Transcription factor SOX-5 is a protein that in humans is encoded by the SOX5gene.[1][2]
This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. The encoded protein may play a role in chondrogenesis. A pseudogene of this gene is located on chromosome 8. Multiple transcript variants encoding distinct isoforms have been identified for this gene.[2]
^Wunderle VM, Critcher R, Ashworth A, Goodfellow PN (Jan 1997). "Cloning and characterization of SOX5, a new member of the human SOX gene family". Genomics36 (2): 354–8. doi:10.1006/geno.1996.0474. PMID8812465.
Kamachi Y, Uchikawa M, Kondoh H (2000). "Pairing SOX off: with partners in the regulation of embryonic development.". Trends Genet.16 (4): 182–7. doi:10.1016/S0168-9525(99)01955-1. PMID10729834.
Bowles J, Schepers G, Koopman P (2001). "Phylogeny of the SOX family of developmental transcription factors based on sequence and structural indicators.". Dev. Biol.227 (2): 239–55. doi:10.1006/dbio.2000.9883. PMID11071752.
Wilson M, Koopman P (2003). "Matching SOX: partner proteins and co-factors of the SOX family of transcriptional regulators.". Curr. Opin. Genet. Dev.12 (4): 441–6. doi:10.1016/S0959-437X(02)00323-4. PMID12100890.
Schepers GE, Teasdale RD, Koopman P (2002). "Twenty pairs of sox: extent, homology, and nomenclature of the mouse and human sox transcription factor gene families.". Dev. Cell3 (2): 167–70. doi:10.1016/S1534-5807(02)00223-X. PMID12194848.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID8125298.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res.6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID8889548.
Suzuki Y; Yoshitomo-Nakagawa K; Maruyama K et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID9373149.Cite uses deprecated parameter |author-separator= (help)
Uusitalo H; Hiltunen A; Ahonen M et al. (2002). "Accelerated up-regulation of L-Sox5, Sox6, and Sox9 by BMP-2 gene transfer during murine fracture healing". J. Bone Miner. Res.16 (10): 1837–45. doi:10.1359/jbmr.2001.16.10.1837. PMID11585348.Cite uses deprecated parameter |author-separator= (help)
Zafarana G; Gillis AJ; van Gurp RJ et al. (2002). "Coamplification of DAD-R, SOX5, and EKI1 in human testicular seminomas, with specific overexpression of DAD-R, correlates with reduced levels of apoptosis and earlier clinical manifestation". Cancer Res.62 (6): 1822–31. PMID11912161.Cite uses deprecated parameter |author-separator= (help)
Ikeda T; Zhang J; Chano T et al. (2003). "Identification and characterization of the human long form of Sox5 (L-SOX5) gene". Gene298 (1): 59–68. doi:10.1016/S0378-1119(02)00927-7. PMID12406576.Cite uses deprecated parameter |author-separator= (help)
Ota T; Suzuki Y; Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet.36 (1): 40–5. doi:10.1038/ng1285. PMID14702039.Cite uses deprecated parameter |author-separator= (help)
PDB gallery
1i11: SOLUTION STRUCTURE OF THE DNA BINDING DOMAIN, SOX-5 HMG BOX FROM MOUSE