CCAAT/enhancer binding protein (C/EBP), delta | |||||||||||||
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Identifiers | |||||||||||||
Symbols | CEBPD ; C/EBP-delta; CELF; CRP3; NF-IL6-beta | ||||||||||||
External IDs | OMIM: 116898 MGI: 103573 HomoloGene: 3808 GeneCards: CEBPD Gene | ||||||||||||
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Orthologs | |||||||||||||
Species | Human | Mouse | |||||||||||
Entrez | 1052 | 12609 | |||||||||||
Ensembl | ENSG00000221869 | n/a | |||||||||||
UniProt | P49716 | Q00322 | |||||||||||
RefSeq (mRNA) | NM_005195 | NM_007679 | |||||||||||
RefSeq (protein) | NP_005186 | NP_031705 | |||||||||||
Location (UCSC) | Chr 8: 48.65 – 48.65 Mb |
n/a | |||||||||||
PubMed search | [1] | [2] | |||||||||||
CCAAT/enhancer-binding protein delta is a protein that in humans is encoded by the CEBPD gene.[1][2]
The protein encoded by this intronless gene is a bZIP transcription factor which can bind as a homodimer to certain DNA regulatory regions. It can also form heterodimers with the related protein CEBP-alpha. The encoded protein is important in the regulation of genes involved in immune and inflammatory responses, and may be involved in the regulation of genes associated with activation and/or differentiation of macrophages.[3]
Functions
CEBPD is involved in regulation of apoptosis and cell proliferation. It probably acts as tumor suppressor. [4]
One study in mice showed that CEBPD prevents development of tubular injury and tubulointerstitial fibrogenesis during the progression of chronic obstructive nephropathy. [5]
Interactions
CEBPD has been shown to interact with Mothers against decapentaplegic homolog 3.[6]
See also
References
- ^ Cao Z, Umek RM, McKnight SL (October 1991). "Regulated expression of three C/EBP isoforms during adipose conversion of 3T3-L1 cells". Genes Dev 5 (9): 1538–52. doi:10.1101/gad.5.9.1538. PMID 1840554.
- ^ Williams SC, Cantwell CA, Johnson PF (October 1991). "A family of C/EBP-related proteins capable of forming covalently linked leucine zipper dimers in vitro". Genes Dev 5 (9): 1553–67. doi:10.1101/gad.5.9.1553. PMID 1884998.
- ^ "Entrez Gene: CEBPD CCAAT/enhancer binding protein (C/EBP), delta".
- ^ Gery s (2005). "C/EBPdelta expression in a BCR-ABL-positive cell line induces growth arrest and myeloid differentiation". Oncogene. 24 (9): 1589–97. doi:10.1038/sj.onc.1208393. PMID 15674331.
- ^ Duitman J (Jan 2014). "CCAAT-enhancer binding protein delta (C/EBPδ) attenuates tubular injury and tubulointerstitial fibrogenesis during chronic obstructive nephropathy". Lab Invest. 94 (1): 89–97. doi:10.1038/labinvest.2013.127. PMID 24247561.
- ^ Choy, Lisa; Derynck Rik (March 2003). "Transforming growth factor-beta inhibits adipocyte differentiation by Smad3 interacting with CCAAT/enhancer-binding protein (C/EBP) and repressing C/EBP transactivation function". J. Biol. Chem. (United States) 278 (11): 9609–19. doi:10.1074/jbc.M212259200. ISSN 0021-9258. PMID 12524424.
Further reading
- Sladek FM, Darnell JE (1992). "Mechanisms of liver-specific gene expression.". Curr. Opin. Genet. Dev. 2 (2): 256–9. doi:10.1016/S0959-437X(05)80282-5. PMID 1638120.
- Kinoshita S, Akira S, Kishimoto T (1992). "A member of the C/EBP family, NF-IL6 beta, forms a heterodimer and transcriptionally synergizes with NF-IL6.". Proc. Natl. Acad. Sci. U.S.A. 89 (4): 1473–6. doi:10.1073/pnas.89.4.1473. PMC 48473. PMID 1741402.
