Testicular receptor 4 also known as NR2C2 (nuclear receptor subfamily 2, group C, member 2) is a protein that in humans is encoded by the NR2C2 gene.[1][2][3]
The testicular receptor 4 is a member of the nuclear receptor family of transcription factors.
Interactions
Testicular receptor 4 has been shown to interact with
See also
References
- ^ "Entrez Gene: NR2C2".
- ^ Chang C, Da Silva SL, Ideta R, Lee Y, Yeh S, Burbach JP (June 1994). "Human and rat TR4 orphan receptors specify a subclass of the steroid receptor superfamily". Proc. Natl. Acad. Sci. U.S.A. 91 (13): 6040–4. doi:10.1073/pnas.91.13.6040. PMC 44133. PMID 8016112.
- ^ Yoshikawa T, DuPont BR, Leach RJ, Detera-Wadleigh SD (July 1996). "New variants of the human and rat nuclear hormone receptor, TR4: expression and chromosomal localization of the human gene". Genomics 35 (2): 361–6. doi:10.1006/geno.1996.0368. PMID 8661150.
- ^ Lee YF, Shyr CR, Thin TH, Lin WJ, Chang C (December 1999). "Convergence of two repressors through heterodimer formation of androgen receptor and testicular orphan receptor-4: a unique signaling pathway in the steroid receptor superfamily". Proc. Natl. Acad. Sci. U.S.A. 96 (26): 14724–9. doi:10.1073/pnas.96.26.14724. PMC 24715. PMID 10611280.
- ^ Shyr CR, Hu YC, Kim E, Chang C (April 2002). "Modulation of estrogen receptor-mediated transactivation by orphan receptor TR4 in MCF-7 cells". J. Biol. Chem. 277 (17): 14622–8. doi:10.1074/jbc.M110051200. PMID 11844790.
- ^ Lin WJ, Li J, Lee YF, Yeh SD, Altuwaijri S, Ou JH, Chang C (March 2003). "Suppression of hepatitis B virus core promoter by the nuclear orphan receptor TR4". J. Biol. Chem. 278 (11): 9353–60. doi:10.1074/jbc.M205944200. PMID 12522137.
Further reading
- Hirose T, Fujimoto W, Tamaai T et al. (1995). "TAK1: molecular cloning and characterization of a new member of the nuclear receptor superfamily.". Mol. Endocrinol. 8 (12): 1667–80. doi:10.1210/me.8.12.1667. PMID 7708055.
- Young WJ, Smith SM, Chang C (1997). "Induction of the intronic enhancer of the human ciliary neurotrophic factor receptor (CNTFRalpha) gene by the TR4 orphan receptor. A member of steroid receptor superfamily.". J. Biol. Chem. 272 (5): 3109–16. doi:10.1074/jbc.272.5.3109. PMID 9006963.
- Lee CH, Chinpaisal C, Wei LN (1998). "A novel nuclear receptor heterodimerization pathway mediated by orphan receptors TR2 and TR4.". J. Biol. Chem. 273 (39): 25209–15. doi:10.1074/jbc.273.39.25209. PMID 9737983.
- Lee YF, Shyr CR, Thin TH et al. (2000). "Convergence of two repressors through heterodimer formation of androgen receptor and testicular orphan receptor-4: a unique signaling pathway in the steroid receptor superfamily.". Proc. Natl. Acad. Sci. U.S.A. 96 (26): 14724–9. doi:10.1073/pnas.96.26.14724. PMC 24715. PMID 10611280.
- Wang X, Yeh S, Wu G et al. (2001). "Identification and characterization of a novel androgen receptor coregulator ARA267-alpha in prostate cancer cells.". J. Biol. Chem. 276 (44): 40417–23. doi:10.1074/jbc.M104765200. PMID 11509567.
- Yeung KC, Rose DW, Dhillon AS et al. (2001). "Raf kinase inhibitor protein interacts with NF-kappaB-inducing kinase and TAK1 and inhibits NF-kappaB activation.". Mol. Cell. Biol. 21 (21): 7207–17. doi:10.1128/MCB.21.21.7207-7217.2001. PMC 99896. PMID 11585904.
- Shyr CR, Hu YC, Kim E, Chang C (2002). "Modulation of estrogen receptor-mediated transactivation by orphan receptor TR4 in MCF-7 cells.". J. Biol. Chem. 277 (17): 14622–8. doi:10.1074/jbc.M110051200. PMID 11844790.
- Tanabe O, Katsuoka F, Campbell AD et al. (2002). "An embryonic/fetal beta-type globin gene repressor contains a nuclear receptor TR2/TR4 heterodimer.". EMBO J. 21 (13): 3434–42. doi:10.1093/emboj/cdf340. PMC 126089. PMID 12093744.
- Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Yang Y, Wang X, Dong T et al. (2003). "Identification of a novel testicular orphan receptor-4 (TR4)-associated protein as repressor for the selective suppression of TR4-mediated transactivation.". J. Biol. Chem. 278 (9): 7709–17. doi:10.1074/jbc.M207116200. PMID 12486131.
- Lin WJ, Li J, Lee YF et al. (2003). "Suppression of hepatitis B virus core promoter by the nuclear orphan receptor TR4.". J. Biol. Chem. 278 (11): 9353–60. doi:10.1074/jbc.M205944200. PMID 12522137.
- Takaesu G, Surabhi RM, Park KJ et al. (2003). "TAK1 is critical for IkappaB kinase-mediated activation of the NF-kappaB pathway.". J. Mol. Biol. 326 (1): 105–15. doi:10.1016/S0022-2836(02)01404-3. PMID 12547194.
- Inui S, Lee YF, Chang E et al. (2003). "Differential and bi-directional regulation between TR2/TR4 orphan nuclear receptors and a specific ligand mediated-peroxisome proliferator-activated receptor alpha in human HaCaT keratinocytes.". J. Dermatol. Sci. 31 (1): 65–71. doi:10.1016/S0923-1811(02)00152-4. PMID 12615366.
- Ishitani T, Takaesu G, Ninomiya-Tsuji J et al. (2004). "Role of the TAB2-related protein TAB3 in IL-1 and TNF signaling.". EMBO J. 22 (23): 6277–88. doi:10.1093/emboj/cdg605. PMC 291846. PMID 14633987.
- Cheung PC, Nebreda AR, Cohen P (2004). "TAB3, a new binding partner of the protein kinase TAK1.". Biochem. J. 378 (Pt 1): 27–34. doi:10.1042/BJ20031794. PMC 1223947. PMID 14670075.
- Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Bouwmeester T, Bauch A, Ruffner H et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway.". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216.
External links
|