coach under then-head coach Tom Coughlin in 2012, a season after the Giants won their 4th Super Bowl title. Things started poorly for the Panthers when, during kick-off, Chuba Hubbard fumbled the ball, and it was recovered by the New York Giants. New York ended up scoring a field goal on the ensuing drive. When Carolina got the ball back, they would fumble again and the Giants scored another field goal. In the second quarter, Eddy Piñeiro scores two field goals for the Panthers, tying the game. Baker Mayfield makes a complete pass to D. J. Moore in the third for a touchdown. The Giants answered back with a Daniel Bellinger touch down, tying the game at 13-13 going into the 4th quarter. The Panthers only scored three points in the fourth, while New York scored 6, giving the Giants a 19-16 win, dropping the Panthers to an 0–2 record.
Week 3: vs. New Orleans Saints
Week 3: New Orleans Saints at Carolina Panthers – Game summary
Period
1
2
3
4
Total
Saints
0
0
0
14
14
Panthers
7
6
0
9
22
at Bank of America Stadium, Charlotte, North Carolina
CAR – Laviska Shenault – 2 receptions, 90 yards, TD
The game started off well for Carolina in the first quarter when New Orleans fumbled the ball. Marquis Haynes recovered it and scored a fumble recovery touchdown for the Panthers. Carolina led by thirteen points at the half after Eddy Piñeiro kicked two field goals in the second quarter. Early in the fourth, Mark Ingram scores a touchdown for the Saints, giving them their first points of the game. Baker Mayfield completes a 67-yard pass to Laviska Shenault for a touchdown. They tried for a two-point conversion, but it failed. With 8:19 to go into the game, Piñeiro kicked another field goal for Carolina. With 2:22 remaining, Marquez Callaway scores a touchdown for the Saints, though it wasn't enough. Carolina defeated New Orleans 22–14, snapping a 9 game losing streak and improving to 1–2.
Week 4: vs. Arizona Cardinals
Week 4: Arizona Cardinals at Carolina Panthers – Game summary
Period
1
2
3
4
Total
Cardinals
0
3
7
16
26
Panthers
0
10
0
6
16
at Bank of America Stadium, Charlotte, North Carolina
The Panthers lose to San Francisco 15–37 and dropped to 1–4 on the year. This was head coach Matt Rhule's and defensive coordinatorPhil Snow's last game with the Panthers, as both were fired in the days following the loss with Steve Wilks promoted to interim head coach. In addition, Baker Mayfield, who had another disappointing performance, was benched in favor of P. J. Walker.
Week 6: at Los Angeles Rams
Week 6: Carolina Panthers at Los Angeles Rams – Game summary
Carolina started the game off with a field goal in the first. Both the Panthers and the Rams scored touchdowns in the second, leaving them up 10-7 into the half. The Panthers went scoreless in the second half, while Los Angeles took control and scored 17. The Rams defeated Carolina 24–10. For the first time since 2016, the Panthers were 1–5.
This was also the last game Christian McCaffrey would play in as a player of the Panthers, as he was traded to the San Francisco 49ers on October 20, 2022.[7]
Week 7: vs. Tampa Bay Buccaneers
Week 7: Tampa Bay Buccaneers at Carolina Panthers – Game summary
Period
1
2
3
4
Total
Buccaneers
0
0
0
3
3
Panthers
0
7
7
7
21
at Bank of America Stadium, Charlotte, North Carolina
Carolina and Tampa Bay were both scoreless in the first quarter. With 35 seconds to go in the second, P. J. Walker made a 20-yard pass to D. J. Moore for a Panthers touchdown, putting Carolina up by 7 at the half. Chuba Hubbard scored a touchdown in the third, as Ryan Succop made a field goal for the Bucs in the fourth. Walker threw it to Tommy Tremble for a game sealing touchdown. The Panthers won 21–3 and improved to 2–5.
Week 8: at Atlanta Falcons
Week 8: Carolina Panthers at Atlanta Falcons – Game summary
In the first half of this blowout, Carolina was scoreless, in part due to poor play from Walker, who posted a 0.0 passer rating, while the Cincinnati Bengals scored 5 touchdowns, four of them from Bengals running back Joe Mixon. Walker was removed from the game in favor of Mayfield, as both teams scored 7 in the third quarter. The Panthers went on to score 14 in the fourth, and even though Cincinnati went scoreless, the Bengals kept their comfortable lead and won 42–21. Carolina fell to 2–7.
