Protein-coding gene in the species Homo sapiens
AP2A2 Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1B9K , 1KY6 , 1KY7 , 1KYD , 1KYF , 1KYU , 1QTP , 1QTS , 1W80 , 2JKR , 2JKT , 2VJ0 , 3HS8
Identifiers Aliases AP2A2 , ADTAB, CLAPA2, HIP-9, HIP9, HYPJ, adaptor related protein complex 2 alpha 2 subunit, adaptor related protein complex 2 subunit alpha 2External IDs OMIM : 607242 ; MGI : 101920 ; HomoloGene : 5335 ; GeneCards : AP2A2 ; OMA :AP2A2 - orthologs Wikidata
AP-2 complex subunit alpha-2 is a protein that in humans is encoded by the AP2A2 gene .[ 5] [ 6] [ 7]
Interactions
AP2A2 has been shown to interact with EPN1 [ 8] and SHC1 .[ 9]
References
^ a b c ENSG00000280759, ENSG00000183020 GRCh38: Ensembl release 89: ENSG00000281385, ENSG00000280759, ENSG00000183020 – Ensembl , May 2017
^ a b c GRCm38: Ensembl release 89: ENSMUSG00000002957 – Ensembl , May 2017
^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Faber PW, Barnes GT, Srinidhi J, Chen J, Gusella JF, MacDonald ME (Sep 1998). "Huntingtin interacts with a family of WW domain proteins" . Human Molecular Genetics . 7 (9): 1463–74. doi :10.1093/hmg/7.9.1463 . PMID 9700202 .
^ Robinson MS (Mar 1989). "Cloning of cDNAs encoding two related 100-kD coated vesicle proteins (alpha-adaptins)" . The Journal of Cell Biology . 108 (3): 833–42. doi :10.1083/jcb.108.3.833 . PMC 2115374 . PMID 2564002 .
^ "Entrez Gene: AP2A2 adaptor-related protein complex 2, alpha 2 subunit" .
^ Chen H, Fre S, Slepnev VI, Capua MR, Takei K, Butler MH, Di Fiore PP, De Camilli P (Aug 1998). "Epsin is an EH-domain-binding protein implicated in clathrin-mediated endocytosis". Nature . 394 (6695): 793–7. Bibcode :1998Natur.394..793C . doi :10.1038/29555 . PMID 9723620 . S2CID 4430975 .
^ Okabayashi Y, Sugimoto Y, Totty NF, Hsuan J, Kido Y, Sakaguchi K, Gout I, Waterfield MD, Kasuga M (Mar 1996). "Interaction of Shc with adaptor protein adaptins" . The Journal of Biological Chemistry . 271 (9): 5265–9. doi :10.1074/jbc.271.9.5265 . PMID 8617812 .
Further reading
Kirchhausen T (2000). "Clathrin". Annual Review of Biochemistry . 69 : 699–727. doi :10.1146/annurev.biochem.69.1.699 . PMID 10966473 .
Nakajima D, Okazaki N, Yamakawa H, Kikuno R, Ohara O, Nagase T (Jun 2002). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Research . 9 (3): 99–106. CiteSeerX 10.1.1.500.923 . doi :10.1093/dnares/9.3.99 . PMID 12168954 .
Maruyama K, Sugano S (Jan 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene . 138 (1–2): 171–4. doi :10.1016/0378-1119(94)90802-8 . PMID 8125298 .
David C, McPherson PS, Mundigl O, de Camilli P (Jan 1996). "A role of amphiphysin in synaptic vesicle endocytosis suggested by its binding to dynamin in nerve terminals" . Proceedings of the National Academy of Sciences of the United States of America . 93 (1): 331–5. Bibcode :1996PNAS...93..331D . doi :10.1073/pnas.93.1.331 . PMC 40232 . PMID 8552632 .
Okabayashi Y, Sugimoto Y, Totty NF, Hsuan J, Kido Y, Sakaguchi K, Gout I, Waterfield MD, Kasuga M (Mar 1996). "Interaction of Shc with adaptor protein adaptins" . The Journal of Biological Chemistry . 271 (9): 5265–9. doi :10.1074/jbc.271.9.5265 . PMID 8617812 .
Benmerah A, Bégue B, Dautry-Varsat A, Cerf-Bensussan N (May 1996). "The ear of alpha-adaptin interacts with the COOH-terminal domain of the Eps 15 protein" . The Journal of Biological Chemistry . 271 (20): 12111–6. doi :10.1074/jbc.271.20.12111 . PMID 8662627 .
van Delft S, Schumacher C, Hage W, Verkleij AJ, van Bergen en Henegouwen PM (Feb 1997). "Association and colocalization of Eps15 with adaptor protein-2 and clathrin" . The Journal of Cell Biology . 136 (4): 811–21. doi :10.1083/jcb.136.4.811 . PMC 2132490 . PMID 9049247 .
