Transcription factor E2F3 is a protein that in humans is encoded by the E2F3 gene.[1]
The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F1 and E2F2, have an additional cyclin binding domain. This protein binds specifically to retinoblastoma protein pRB in a cell-cycle dependent manner. Alternative gene splicing is found in the mouse homolog, but has not reported in human yet.[2]
Interactions
E2F3 has been shown to interact with TFE3[3] and RYBP.[4]
See also
References
- ^ Lees JA, Saito M, Vidal M, Valentine M, Look T, Harlow E, Dyson N, Helin K (Jan 1994). "The retinoblastoma protein binds to a family of E2F transcription factors". Mol Cell Biol 13 (12): 7813–25. PMC 364853. PMID 8246996.
- ^ "Entrez Gene: E2F3 E2F transcription factor 3".
- ^ Giangrande, Paloma H; Hallstrom Timothy C; Tunyaplin Chainarong; Calame Kathryn; Nevins Joseph R (Jun 2003). "Identification of E-box factor TFE3 as a functional partner for the E2F3 transcription factor". Mol. Cell. Biol. (United States) 23 (11): 3707–20. doi:10.1128/MCB.23.11.3707-3720.2003. ISSN 0270-7306. PMC 155231. PMID 12748276.
- ^ Schlisio, Susanne; Halperin Terri; Vidal Miguel; Nevins Joseph R (Nov 2002). "Interaction of YY1 with E2Fs, mediated by RYBP, provides a mechanism for specificity of E2F function". EMBO J. (England) 21 (21): 5775–86. doi:10.1093/emboj/cdf577. ISSN 0261-4189. PMC 131074. PMID 12411495.
Further reading
- Nomura N, Nagase T, Miyajima N et al. (1995). "Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1.". DNA Res. 1 (5): 223–9. doi:10.1093/dnares/1.5.223. PMID 7584044.
- Wu CL, Zukerberg LR, Ngwu C et al. (1995). "In vivo association of E2F and DP family proteins.". Mol. Cell. Biol. 15 (5): 2536–46. PMC 230484. PMID 7739537.
- Karlseder J, Rotheneder H, Wintersberger E (1996). "Interaction of Sp1 with the growth- and cell cycle-regulated transcription factor E2F.". Mol. Cell. Biol. 16 (4): 1659–67. PMC 231152. PMID 8657141.
- Rogers KT, Higgins PD, Milla MM et al. (1996). "DP-2, a heterodimeric partner of E2F: identification and characterization of DP-2 proteins expressed in vivo.". Proc. Natl. Acad. Sci. U.S.A. 93 (15): 7594–9. doi:10.1073/pnas.93.15.7594. PMC 38791. PMID 8755520.
- Magae J, Wu CL, Illenye S et al. (1997). "Nuclear localization of DP and E2F transcription factors by heterodimeric partners and retinoblastoma protein family members.". J. Cell. Sci. 109 (7): 1717–26. PMID 8832394.
- Hofmann F, Livingston DM (1996). "Differential effects of cdk2 and cdk3 on the control of pRb and E2F function during G1 exit.". Genes Dev. 10 (7): 851–61. doi:10.1101/gad.10.7.851. PMID 8846921.
- Lindeman GJ, Gaubatz S, Livingston DM, Ginsberg D (1997). "The subcellular localization of E2F-4 is cell-cycle dependent.". Proc. Natl. Acad. Sci. U.S.A. 94 (10): 5095–100. doi:10.1073/pnas.94.10.5095. PMC 24637. PMID 9144196.
- Dynlacht BD, Moberg K, Lees JA et al. (1997). "Specific regulation of E2F family members by cyclin-dependent kinases.". Mol. Cell. Biol. 17 (7): 3867–75. PMC 232239. PMID 9199321.
- Pierce AM, Schneider-Broussard R, Philhower JL, Johnson DG (1998). "Differential activities of E2F family members: unique functions in regulating transcription.". Mol. Carcinog. 22 (3): 190–8. doi:10.1002/(SICI)1098-2744(199807)22:3<190::AID-MC7>3.0.CO;2-P. PMID 9688145.
- Humbert PO, Verona R, Trimarchi JM et al. (2000). "E2f3 is critical for normal cellular proliferation.". Genes Dev. 14 (6): 690–703. PMC 316459. PMID 10733529.
- Takahashi Y, Rayman JB, Dynlacht BD (2000). "Analysis of promoter binding by the E2F and pRB families in vivo: distinct E2F proteins mediate activation and repression.". Genes Dev. 14 (7): 804–16. PMC 316494. PMID 10766737.
- Leone G, Nuckolls F, Ishida S et al. (2000). "Identification of a novel E2F3 product suggests a mechanism for determining specificity of repression by Rb proteins.". Mol. Cell. Biol. 20 (10): 3626–32. doi:10.1128/MCB.20.10.3626-3632.2000. PMC 85655. PMID 10779352.
- He Y, Armanious MK, Thomas MJ, Cress WD (2000). "Identification of E2F-3B, an alternative form of E2F-3 lacking a conserved N-terminal region.". Oncogene 19 (30): 3422–33. doi:10.1038/sj.onc.1203682. PMID 10918599.
- Yamochi T, Semba K, Tsuji K et al. (2002). "ik3-1/Cables is a substrate for cyclin-dependent kinase 3 (cdk 3).". Eur. J. Biochem. 268 (23): 6076–82. doi:10.1046/j.0014-2956.2001.02555.x. PMID 11733001.
- Weinmann AS, Yan PS, Oberley MJ et al. (2002). "Isolating human transcription factor targets by coupling chromatin immunoprecipitation and CpG island microarray analysis.". Genes Dev. 16 (2): 235–44. doi:10.1101/gad.943102. PMC 155318. PMID 11799066.
- Ren B, Cam H, Takahashi Y et al. (2002). "E2F integrates cell cycle progression with DNA repair, replication, and G(2)/M checkpoints.". Genes Dev. 16 (2): 245–56. doi:10.1101/gad.949802. PMC 155321. PMID 11799067.
- He Y, Cress WD (2002). "E2F-3B is a physiological target of cyclin A.". J. Biol. Chem. 277 (26): 23493–9. doi:10.1074/jbc.M202629200. PMID 11980909.
- Schlisio S, Halperin T, Vidal M, Nevins JR (2002). "Interaction of YY1 with E2Fs, mediated by RYBP, provides a mechanism for specificity of E2F function.". EMBO J. 21 (21): 5775–86. doi:10.1093/emboj/cdf577. PMC 131074. PMID 12411495.
- Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
External links
- E2F3 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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