Apetala 2 (AP2) is a gene coding for a member of a large family of transcription factors, the AP2/EREBP family. In Arabidopsis thaliana which plays a role in the ABC model of flower development .[ 2] It was originally thought that this family of proteins was plant-specific, however recent studies have shown that apicomplexans , including the causative agent of malaria , Plasmodium falciparum encode a related set of transcription factors, called the ApiAP2 family.[ 3]
In the A. thaliana transcription factor RAV 1 the N-terminal AP2 domain binds 5'- CAACA-3' sequence, while the C-terminal highly conserved B3 domain binds 5'- CACCTG-3' sequence.[ 4]
References
^ Allen MD, Yamasaki K, Ohme-Takagi M, Tateno M, Suzuki M (September 1998). "A novel mode of DNA recognition by a beta-sheet revealed by the solution structure of the GCC-box binding domain in complex with DNA" . EMBO J. 17 (18): 5484–96. doi :10.1093/emboj/17.18.5484 . PMC 1170874 . PMID 9736626 .
^ Riechmann JL, Meyerowitz EM (1998). "The AP2/EREBP family of plant transcription factors". Biol. Chem. 379 (6): 633–46. doi :10.1515/bchm.1998.379.6.633 . PMID 9687012 .
^ Balaji S, Babu MM, Iyer LM, Aravind L (2005). "Discovery of the principal specific transcription factors of Apicomplexa and their implication for the evolution of the AP2-integrase DNA binding domains" . Nucleic Acids Research 33 (13): 3994–4006. doi :10.1093/nar/gki709 . PMC 1178005 . PMID 16040597 .
^ Kagaya Y, Ohmiya K, Hattori T (1999). "RAV1, a novel DNA-binding protein, binds to bipartite recognition sequence through two distinct DNA-binding domains uniquely found in higher plants" . Nucleic Acids Res. 27 (2): 470–8. doi :10.1093/nar/27.2.470 . PMC 148202 . PMID 9862967 .
External links
(2.1) Nuclear receptor (Cys4 )
subfamily 1
subfamily 2
subfamily 3
subfamily 4
subfamily 5
subfamily 6
subfamily 0
(2.2) Other Cys4
(2.3) Cys2 His2
(2.4) Cys6
(2.5) Alternating composition
(2.6) WRKY
(4) β-Scaffold factors with minor groove contacts
(0) Other transcription factors
Index of genetics
Description
Disease