Kruppel-like factor 13 | |||||||||||||
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Identifiers | |||||||||||||
Symbols | KLF13 ; BTEB3; FKLF2; NSLP1; RFLAT-1; RFLAT1 | ||||||||||||
External IDs | OMIM: 605328 MGI: 1354948 HomoloGene: 32288 GeneCards: KLF13 Gene | ||||||||||||
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RNA expression pattern | |||||||||||||
More reference expression data | |||||||||||||
Orthologs | |||||||||||||
Species | Human | Mouse | |||||||||||
Entrez | 51621 | 50794 | |||||||||||
Ensembl | ENSG00000169926 | ENSMUSG00000052040 | |||||||||||
UniProt | Q9Y2Y9 | Q9JJZ6 | |||||||||||
RefSeq (mRNA) | NM_015995 | NM_021366 | |||||||||||
RefSeq (protein) | NP_057079 | NP_067341 | |||||||||||
Location (UCSC) | Chr 15: 31.62 – 31.73 Mb |
Chr 7: 63.89 – 63.94 Mb |
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PubMed search | [1] | [2] | |||||||||||
Kruppel-like factor 13, also known as KLF13, is a protein that in humans is encoded by the KLF13 gene.[1][2][3]
Function
KLF13 belongs to a family of transcription factors that contain 3 classical zinc finger DNA-binding domains consisting of a zinc atom tetrahedrally coordinated by 2 cysteines and 2 histidines (C2H2 motif). These transcription factors bind to GC-rich sequences and related GT and CACCC boxes.[1][4]
KLF13 was first described as the RANTES factor of late activated T lymphocytes (RFLAT)-1.[3] It regulates the expression of the chemokine RANTES in T lymphocytes. It functions as a lynchpin, inducing a large enhancesome. KLF13 knock-out mice show a defect in lymphocyte survival as KLF13 is a regulator of Bcl-xL expression.[3][5][6][7][8][9][10]
Interactions
KLF13 has been shown to interact with CREB-binding protein,[11] Heat shock protein 47[11] and PCAF.[11]
See also
References
- ^ a b "Entrez Gene: KLF13 Kruppel-like factor 13".
- ^ Cook T, Gebelein B, Urrutia R (June 1999). "Sp1 and its likes: biochemical and functional predictions for a growing family of zinc finger transcription factors". Ann. N. Y. Acad. Sci. 880 (1 CELL AND MOLE): 94–102. doi:10.1111/j.1749-6632.1999.tb09513.x. PMID 10415854.
- ^ a b c Song A, Chen YF, Thamatrakoln K, Storm TA, Krensky AM (January 1999). "RFLAT-1: a new zinc finger transcription factor that activates RANTES gene expression in T lymphocytes". Immunity 10 (1): 93–103. doi:10.1016/S1074-7613(00)80010-2. PMID 10023774.
- ^ Scohy S, Gabant P, Van Reeth T, Hertveldt V, Drèze PL, Van Vooren P, Rivière M, Szpirer J, Szpirer C (November 2000). "Identification of KLF13 and KLF14 (SP6), novel members of the SP/XKLF transcription factor family". Genomics 70 (1): 93–101. doi:10.1006/geno.2000.6362. PMID 11087666.
- ^ Song A, Nikolcheva T, Krensky AM (October 2000). "Transcriptional regulation of RANTES expression in T lymphocytes". Immunol. Rev. 177 (1): 236–45. doi:10.1034/j.1600-065X.2000.17610.x. PMID 11138780.
- ^ Nikolcheva T, Pyronnet S, Chou SY, Sonenberg N, Song A, Clayberger C, Krensky AM (July 2002). "A translational rheostat for RFLAT-1 regulates RANTES expression in T lymphocytes". J. Clin. Invest. 110 (1): 119–26. doi:10.1172/JCI15336. PMC 151028. PMID 12093895.
- ^ Song A, Patel A, Thamatrakoln K, Liu C, Feng D, Clayberger C, Krensky AM (August 2002). "Functional domains and DNA-binding sequences of RFLAT-1/KLF13, a Krüppel-like transcription factor of activated T lymphocytes". J. Biol. Chem. 277 (33): 30055–65. doi:10.1074/jbc.M204278200. PMID 12050170.
- ^ Zhou M, McPherson L, Feng D, Song A, Dong C, Lyu SC, Zhou L, Shi X, Ahn YT, Wang D, Clayberger C, Krensky AM (May 2007). "Kruppel-like transcription factor 13 regulates T lymphocyte survival in vivo". J. Immunol. 178 (9): 5496–504. doi:10.4049/jimmunol.178.9.5496. PMC 2664650. PMID 17442931.
- ^ Huang B, Ahn YT, McPherson L, Clayberger C, Krensky AM (June 2007). "Interaction of PRP4 with Kruppel-like factor 13 regulates CCL5 transcription". J. Immunol. 178 (11): 7081–7. doi:10.4049/jimmunol.178.11.7081. PMC 2674583. PMID 17513757.
