Folliculogenesis specific basic helix-loop-helix | |||||||||||||
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Identifiers | |||||||||||||
Symbols | FIGLA ; BHLHC8; FIGALPHA; POF6 | ||||||||||||
External IDs | OMIM: 608697 MGI: 1349421 HomoloGene: 49294 GeneCards: FIGLA Gene | ||||||||||||
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Orthologs | |||||||||||||
Species | Human | Mouse | |||||||||||
Entrez | 344018 | 26910 | |||||||||||
Ensembl | ENSG00000183733 | ENSMUSG00000030001 | |||||||||||
UniProt | Q6QHK4 | O55208 | |||||||||||
RefSeq (mRNA) | NM_001004311 | NM_012013 | |||||||||||
RefSeq (protein) | NP_001004311 | NP_036143 | |||||||||||
Location (UCSC) | Chr 2: 71 – 71.02 Mb |
Chr 6: 86.02 – 86.02 Mb |
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PubMed search | [1] | [2] | |||||||||||
Folliculogenesis-specific basic helix-loop-helix, also known as factor in the germline alpha (FIGalpha) or transcription factor FIGa, is a protein that in humans is encoded by the FIGLA gene.[1][2]
Function
This gene encodes a protein that functions in postnatal oocyte-specific gene expression. The protein is a basic helix-loop-helix transcription factor that regulates multiple oocyte-specific genes, including genes involved in folliculogenesis and those that encode the zona pellucida.[1]
Clinical significance
Mutation in the FIGLA gene are associated with premature ovarian failure.[3]
References
- ^ a b "Entrez Gene: folliculogenesis specific basic helix-loop-helix".
- ^ Huntriss J, Gosden R, Hinkins M, Oliver B, Miller D, Rutherford AJ, Picton HM (December 2002). "Isolation, characterization and expression of the human Factor In the Germline alpha (FIGLA) gene in ovarian follicles and oocytes". Mol. Hum. Reprod. 8 (12): 1087–95. doi:10.1093/molehr/8.12.1087. PMID 12468641.
- ^ Zhao H, Chen ZJ, Qin Y et al. (June 2008). "Transcription factor FIGLA is mutated in patients with premature ovarian failure". Am. J. Hum. Genet. 82 (6): 1342–8. doi:10.1016/j.ajhg.2008.04.018. PMC 2427265. PMID 18499083.
Further reading
- Miyamoto T, Sengoku K, Takuma N et al. (2002). "Isolation and expression analysis of the testis-specific gene, STRA8, stimulated by retinoic acid gene 8.". J. Assist. Reprod. Genet. 19 (11): 531–5. PMC 3455343. PMID 12489526.
- Suzumori N, Pangas SA, Rajkovic A (2007). "Candidate genes for premature ovarian failure.". Curr. Med. Chem. 14 (3): 353–7. doi:10.2174/092986707779941087. PMID 17305537.
- Törmälä RM, Jääskeläinen M, Lakkakorpi J et al. (2008). "Zona pellucida components are present in human fetal ovary before follicle formation.". Mol. Cell. Endocrinol. 289 (1-2): 10–5. doi:10.1016/j.mce.2008.01.029. PMID 18502569.
- Gerhard DS, Wagner L, Feingold EA et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Zhao H, Chen ZJ, Qin Y et al. (2008). "Transcription factor FIGLA is mutated in patients with premature ovarian failure.". Am. J. Hum. Genet. 82 (6): 1342–8. doi:10.1016/j.ajhg.2008.04.018. PMC 2427265. PMID 18499083.
- Pangas SA, Rajkovic A. "Transcriptional regulation of early oogenesis: in search of masters.". Hum. Reprod. Update 12 (1): 65–76. doi:10.1093/humupd/dmi033. PMID 16143663.
- van Dooren MF, Bertoli-Avellab AM, Oldenburg RA (2009). "Premature ovarian failure and gene polymorphisms.". Curr. Opin. Obstet. Gynecol. 21 (4): 313–7. PMID 19610175.
- Strausberg RL, Feingold EA, Grouse LH et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Fowler PA, Flannigan S, Mathers A et al. (2009). "Gene expression analysis of human fetal ovarian primordial follicle formation.". J. Clin. Endocrinol. Metab. 94 (4): 1427–35. doi:10.1210/jc.2008-2619. PMID 19258411.
- Bayne RA, Martins da Silva SJ, Anderson RA (2004). "Increased expression of the FIGLA transcription factor is associated with primordial follicle formation in the human fetal ovary.". Mol. Hum. Reprod. 10 (6): 373–81. doi:10.1093/molehr/gah056. PMID 15044608.
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