Ramjaun AR, Micheva KD, Bouchelet I, McPherson PS (Jun 1997). "Identification and characterization of a nerve terminal-enriched amphiphysin isoform" . The Journal of Biological Chemistry . 272 (26): 16700–6. doi :10.1074/jbc.272.26.16700 . PMID 9195986 .
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (Oct 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene . 200 (1–2): 149–56. doi :10.1016/S0378-1119(97)00411-3 . PMID 9373149 .
Chen H, Fre S, Slepnev VI, Capua MR, Takei K, Butler MH, Di Fiore PP, De Camilli P (Aug 1998). "Epsin is an EH-domain-binding protein implicated in clathrin-mediated endocytosis". Nature . 394 (6695): 793–7. Bibcode :1998Natur.394..793C . doi :10.1038/29555 . PMID 9723620 . S2CID 4430975 .
Berlioz-Torrent C, Shacklett BL, Erdtmann L, Delamarre L, Bouchaert I, Sonigo P, Dokhelar MC, Benarous R (Feb 1999). "Interactions of the cytoplasmic domains of human and simian retroviral transmembrane proteins with components of the clathrin adaptor complexes modulate intracellular and cell surface expression of envelope glycoproteins" . Journal of Virology . 73 (2): 1350–61. doi :10.1128/JVI.73.2.1350-1361.1999 . PMC 103959 . PMID 9882340 .
Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Dec 1998). "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro" . DNA Research . 5 (6): 355–64. doi :10.1093/dnares/5.6.355 . PMID 10048485 .
Traub LM, Downs MA, Westrich JL, Fremont DH (Aug 1999). "Crystal structure of the alpha appendage of AP-2 reveals a recruitment platform for clathrin-coat assembly" . Proceedings of the National Academy of Sciences of the United States of America . 96 (16): 8907–12. Bibcode :1999PNAS...96.8907T . doi :10.1073/pnas.96.16.8907 . PMC 17706 . PMID 10430869 .
Page LJ, Sowerby PJ, Lui WW, Robinson MS (Sep 1999). "Gamma-synergin: an EH domain-containing protein that interacts with gamma-adaptin" . The Journal of Cell Biology . 146 (5): 993–1004. doi :10.1083/jcb.146.5.993 . PMC 2169493 . PMID 10477754 .
Kim ST, Lim DS, Canman CE, Kastan MB (Dec 1999). "Substrate specificities and identification of putative substrates of ATM kinase family members" . The Journal of Biological Chemistry . 274 (53): 37538–43. doi :10.1074/jbc.274.53.37538 . PMID 10608806 .
Slepnev VI, Ochoa GC, Butler MH, De Camilli P (Jun 2000). "Tandem arrangement of the clathrin and AP-2 binding domains in amphiphysin 1 and disruption of clathrin coat function by amphiphysin fragments comprising these sites" . The Journal of Biological Chemistry . 275 (23): 17583–9. doi :10.1074/jbc.M910430199 . PMID 10748223 .
Jullien-Flores V, Mahé Y, Mirey G, Leprince C, Meunier-Bisceuil B, Sorkin A, Camonis JH (Aug 2000). "RLIP76, an effector of the GTPase Ral, interacts with the AP2 complex: involvement of the Ral pathway in receptor endocytosis" (PDF) . Journal of Cell Science . 113 (16): 2837–44. doi :10.1242/jcs.113.16.2837 . PMID 10910768 .
External links
PDB gallery
1b9k : ALPHA-ADAPTIN APPENDAGE DOMAIN, FROM CLATHRIN ADAPTOR AP2
1gw5 :
1ky6 : AP-2 CLATHRIN ADAPTOR ALPHA-APPENDAGE IN COMPLEX WITH EPSIN DPW PEPTIDE
1ky7 : THE AP-2 CLATHRIN ADAPTOR ALPHA-APPENDAGE IN COMPLEX WITH AMPHIPHYSIN FXDXF
1kyd : AP-2 CLATHRIN ADAPTOR ALPHA-APPENDAGE IN COMPLEX WITH EPSIN DPW PEPTIDE
1kyf : AP-2 CLATHRIN ADAPTOR ALPHA-APPENDAGE IN COMPLEX WITH EPS15 DPF PEPTIDE
1kyu : AP-2 CLATHRIN ADAPTOR ALPHA-APPENDAGE IN COMPLEX WITH EPS15 DPF PEPTIDE
1qtp : CRYSTAL STRUCTURE OF THE AP-2 CLATHRIN ADAPTOR ALPHA-APPENDAGE
1qts : CRYSTAL STRUCTURE OF THE AP-2 CLATHRIN ADAPTOR ALPHA-APPENDAGE
1w80 : CRYSTAL STRUCTURE OF THE ALPHA-ADAPTIN APPENDAGE DOMAIN, FROM THE AP2 ADAPTOR COMPLEX, BOUND TO 2 PEPTIDES FROM SYNAPTOJANIN170