Portalegre may refer to:
Brazil
- Portalegre, Rio Grande do Norte, a municipality in the state of Rio Grande do Norte in the Northeast region of Brazil.
Portugal
- Portalegre District, a district in Portugal
- Portalegre, Portugal, a municipality in the district of Portalegre
- Castle of Portalegre, a medieval castle in the civil parish of Sé e São Lourenço, municipality of Portalegre
- Portalegre, Portugal, a municipality in the district of Portalegre
- Portalegre Football Association, a district governing body for the all football competitions in the Portuguese district of Portalegre.
- Portalegre wine, a Portuguese wine region centered on the Portalegre.
- Count of Portalegre, was a Portuguese title of nobility.