COUP-TF1 (COUP Transcription Factor 1) also known as NR2F1 (Nuclear Receptor subfamily 2, group F, member 1) is a protein that in humans is encoded by the NR2F1 gene.[1][2] This protein is a member of nuclear hormone receptor family of steroid hormone receptors.
Function
Coup (chicken ovalbumin upstream promoter) transcription factor binds to the ovalbumin promoter and, in conjunction with another protein (S300-II) stimulates initiation of transcription.[3][4] COUP-TF1 binds to both direct repeats and palindromes of the 5'-AGGTCA-3' motif.[5]
Interactions
COUP-TFI has been shown to interact with:
References
- ^ "Entrez Gene: NR2F1 nuclear receptor subfamily 2, group F, member 1".
- ^ Qiu Y, Krishnan V, Zeng Z, Gilbert DJ, Copeland NG, Gibson L, Yang-Feng T, Jenkins NA, Tsai MJ, Tsai SY (September 1995). "Isolation, characterization, and chromosomal localization of mouse and human COUP-TF I and II genes". Genomics 29 (1): 240–6. doi:10.1006/geno.1995.1237. PMID 8530078.
- ^ Sagami I, Tsai SY, Wang H, Tsai MJ, O'Malley BW (1 December 1986). "Identification of two factors required for transcription of the ovalbumin gene". Mol. Cell. Biol. 6 (12): 4259–67. doi:10.1128/MCB.6.12.4259. PMC 367207. PMID 3796602.
- ^ Tsai SY, Sagami I, Wang H, Tsai MJ, O'Malley BW (August 1987). "Interactions between a DNA-binding transcription factor (COUP) and a non-DNA binding factor (S300-II)". Cell 50 (5): 701–9. doi:10.1016/0092-8674(87)90328-X. PMID 3040258.
- ^ Tsai SY, Tsai MJ (April 1997). "Chick ovalbumin upstream promoter-transcription factors (COUP-TFs): coming of age". Endocr. Rev. 18 (2): 229–40. doi:10.1210/er.18.2.229. PMID 9101138.
- ^ a b Avram D, Fields A, Pretty On Top K, Nevrivy DJ, Ishmael JE, Leid M (April 2000). "Isolation of a Novel Family of C2H2 Zinc Finger Proteins Implicated in Transcriptional Repression Mediated by Chicken Ovalbumin Upstream Promoter Transcription Factor (COUP-TF) Orphan Nuclear Receptors". J. Biol. Chem. 275 (14): 10315–22. doi:10.1074/jbc.275.14.10315. PMC 2819356. PMID 10744719.
- ^ Dressel U, Thormeyer D, Altincicek B, Paululat A, Eggert M, Schneider S, Tenbaum SP, Renkawitz R, Baniahmad A (1 May 1999). "Alien, a Highly Conserved Protein with Characteristics of a Corepressor for Members of the Nuclear Hormone Receptor Superfamily". Mol. Cell. Biol. 19 (5): 3383–94. PMC 84131. PMID 10207062.
- ^ Métivier R, Gay FA, Hübner MR, Flouriot G, Salbert G, Gannon F, Kah O, Pakdel F (July 2002). "Formation of an hERα–COUP-TFI complex enhances hERα AF-1 through Ser118 phosphorylation by MAPK". EMBO J. 21 (13): 3443–53. doi:10.1093/emboj/cdf344. PMC 126093. PMID 12093745.
Further reading
- Kliewer SA, Umesono K, Heyman RA et al. (1992). "Retinoid X receptor-COUP-TF interactions modulate retinoic acid signaling". Proc. Natl. Acad. Sci. U.S.A. 89 (4): 1448–52. doi:10.1073/pnas.89.4.1448. PMC 48468. PMID 1311101.
- Berrodin TJ, Marks MS, Ozato K et al. (1992). "Heterodimerization among thyroid hormone receptor, retinoic acid receptor, retinoid X receptor, chicken ovalbumin upstream promoter transcription factor, and an endogenous liver protein". Mol. Endocrinol. 6 (9): 1468–78. doi:10.1210/me.6.9.1468. PMID 1331778.
- Ing NH, Beekman JM, Tsai SY et al. (1992). "Members of the steroid hormone receptor superfamily interact with TFIIB (S300-II)". J. Biol. Chem. 267 (25): 17617–23. PMID 1517211.
- Wang LH, Tsai SY, Cook RG et al. (1989). "COUP transcription factor is a member of the steroid receptor superfamily". Nature 340 (6229): 163–6. doi:10.1038/340163a0. PMID 2739739.