- Nagulapalli S, Pongubala JM, Atchison ML (1995). "Multiple proteins physically interact with PU.1. Transcriptional synergy with NF-IL6 beta (C/EBP delta, CRP3).". J. Immunol. 155 (9): 4330–8. PMID 7594592.
- Wood S, Schertzer M, Yaremko ML (1995). "Sequence identity locates CEBPD and FGFR1 to mapped human loci within proximal 8p.". Cytogenet. Cell Genet. 70 (3–4): 188–91. doi:10.1159/000134030. PMID 7789168.
- Cleutjens CB, van Eekelen CC, van Dekken H et al. (1993). "The human C/EBP delta (CRP3/CELF) gene: structure and chromosomal localization". Genomics 16 (2): 520–3. doi:10.1006/geno.1993.1220. PMID 8314590.
- Chen PL, Riley DJ, Chen Y, Lee WH (1997). "Retinoblastoma protein positively regulates terminal adipocyte differentiation through direct interaction with C/EBPs". Genes Dev. 10 (21): 2794–804. doi:10.1101/gad.10.21.2794. PMID 8946919.
- Xia C, Cheshire JK, Patel H, Woo P (1998). "Cross-talk between transcription factors NF-kappa B and C/EBP in the transcriptional regulation of genes". Int. J. Biochem. Cell Biol. 29 (12): 1525–39. doi:10.1016/S1357-2725(97)00083-6. PMID 9570146.
- Zhu Y, Saunders MA, Yeh H et al. (2002). "Dynamic regulation of cyclooxygenase-2 promoter activity by isoforms of CCAAT/enhancer-binding proteins". J. Biol. Chem. 277 (9): 6923–8. doi:10.1074/jbc.M108075200. PMID 11741938.
- Angeloni D, Lee JD, Johnson BE et al. (2002). "C306A single nucleotide polymorphism in the human CEBPD gene that maps at 8p11.1-p11.2". Mol. Cell. Probes 15 (6): 395–7. doi:10.1006/mcpr.2001.0377. PMID 11851384.
- Gao H, Parkin S, Johnson PF, Schwartz RC (2002). "C/EBP gamma has a stimulatory role on the IL-6 and IL-8 promoters". J. Biol. Chem. 277 (41): 38827–37. doi:10.1074/jbc.M206224200. PMID 12177065.
- Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Dearth LR, DeWille J (2003). "Posttranscriptional and posttranslational regulation of C/EBP delta in G0 growth-arrested mammary epithelial cells". J. Biol. Chem. 278 (13): 11246–55. doi:10.1074/jbc.M207930200. PMID 12554732.
- Milde-Langosch K, Löning T, Bamberger AM (2003). "Expression of the CCAAT/enhancer-binding proteins C/EBPalpha, C/EBPbeta and C/EBPdelta in breast cancer: correlations with clinicopathologic parameters and cell-cycle regulatory proteins". Breast Cancer Res. Treat. 79 (2): 175–85. doi:10.1023/A:1023929504884. PMID 12825852.
- Kovács KA, Steinmann M, Magistretti PJ et al. (2003). "CCAAT/enhancer-binding protein family members recruit the coactivator CREB-binding protein and trigger its phosphorylation". J. Biol. Chem. 278 (38): 36959–65. doi:10.1074/jbc.M303147200. PMID 12857754.
- Chen YW, Hubal MJ, Hoffman EP et al. (2004). "Molecular responses of human muscle to eccentric exercise". J. Appl. Physiol. 95 (6): 2485–94. doi:10.1152/japplphysiol.01161.2002. PMID 12937035.
- Li R, Strohmeyer R, Liang Z et al. (2004). "CCAAT/enhancer binding protein delta (C/EBPdelta) expression and elevation in Alzheimer's disease". Neurobiol. Aging 25 (8): 991–9. doi:10.1016/j.neurobiolaging.2003.10.016. PMID 15212823.
- Sivko GS, Sanford DC, Dearth LD et al. (2005). "CCAAT/Enhancer binding protein delta (c/EBPdelta) regulation and expression in human mammary epithelial cells: II. Analysis of activating signal transduction pathways, transcriptional, post-transcriptional, and post-translational control". J. Cell. Biochem. 93 (4): 844–56. doi:10.1002/jcb.20224. PMID 15389878.
External links
- CEBPD protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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