In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2), expression of cell surface markers, and class switch of immunoglobulins.[3]
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Gupta S, Jiang M, Pernis AB (1999). "IFN-alpha activates Stat6 and leads to the formation of Stat2:Stat6 complexes in B cells". J. Immunol.163 (7): 3834–41. PMID10490982.
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