T-box transcription factor TBX2 is a protein that in humans is encoded by the TBX2gene.[1][2]
This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene product is the human homolog of mouse Tbx2, and shares strong sequence similarity with Drosophila omb protein. Expression studies indicate that this gene may have a potential role in tumorigenesis as an immortalizing agent. Transcript heterogeneity due to alternative polyadenylation has been noted for this gene.[2]
^Campbell C, Goodrich K, Casey G, Beatty B (Feb 1996). "Cloning and mapping of a human gene (TBX2) sharing a highly conserved protein motif with the Drosophila omb gene". Genomics28 (2): 255–60. doi:10.1006/geno.1995.1139. PMID8530034.
^Carreira S, Liu B, Goding CR (2000). "The gene encoding the T-box factor Tbx2 is a target for the microphthalmia-associated transcription factor in melanocytes". J. Biol. Chem.275 (29): 21920–7. doi:10.1074/jbc.M000035200. PMID10770922.
^Hoek KS, Schlegel NC, Eichhoff OM, Widmer DS, Praetorius C, Einarsson SO, Valgeirsdottir S, Bergsteinsdottir K, Schepsky A, Dummer R, Steingrimsson E (December 2008). "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell Melanoma Res21 (6): 665–76. doi:10.1111/j.1755-148X.2008.00505.x. PMID19067971.
Further reading
Law DJ, Gebuhr T, Garvey N et al. (1996). "Identification, characterization, and localization to chromosome 17q21-22 of the human TBX2 homolog, member of a conserved developmental gene family.". Mamm. Genome6 (11): 793–7. doi:10.1007/BF00539006. PMID8597636.CS1 maint: Explicit use of et al. (link)
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res.6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID8889548.
Campbell CE, Casey G, Goodrich K (1998). "Genomic structure of TBX2 indicates conservation with distantly related T-box genes.". Mamm. Genome9 (1): 70–3. doi:10.1007/s003359900682. PMID9434949.
Sinha S, Abraham S, Gronostajski RM, Campbell CE (2001). "Differential DNA binding and transcription modulation by three T-box proteins, T, TBX1 and TBX2.". Gene258 (1-2): 15–29. doi:10.1016/S0378-1119(00)00417-0. PMID11111039.
Brummelkamp TR, Kortlever RM, Lingbeek M et al. (2002). "TBX-3, the gene mutated in Ulnar-Mammary Syndrome, is a negative regulator of p19ARF and inhibits senescence.". J. Biol. Chem.277 (8): 6567–72. doi:10.1074/jbc.M110492200. PMID11748239.CS1 maint: Explicit use of et al. (link)
Lingbeek ME, Jacobs JJ, van Lohuizen M (2002). "The T-box repressors TBX2 and TBX3 specifically regulate the tumor suppressor gene p14ARF via a variant T-site in the initiator.". J. Biol. Chem.277 (29): 26120–7. doi:10.1074/jbc.M200403200. PMID12000749.
Andelfinger G, Etter L, Dyment M et al. (2004). "Radiation hybrid mapping and genomic organization of canine TBX2 and TBX4.". Anim. Genet.34 (4): 307–9. doi:10.1046/j.1365-2052.2003.01018.x. PMID12873224.CS1 maint: Explicit use of et al. (link)
Borke JL, Yu JC, Isales CM et al. (2004). "Tension-induced reduction in connexin 43 expression in cranial sutures is linked to transcriptional regulation by TBX2.". Annals of plastic surgery51 (5): 499–504. doi:10.1097/01.SAP.0000067964.14122.3E. PMID14595187.CS1 maint: Explicit use of et al. (link)
Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet.36 (1): 40–5. doi:10.1038/ng1285. PMID14702039.CS1 maint: Explicit use of et al. (link)
Vance KW, Carreira S, Brosch G, Goding CR (2005). "Tbx2 is overexpressed and plays an important role in maintaining proliferation and suppression of senescence in melanomas.". Cancer Res.65 (6): 2260–8. doi:10.1158/0008-5472.CAN-04-3045. PMID15781639.