Homeobox protein Hox-A5 is a protein that in humans is encoded by the HOXA5gene.[1][2][3]
In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. Methylation of this gene may result in the loss of its expression and, since the encoded protein upregulates the tumor suppressor p53, this protein may play an important role in tumorigenesis.[3]
Boncinelli E, Acampora D, Pannese M et al. (1990). "Organization of human class I homeobox genes.". Genome31 (2): 745–56. doi:10.1139/g89-133. PMID2576652.CS1 maint: Explicit use of et al. (link)
Apiou F, Flagiello D, Cillo C et al. (1996). "Fine mapping of human HOX gene clusters.". Cytogenet. Cell Genet.73 (1–2): 114–5. doi:10.1159/000134320. PMID8646877.CS1 maint: Explicit use of et al. (link)
Stelnicki EJ, Kömüves LG, Kwong AO et al. (1998). "HOX homeobox genes exhibit spatial and temporal changes in expression during human skin development". J. Invest. Dermatol.110 (2): 110–5. doi:10.1046/j.1523-1747.1998.00092.x. PMID9457903.CS1 maint: Explicit use of et al. (link)
Crooks GM, Fuller J, Petersen D et al. (1999). "Constitutive HOXA5 expression inhibits erythropoiesis and increases myelopoiesis from human hematopoietic progenitors". Blood94 (2): 519–28. PMID10397719.CS1 maint: Explicit use of et al. (link)
Raman V, Tamori A, Vali M et al. (2000). "HOXA5 regulates expression of the progesterone receptor". J. Biol. Chem.275 (34): 26551–5. doi:10.1074/jbc.C000324200. PMID10875927.CS1 maint: Explicit use of et al. (link)
Raman V, Martensen SA, Reisman D et al. (2000). "Compromised HOXA5 function can limit p53 expression in human breast tumours". Nature405 (6789): 974–8. doi:10.1038/35016125. PMID10879542.CS1 maint: Explicit use of et al. (link)
Kosaki K, Kosaki R, Suzuki T et al. (2002). "Complete mutation analysis panel of the 39 human HOX genes". Teratology65 (2): 50–62. doi:10.1002/tera.10009. PMID11857506.CS1 maint: Explicit use of et al. (link)
Foucher I, Volovitch M, Frain M et al. (2002). "Hoxa5 overexpression correlates with IGFBP1 upregulation and postnatal dwarfism: evidence for an interaction between Hoxa5 and Forkhead box transcription factors". Development129 (17): 4065–74. PMID12163409.CS1 maint: Explicit use of et al. (link)
Foucher I, Montesinos ML, Volovitch M et al. (2003). "Joint regulation of the MAP1B promoter by HNF3beta/Foxa2 and Engrailed is the result of a highly conserved mechanism for direct interaction of homeoproteins and Fox transcription factors". Development130 (9): 1867–76. doi:10.1242/dev.00414. PMID12642491.CS1 maint: Explicit use of et al. (link)
Hillier LW, Fulton RS, Fulton LA et al. (2003). "The DNA sequence of human chromosome 7". Nature424 (6945): 157–64. doi:10.1038/nature01782. PMID12853948.CS1 maint: Explicit use of et al. (link)
1hom: DETERMINATION OF THE THREE-DIMENSIONAL STRUCTURE OF THE ANTENNAPEDIA HOMEODOMAIN FROM DROSOPHILA IN SOLUTION BY 1H NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY
1san: THE DES(1-6)ANTENNAPEDIA HOMEODOMAIN: COMPARISON OF THE NMR SOLUTION STRUCTURE AND THE DNA BINDING AFFINITY WITH THE INTACT ANTENNAPEDIA HOMEODOMAIN