Week 10: vs. Atlanta Falcons
Week 10: Atlanta Falcons at Carolina Panthers – Game summary
Period
1
2
3
4
Total
Falcons
0
3
6
6
15
Panthers
3
10
6
6
25
at Bank of America Stadium, Charlotte, North Carolina
Carolina sought revenge against Atlanta in this Thursday Night Football game after losing in a heartbreaker 11 days prior. The Panthers got their chance, winning 25–15 and improving to 3–7.
Week 11: at Baltimore Ravens
Week 11: Carolina Panthers at Baltimore Ravens – Game summary
Baker returned from the bench in a 13–3 low scoring affair that saw Carolina fall to 3–8. This was also the last game he'd play for the Panthers, as Sam Darnold was healthy enough to return, and Mayfield would soon be released by the Panthers, signing with the Rams.
Week 12: vs. Denver Broncos
Week 12: Denver Broncos at Carolina Panthers – Game summary
Period
1
2
3
4
Total
Broncos
0
3
0
7
10
Panthers
7
3
7
6
23
at Bank of America Stadium, Charlotte, North Carolina
Darnold's first start in the season saw the Panthers beat the Broncos for the first time since the 2008 season in a 23-10 score. The Panthers improved to 4-8.
Week 14: at Seattle Seahawks
Week 14: Carolina Panthers at Seattle Seahawks – Game summary
Carolina defeated Seattle for the first time since 2015, winning 30–24. The Panthers improved to 5–8, and with a Buccaneers loss, also allowed them control of their own destiny, meaning they were guaranteed a spot in the playoffs if they could win out.
Week 15: vs. Pittsburgh Steelers
Week 15: Pittsburgh Steelers at Carolina Panthers – Game summary
Period
1
2
3
4
Total
Steelers
7
7
7
3
24
Panthers
0
7
0
9
16
at Bank of America Stadium, Charlotte, North Carolina
Mitchell Trubisky and the Pittsburgh Steelers were too much for Carolina, defeating them 24–16. The Panthers fell to 5–9, yet still maintained control of their destiny.
Week 16: vs. Detroit Lions
Week 16: Detroit Lions at Carolina Panthers – Game summary
Period
1
2
3
4
Total
Lions
7
0
6
10
23
Panthers
7
17
7
6
37
at Bank of America Stadium, Charlotte, North Carolina
Date: December 24
Game time: 1:00 p.m. EST
Game weather: Sunny, 20 °F (−7 °C)
Game attendance: 69,173
Referee: Shawn Hochuli
TV announcers (Fox): Chris Myers, Robert Smith and Jen Hale
On Christmas Eve, the Panthers ran all over the Detroit Lions, beating them 37–23, as well as setting new franchise records in rushing yards in a game and total yards in a game. Carolina improved to 6–9, improving on their 5 win totals from the previous three seasons.
Week 17: at Tampa Bay Buccaneers
Week 17: Carolina Panthers at Tampa Bay Buccaneers – Game summary
In a must win game, the Panthers visited the Buccaneers, and held a 14-0 lead at one point, but the Buccaneers were able to recover and win 30–24. Carolina fell to 6–10 and were officially eliminated from playoff contention.
Week 18: at New Orleans Saints
Week 18: Carolina Panthers at New Orleans Saints – Game summary
The Panthers are able to hold the Saints to a touchdown and win 10–7. They finished the season 7–10, capping off the first season since 2018 the Panthers won more than 5 games.
^ abSan Francisco finished ahead of Minnesota based on conference record (10–2 vs. 8–4).
^ abSeattle finished ahead of Detroit based on head-to-head victory.
^ abcCarolina finished ahead of New Orleans and Atlanta based on head-to-head record (3–1 vs. 2–2/1–3).
^ abNew Orleans finished ahead of Atlanta based on head-to-head sweep.
^When breaking ties for three or more teams under the NFL's rules, they are first broken within divisions, then comparing only the highest-ranked remaining team from each division.