Homeobox B9 | |||||||||||||
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Identifiers | |||||||||||||
Symbols | HOXB9 ; HOX-2.5; HOX2; HOX2E | ||||||||||||
External IDs | OMIM: 142964 MGI: 96190 HomoloGene: 7367 GeneCards: HOXB9 Gene | ||||||||||||
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RNA expression pattern | |||||||||||||
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More reference expression data | |||||||||||||
Orthologs | |||||||||||||
Species | Human | Mouse | |||||||||||
Entrez | 3219 | 15417 | |||||||||||
Ensembl | ENSG00000170689 | ENSMUSG00000020875 | |||||||||||
UniProt | P17482 | P20615 | |||||||||||
RefSeq (mRNA) | NM_024017 | NM_008270 | |||||||||||
RefSeq (protein) | NP_076922 | NP_032296 | |||||||||||
Location (UCSC) | Chr 17: 46.7 – 46.7 Mb |
Chr 11: 96.27 – 96.28 Mb |
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PubMed search | [1] | [2] | |||||||||||
Homeobox protein Hox-B9 is a protein that in humans is encoded by the HOXB9 gene.[1][2][3]
Function
This gene is a member of the Abd-B homeobox family and encodes a protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded nuclear protein functions as a sequence-specific transcription factor that is involved in cell proliferation and differentiation. Increased expression of this gene is associated with some cases of leukemia, prostate cancer and lung cancer.[3]
Interactions
HOXB9 has been shown to interact with BTG2[4] and BTG1.[4]
See also
References
- ^ McAlpine PJ, Shows TB (August 1990). "Nomenclature for human homeobox genes". Genomics 7 (3): 460. doi:10.1016/0888-7543(90)90186-X. PMID 1973146.
- ^ Scott MP (December 1992). "Vertebrate homeobox gene nomenclature". Cell 71 (4): 551–3. doi:10.1016/0092-8674(92)90588-4. PMID 1358459.
- ^ a b "Entrez Gene: HOXB9 homeobox B9".
- ^ a b Prévôt D, Voeltzel T, Birot AM, Morel AP, Rostan MC, Magaud JP et al. (January 2000). "The leukemia-associated protein Btg1 and the p53-regulated protein Btg2 interact with the homeoprotein Hoxb9 and enhance its transcriptional activation". J. Biol. Chem. 275 (1): 147–53. doi:10.1074/jbc.275.1.147. PMID 10617598.
Further reading
- Deguchi Y, Kehrl JH (1991). "Selective expression of two homeobox genes in CD34-positive cells from human bone marrow". Blood 78 (2): 323–8. PMID 1712647.
- Peverali FA, D'Esposito M, Acampora D, Bunone G, Negri M, Faiella A et al. (1990). "Expression of HOX homeogenes in human neuroblastoma cell culture lines". Differentiation 45 (1): 61–9. doi:10.1111/j.1432-0436.1990.tb00458.x. PMID 1981366.
- Giampaolo A, Acampora D, Zappavigna V, Pannese M, D'Esposito M, Carè A et al. (1989). "Differential expression of human HOX-2 genes along the anterior-posterior axis in embryonic central nervous system". Differentiation 40 (3): 191–7. doi:10.1111/j.1432-0436.1989.tb00598.x. PMID 2570724.
- Acampora D, D'Esposito M, Faiella A, Pannese M, Migliaccio E, Morelli F et al. (1989). "The human HOX gene family". Nucleic Acids Res. 17 (24): 10385–402. doi:10.1093/nar/17.24.10385. PMC 335308. PMID 2574852.
- Boncinelli E, Acampora D, Pannese M, D'Esposito M, Somma R, Gaudino G et al. (1989). "Organization of human class I homeobox genes". Genome 31 (2): 745–56. doi:10.1139/g89-133. PMID 2576652.
- Apiou F, Flagiello D, Cillo C, Malfoy B, Poupon MF, Dutrillaux B (1996). "Fine mapping of human HOX gene clusters". Cytogenet. Cell Genet. 73 (1-2): 114–5. doi:10.1159/000134320. PMID 8646877.
- Ohnishi K, Tobita T, Sinjo K, Takeshita A, Ohno R (1998). "Modulation of homeobox B6 and B9 genes expression in human leukemia cell lines during myelomonocytic differentiation". Leuk. Lymphoma 31 (5-6): 599–608. doi:10.3109/10428199809057620. PMID 9922051.
- Prévôt D, Voeltzel T, Birot AM, Morel AP, Rostan MC, Magaud JP et al. (2000). "The leukemia-associated protein Btg1 and the p53-regulated protein Btg2 interact with the homeoprotein Hoxb9 and enhance its transcriptional activation". J. Biol. Chem. 275 (1): 147–53. doi:10.1074/jbc.275.1.147. PMID 10617598.
- Calvo R, West J, Franklin W, Erickson P, Bemis L, Li E et al. (2000). "Altered HOX and WNT7A expression in human lung cancer". Proc. Natl. Acad. Sci. U.S.A. 97 (23): 12776–81. doi:10.1073/pnas.97.23.12776. PMC 18840. PMID 11070089.
- de Pinieux G, Legrier ME, Poirson-Bichat F, Courty Y, Bras-Gonçalves R, Dutrillaux AM et al. (2001). "Clinical and experimental progression of a new model of human prostate cancer and therapeutic approach". Am. J. Pathol. 159 (2): 753–64. doi:10.1016/S0002-9440(10)61746-4. PMC 1850557. PMID 11485933.
- Shen WF, Krishnan K, Lawrence HJ, Largman C (2001). "The HOX homeodomain proteins block CBP histone acetyltransferase activity". Mol. Cell. Biol. 21 (21): 7509–22. doi:10.1128/MCB.21.21.7509-7522.2001. PMC 99922. PMID 11585930.
- Kosaki K, Kosaki R, Suzuki T, Yoshihashi H, Takahashi T, Sasaki K et al. (2002). "Complete mutation analysis panel of the 39 human HOX genes". Teratology 65 (2): 50–62. doi:10.1002/tera.10009. PMID 11857506.
- Hori Y, Gu X, Xie X, Kim SK (2005). "Differentiation of insulin-producing cells from human neural progenitor cells". PLoS Med. 2 (4): e103. doi:10.1371/journal.pmed.0020103. PMC 1087208. PMID 15839736.
- Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
- Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
External links
- HOXB9 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
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This article incorporates text from the United States National Library of Medicine, which is in the public domain.