Homeobox protein Hox-B13 is a protein that in humans is encoded by the HOXB13gene.[1][2][3]
This gene encodes a transcription factor that belongs to the homeobox gene family. Genes of this family are highly conserved among vertebrates and essential for vertebrate embryonic development. This gene has been implicated in fetal skin development and cutaneous regeneration. In mice, a similar gene was shown to exhibit temporal and spatial colinearity in the main body axis of the embryo, but was not expressed in the secondary axes, which suggests functions in body patterning along the axis. This gene and other HOXB genes form a gene cluster on chromosome 17 in the 17q21-22 region.[3] Men who inherit a rare (<0.1% in a selected group of patients without clinical signs of prostate cancer) genetic variant in HOXB13 (G84E or rs138213197) have a 10-20-fold increased risk of prostate cancer.[4]
^Zeltser L, Desplan C, Heintz N (Sep 1996). "Hoxb-13: a new Hox gene in a distant region of the HOXB cluster maintains colinearity". Development122 (8): 2475–84. PMID8756292.
^Stelnicki EJ, Arbeit J, Cass DL, Saner C, Harrison M, Largman C (Jul 1998). "Modulation of the human homeobox genes PRX-2 and HOXB13 in scarless fetal wounds". J Invest Dermatol111 (1): 57–63. doi:10.1046/j.1523-1747.1998.00238.x. PMID9665387.
^Ewing C et al. (Jan 2012). "Germline mutations in HOXB13 and prostate cancer risk". New Engl J Med366 (2): 141–9. doi:10.1056/NEJMoa1110000. PMID22236224.CS1 maint: Explicit use of et al. (link)
Further reading
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID9373149.CS1 maint: Explicit use of et al. (link)
Kosaki K, Kosaki R, Suzuki T et al. (2002). "Complete mutation analysis panel of the 39 human HOX genes.". Teratology65 (2): 50–62. doi:10.1002/tera.10009. PMID11857506.CS1 maint: Explicit use of et al. (link)
Kömüves LG, Ma XK, Stelnicki E et al. (2004). "HOXB13 homeodomain protein is cytoplasmic throughout fetal skin development.". Dev. Dyn.227 (2): 192–202. doi:10.1002/dvdy.10290. PMID12761847.CS1 maint: Explicit use of et al. (link)
Jung C, Kim RS, Lee SJ et al. (2004). "HOXB13 homeodomain protein suppresses the growth of prostate cancer cells by the negative regulation of T-cell factor 4.". Cancer Res.64 (9): 3046–51. doi:10.1158/0008-5472.CAN-03-2614. PMID15126340.CS1 maint: Explicit use of et al. (link)
Jung C, Kim RS, Zhang HJ et al. (2005). "HOXB13 induces growth suppression of prostate cancer cells as a repressor of hormone-activated androgen receptor signaling.". Cancer Res.64 (24): 9185–92. doi:10.1158/0008-5472.CAN-04-1330. PMID15604291.CS1 maint: Explicit use of et al. (link)
Zhao Y, Yamashita T, Ishikawa M (2005). "Regulation of tumor invasion by HOXB13 gene overexpressed in human endometrial cancer.". Oncol. Rep.13 (4): 721–6. doi:10.3892/or.13.4.721. PMID15756448.
Symmans WF (2006). "Genomic testing for sensitivity of breast cancer to hormonal therapy.". Clin. Cancer Res.12 (7 Pt 1): 1954–5. doi:10.1158/1078-0432.CCR-06-0289. PMID16609001.
Goetz MP, Suman VJ, Ingle JN et al. (2006). "A two-gene expression ratio of homeobox 13 and interleukin-17B receptor for prediction of recurrence and survival in women receiving adjuvant tamoxifen.". Clin. Cancer Res.12 (7 Pt 1): 2080–7. doi:10.1158/1078-0432.CCR-05-1263. PMID16609019.CS1 maint: Explicit use of et al. (link)
Cazal C, Sobral AP, de Almeida FC et al. (2006). "The homeobox HOXB13 is expressed in human minor salivary gland.". Oral diseases12 (4): 424–7. doi:10.1111/j.1601-0825.2005.01218.x. PMID16792730.CS1 maint: Explicit use of et al. (link)
Ma XJ, Hilsenbeck SG, Wang W et al. (2006). "The HOXB13:IL17BR expression index is a prognostic factor in early-stage breast cancer.". J. Clin. Oncol.24 (28): 4611–9. doi:10.1200/JCO.2006.06.6944. PMID17008703.CS1 maint: Explicit use of et al. (link)
Muthusamy V, Duraisamy S, Bradbury CM et al. (2007). "Epigenetic silencing of novel tumor suppressors in malignant melanoma.". Cancer Res.66 (23): 11187–93. doi:10.1158/0008-5472.CAN-06-1274. PMID17145863.CS1 maint: Explicit use of et al. (link)
Ewing C et al. (2012). "Germline mutations in HOXB13 and prostate cancer risk.". New Engl J Med366 (2): 141–9. doi:10.1056/NEJMoa1110000. PMID22236224.CS1 maint: Explicit use of et al. (link)
PDB gallery
2cra: Solution structure of the homeobox domain of human homeo box B13