- Miyajima N, Kadowaki Y, Fukushige S et al. (1989). "Identification of two novel members of erbA superfamily by molecular cloning: the gene products of the two are highly related to each other". Nucleic Acids Res. 16 (23): 11057–74. doi:10.1093/nar/16.23.11057. PMC 338996. PMID 2905047.
- Sawaya BE, Rohr O, Aunis D, Schaeffer E (1996). "Chicken ovalbumin upstream promoter transcription factor, a transcriptional activator of HIV-1 gene expression in human brain cells". J. Biol. Chem. 271 (38): 23572–6. doi:10.1074/jbc.271.38.23572. PMID 8798567.
- Rohr O, Aunis D, Schaeffer E (1998). "COUP-TF and Sp1 interact and cooperate in the transcriptional activation of the human immunodeficiency virus type 1 long terminal repeat in human microglial cells". J. Biol. Chem. 272 (49): 31149–55. doi:10.1074/jbc.272.49.31149. PMID 9388268.
- Dressel U, Thormeyer D, Altincicek B et al. (1999). "Alien, a Highly Conserved Protein with Characteristics of a Corepressor for Members of the Nuclear Hormone Receptor Superfamily". Mol. Cell. Biol. 19 (5): 3383–94. PMC 84131. PMID 10207062.
- Klinge CM, Kaur K, Swanson HI (2000). "The aryl hydrocarbon receptor interacts with estrogen receptor alpha and orphan receptors COUP-TFI and ERRalpha1". Arch. Biochem. Biophys. 373 (1): 163–74. doi:10.1006/abbi.1999.1552. PMID 10620335.
- Rohr O, Schwartz C, Hery C et al. (2000). "The nuclear receptor chicken ovalbumin upstream promoter transcription factor interacts with HIV-1 Tat and stimulates viral replication in human microglial cells". J. Biol. Chem. 275 (4): 2654–60. doi:10.1074/jbc.275.4.2654. PMID 10644726.
- Sugiyama T, Wang JC, Scott DK, Granner DK (2000). "Transcription activation by the orphan nuclear receptor, chicken ovalbumin upstream promoter-transcription factor I (COUP-TFI). Definition of the domain involved in the glucocorticoid response of the phosphoenolpyruvate carboxykinase gene". J. Biol. Chem. 275 (5): 3446–54. doi:10.1074/jbc.275.5.3446. PMID 10652338.
- Vlahou A, Flytzanis CN (2000). "Subcellular trafficking of the nuclear receptor COUP-TF in the early embryonic cell cycle". Dev. Biol. 218 (2): 284–98. doi:10.1006/dbio.1999.9456. PMID 10656770.
- Avram D, Fields A, Pretty On Top K et al. (2000). "Isolation of a Novel Family of C2H2 Zinc Finger Proteins Implicated in Transcriptional Repression Mediated by Chicken Ovalbumin Upstream Promoter Transcription Factor (COUP-TF) Orphan Nuclear Receptors". J. Biol. Chem. 275 (14): 10315–22. doi:10.1074/jbc.275.14.10315. PMC 2819356. PMID 10744719.
- Gay F, Anglade I, Gong Z, Salbert G (2001). "The LIM/homeodomain protein islet-1 modulates estrogen receptor functions". Mol. Endocrinol. 14 (10): 1627–48. doi:10.1210/me.14.10.1627. PMID 11043578.
- You M, Fischer M, Cho WK, Crabb D (2002). "Transcriptional control of the human aldehyde dehydrogenase 2 promoter by hepatocyte nuclear factor 4: inhibition by cyclic AMP and COUP transcription factors". Arch. Biochem. Biophys. 398 (1): 79–86. doi:10.1006/abbi.2001.2713. PMID 11811951.
- Lin F, Kolluri SK, Chen GQ, Zhang XK (2002). "Regulation of retinoic acid-induced inhibition of AP-1 activity by orphan receptor chicken ovalbumin upstream promoter-transcription factor". J. Biol. Chem. 277 (24): 21414–22. doi:10.1074/jbc.M201885200. PMID 11934895.
- Métivier R, Gay FA, Hübner MR et al. (2002). "Formation of an hERα–COUP-TFI complex enhances hERα AF-1 through Ser118 phosphorylation by MAPK". EMBO J. 21 (13): 3443–53. doi:10.1093/emboj/cdf344. PMC 126093. PMID 12093745.
- Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Yu X, Mertz JE (2003). "Distinct Modes of Regulation of Transcription of Hepatitis B Virus by the Nuclear Receptors HNF4α and COUP-TF1". J. Virol. 77 (4): 2489–99. doi:10.1128/JVI.77.4.2489-2499.2003. PMC 141100. PMID 12551987.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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