Class II PI 3-kinases are a subgroup of the enzyme family, phosphoinositide 3-kinase that share a common protein domain structure, substrate specificity and method of activation.
Class II PI 3-kinases were the most recently identified class of PI 3-kinases.
There are three class II PI 3-kinase isoforms expressed in mammalian cells;
- PI3K-C2α encoded by the PIK3C2A gene
- PI3K-C2β encoded by the PIK3C2B gene
- PI3K-C2γ encoded by the PIK3C2G gene
See also
References
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- Foster FM, Traer CJ, Abraham SM, Fry MJ (August 2003). "The phosphoinositide (PI) 3-kinase family". Journal of Cell Science. 116 (Pt 15): 3037–3040. doi:10.1242/jcs.00609. PMID 12829733.
- Vanhaesebroeck B, Waterfield MD (November 1999). "Signaling by distinct classes of phosphoinositide 3-kinases". Experimental Cell Research. 253 (1): 239–254. doi:10.1006/excr.1999.4701. PMID 10579926.