- ^ Ahn YT, Huang B, McPherson L, Clayberger C, Krensky AM (January 2007). "Dynamic interplay of transcriptional machinery and chromatin regulates "late" expression of the chemokine RANTES in T lymphocytes". Mol. Cell. Biol. 27 (1): 253–66. doi:10.1128/MCB.01071-06. PMC 1800668. PMID 17074812.
- ^ a b c Song, Chao-Zhong; Keller Kimberly; Murata Ken; Asano Haruhiko; Stamatoyannopoulos George (Mar 2002). "Functional interaction between coactivators CBP/p300, PCAF, and transcription factor FKLF2". J. Biol. Chem. (United States) 277 (9): 7029–36. doi:10.1074/jbc.M108826200. ISSN 0021-9258. PMC 2808425. PMID 11748222.
Further reading
- Cook T, Gebelein B, Urrutia R (1999). "Sp1 and its likes: biochemical and functional predictions for a growing family of zinc finger transcription factors.". Ann. N. Y. Acad. Sci. 880 (1 CELL AND MOLE): 94–102. doi:10.1111/j.1749-6632.1999.tb09513.x. PMID 10415854.
- Song A, Chen YF, Thamatrakoln K et al. (1999). "RFLAT-1: a new zinc finger transcription factor that activates RANTES gene expression in T lymphocytes.". Immunity 10 (1): 93–103. doi:10.1016/S1074-7613(00)80010-2. PMID 10023774.
- Asano H, Li XS, Stamatoyannopoulos G (2000). "FKLF-2: a novel Krüppel-like transcriptional factor that activates globin and other erythroid lineage genes.". Blood 95 (11): 3578–84. PMID 10828046.
- Scohy S, Gabant P, Van Reeth T et al. (2001). "Identification of KLF13 and KLF14 (SP6), novel members of the SP/XKLF transcription factor family.". Genomics 70 (1): 93–101. doi:10.1006/geno.2000.6362. PMID 11087666.
- Kaczynski J, Zhang JS, Ellenrieder V et al. (2001). "The Sp1-like protein BTEB3 inhibits transcription via the basic transcription element box by interacting with mSin3A and HDAC-1 co-repressors and competing with Sp1.". J. Biol. Chem. 276 (39): 36749–56. doi:10.1074/jbc.M105831200. PMID 11477107.
- Song CZ, Keller K, Murata K et al. (2002). "Functional interaction between coactivators CBP/p300, PCAF, and transcription factor FKLF2.". J. Biol. Chem. 277 (9): 7029–36. doi:10.1074/jbc.M108826200. PMC 2808425. PMID 11748222.
- Kaczynski JA, Conley AA, Fernandez Zapico M et al. (2002). "Functional analysis of basic transcription element (BTE)-binding protein (BTEB) 3 and BTEB4, a novel Sp1-like protein, reveals a subfamily of transcriptional repressors for the BTE site of the cytochrome P4501A1 gene promoter.". Biochem. J. 366 (Pt 3): 873–82. doi:10.1042/BJ20020388. PMC 1222816. PMID 12036432.
- Song A, Patel A, Thamatrakoln K et al. (2002). "Functional domains and DNA-binding sequences of RFLAT-1/KLF13, a Krüppel-like transcription factor of activated T lymphocytes.". J. Biol. Chem. 277 (33): 30055–65. doi:10.1074/jbc.M204278200. PMID 12050170.
- Nikolcheva T, Pyronnet S, Chou SY et al. (2002). "A translational rheostat for RFLAT-1 regulates RANTES expression in T lymphocytes.". J. Clin. Invest. 110 (1): 119–26. doi:10.1172/JCI15336. PMC 151028. PMID 12093895.
- Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Gerhard DS, Wagner L, Feingold EA et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Mitsuma A, Asano H, Kinoshita T et al. (2005). "Transcriptional regulation of FKLF-2 (KLF13) gene in erythroid cells.". Biochim. Biophys. Acta 1727 (2): 125–33. doi:10.1016/j.bbaexp.2004.12.007. PMC 2808416. PMID 15716005.
- Zhang P, Basu P, Redmond LC et al. (2006). "A functional screen for Krüppel-like factors that regulate the human gamma-globin gene through the CACCC promoter element.". Blood Cells Mol. Dis. 35 (2): 227–35. doi:10.1016/j.bcmd.2005.04.009. PMID 16023392.
- Ahn YT, Huang B, McPherson L et al. (2007). "Dynamic interplay of transcriptional machinery and chromatin regulates "late" expression of the chemokine RANTES in T lymphocytes.". Mol. Cell. Biol. 27 (1): 253–66. doi:10.1128/MCB.01071-06. PMC 1800668. PMID 17074812.
- Huang B, Ahn YT, McPherson L et al. (2007). "Interaction of PRP4 with Kruppel-like factor 13 regulates CCL5 transcription.". J. Immunol. 178 (11): 7081–7. doi:10.4049/jimmunol.178.11.7081. PMC 2674583. PMID 17513757.
External links
- KLF13 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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