SB or Sb may refer to:
- Spina bifida
- S.B., Scientiæ Baccalaureus or Bachelor of Science, an academic degree
- Senate Bill, especially when quoting a bill's code (e.g. "SB 1234")
- Sonderbehandlung, a German euphemism used during the Nazi era denoting murder
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Science
- Sb, antimony's chemical symbol
- sb, stilb (luminance), a unit of luminance
- SB, Barred spiral galaxy
- SB1 and SB2, designations for spectroscopic binary stars
Sport and games
- Super Bowl, the National Football League championship game
- Stolen base, an event in baseball
- Nike SB, a line of skateboarding shoes by Nike
Police and military
- Special Branch, a division of UK and some Commonwealth countries' police services
- Służba Bezpieczeństwa, the former Polish secret police
- Special Warfare Boat Operator, a United States Navy occupational rating
Places
- Solomon Islands' ISO 3166 country code
- .sb, Internet country code top-level domain for Solomon Islands
- Saint Pierre and Miquelon's FIPS PUB 10-4 territory code
- San Bernardino, California
- Santa Barbara, California
- Stony Brook, New York
Transportation
- Tupolev SB, a Soviet bomber of World War II
- Aircalin's IATA code
- South Buffalo Railway's reporting code
See also
- SB buffer, a buffer for electrophoresis