Transcription factor SOX-6 is a protein that in humans is encoded by the SOX6 gene.[1][2]
The SOX gene family encodes a group of transcription factors defined by the conserved high mobility group (HMG) DNA-binding domain. Unlike most transcription factors, SOX transcription factors bind to the minor groove of DNA, causing a 70- to 85-degree bend and introducing local conformational changes.[supplied by OMIM][2]
Interactions
SOX6 has been shown to interact with CTBP2[3] and CENPK.[4]
It has also been demonstrated that SOX6 protein accumulates in the differentiating human erythrocytes, and then is able to downregulate its own transcription, by directly binding to an evolutionarily conserved consensus sequences located near SOX6 transcriptional start site.[5]
See also
References
- ^ Cohen-Barak O, Hagiwara N, Arlt MF, Horton JP, Brilliant MH (Mar 2001). "Cloning, characterization and chromosome mapping of the human SOX6 gene". Gene 265 (1–2): 157–64. doi:10.1016/S0378-1119(01)00346-8. PMID 11255018.
- ^ a b "Entrez Gene: SOX6 SRY (sex determining region Y)-box 6".
- ^ Murakami A, Ishida S, Thurlow J, Revest JM, Dickson C (August 2001). "SOX6 binds CtBP2 to repress transcription from the Fgf-3 promoter". Nucleic Acids Res. 29 (16): 3347–55. doi:10.1093/nar/29.16.3347. PMC 55854. PMID 11504872.
- ^ Yamashita A, Ito M, Takamatsu N, Shiba T (September 2000). "Characterization of Solt, a novel SoxLZ/Sox6 binding protein expressed in adult mouse testis". FEBS Lett. 481 (2): 147–51. doi:10.1016/S0014-5793(00)01987-6. PMID 10996314.
- ^ Cantu' C, Grande V, Alborelli I, Cassinelli L, Cantu' I, Colzani MT, Ierardi R, Ronzoni L, Cappellini MD, Ferrari G, Ottolenghi S, Ronchi A (September 2010). "A highly conserved SOX6 double binding site mediates SOX6 gene downregulation in erythroid cells". Nucleic Acids Res. 39 (2): 486–501. doi:10.1093/nar/gkq819. PMC 3025548. PMID 20852263.
Further reading
- Denny P, Swift S, Brand N et al. (1992). "A conserved family of genes related to the testis determining gene, SRY". Nucleic Acids Res. 20 (11): 2887. doi:10.1093/nar/20.11.2887. PMC 336939. PMID 1614875.
- Lefebvre V, Li P, de Crombrugghe B (1998). "A new long form of Sox5 (L-Sox5), Sox6 and Sox9 are coexpressed in chondrogenesis and cooperatively activate the type II collagen gene". EMBO J. 17 (19): 5718–33. doi:10.1093/emboj/17.19.5718. PMC 1170900. PMID 9755172.
- Hagiwara N, Klewer SE, Samson RA et al. (2000). "Sox6 is a candidate gene for p100H myopathy, heart block, and sudden neonatal death". Proc. Natl. Acad. Sci. U.S.A. 97 (8): 4180–5. doi:10.1073/pnas.97.8.4180. PMC 18189. PMID 10760285.
- Yamashita A, Ito M, Takamatsu N, Shiba T (2000). "Characterization of Solt, a novel SoxLZ/Sox6 binding protein expressed in adult mouse testis". FEBS Lett. 481 (2): 147–51. doi:10.1016/S0014-5793(00)01987-6. PMID 10996314.
- Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
- Wiemann S, Weil B, Wellenreuther R et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
- Murakami A, Ishida S, Thurlow J et al. (2001). "SOX6 binds CtBP2 to repress transcription from the Fgf-3 promoter". Nucleic Acids Res. 29 (16): 3347–55. doi:10.1093/nar/29.16.3347. PMC 55854. PMID 11504872.
- Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Cohen-Barak O, Yi Z, Hagiwara N et al. (2004). "Sox6 regulation of cardiac myocyte development". Nucleic Acids Res. 31 (20): 5941–8. doi:10.1093/nar/gkg807. PMC 219484. PMID 14530442.
- Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Wiemann S, Arlt D, Huber W et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
- Ueda R, Yoshida K, Kawakami Y et al. (2005). "Expression of a transcriptional factor, SOX6, in human gliomas". Brain tumor pathology 21 (1): 35–8. doi:10.1007/BF02482175. PMID 15696967.
- Ueda R, Yoshida K, Kawakami Y et al. (2005). "Immunohistochemical analysis of SOX6 expression in human brain tumors". Brain tumor pathology 21 (3): 117–20. doi:10.1007/BF02482186. PMID 15696972.
- Mehrle A, Rosenfelder H, Schupp I et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
- Fernández-Lloris R, Osses N, Jaffray E et al. (2006). "Repression of SOX6 transcriptional activity by SUMO modification". FEBS Lett. 580 (5): 1215–21. doi:10.1016/j.febslet.2006.01.031. PMID 16442531.
- Ikeda T, Saito T, Ushita M et al. (2007). "Identification and characterization of the human SOX6 promoter". Biochem. Biophys. Res. Commun. 357 (2): 383–90. doi:10.1016/j.bbrc.2007.03.133. PMID 17433257.
External links
- SOX6 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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