Zinc finger protein 74 | |||||||||||||
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Identifiers | |||||||||||||
Symbols | ZNF74 ; COS52; ZFP520; ZNF520; hZNF7 | ||||||||||||
External IDs | OMIM: 194548 HomoloGene: 88675 GeneCards: ZNF74 Gene | ||||||||||||
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RNA expression pattern | |||||||||||||
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More reference expression data | |||||||||||||
Orthologs | |||||||||||||
Species | Human | Mouse | |||||||||||
Entrez | 7625 | n/a | |||||||||||
Ensembl | ENSG00000185252 | n/a | |||||||||||
UniProt | Q16587 | n/a | |||||||||||
RefSeq (mRNA) | NM_001256523 | n/a | |||||||||||
RefSeq (protein) | NP_001243452 | n/a | |||||||||||
Location (UCSC) | Chr 22: 20.75 – 20.76 Mb |
n/a | |||||||||||
PubMed search | [1] | n/a | |||||||||||
Zinc finger protein 74 is a protein that in humans is encoded by the ZNF74 gene.[1][2][3] Schizophrenia susceptibility has been associated with a mutation in this protein.[4]
Interactions
ZNF74 has been shown to interact with POLR2A.[5]
References
- ^ Aubry M, Marineau C, Zhang FR, Zahed L, Figlewicz D, Delattre O et al. (August 1992). "Cloning of six new genes with zinc finger motifs mapping to short and long arms of human acrocentric chromosome 22 (p and q11.2)". Genomics 13 (3): 641–8. doi:10.1016/0888-7543(92)90135-F. PMID 1639391.
- ^ Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE et al. (December 1999). "The DNA sequence of human chromosome 22". Nature 402 (6761): 489–95. doi:10.1038/990031. PMID 10591208.
- ^ "Entrez Gene: ZNF74 zinc finger protein 74".
- ^ Takase, K.; T. Ohtsuki; O. Migita; M. Toru; T. Inada; K. Yamakawa-Kobayashi; T. Arinami (1 December 2001). "Association of ZNF74 gene genotypes with age-at-onset of schizophrenia" 52 (3). pp. 161–165.
- ^ Grondin B, Côté F, Bazinet M, Vincent M, Aubry M (October 1997). "Direct interaction of the KRAB/Cys2-His2 zinc finger protein ZNF74 with a hyperphosphorylated form of the RNA polymerase II largest subunit". J. Biol. Chem. 272 (44): 27877–85. doi:10.1074/jbc.272.44.27877. PMID 9346935.
Further reading
- Aubry M, Demczuk S, Desmaze C, Aikem M, Aurias A, Julien JP et al. (1994). "Isolation of a zinc finger gene consistently deleted in DiGeorge syndrome". Hum. Mol. Genet. 2 (10): 1583–7. doi:10.1093/hmg/2.10.1583. PMID 8268910.
- Grondin B, Bazinet M, Aubry M (1996). "The KRAB zinc finger gene ZNF74 encodes an RNA-binding protein tightly associated with the nuclear matrix". J. Biol. Chem. 271 (26): 15458–67. doi:10.1074/jbc.271.26.15458. PMID 8663113.
- Grondin B, Côté F, Bazinet M, Vincent M, Aubry M (1997). "Direct interaction of the KRAB/Cys2-His2 zinc finger protein ZNF74 with a hyperphosphorylated form of the RNA polymerase II largest subunit". J. Biol. Chem. 272 (44): 27877–85. doi:10.1074/jbc.272.44.27877. PMID 9346935.
- Ravassard P, Côté F, Grondin B, Bazinet M, Mallet J, Aubry M (2000). "ZNF74, a gene deleted in DiGeorge syndrome, is expressed in human neural crest-derived tissues and foregut endoderm epithelia". Genomics 62 (1): 82–5. doi:10.1006/geno.1999.5982. PMID 10585771.
- Côté F, Boisvert FM, Grondin B, Bazinet M, Goodyer CG, Bazett-Jones DP et al. (2001). "Alternative promoter usage and splicing of ZNF74 multifinger gene produce protein isoforms with a different repressor activity and nuclear partitioning". DNA Cell Biol. 20 (3): 159–73. doi:10.1089/104454901300069004. PMID 11313019.
- Takase K, Ohtsuki T, Migita O, Toru M, Inada T, Yamakawa-Kobayashi K et al. (2001). "Association of ZNF74 gene genotypes with age-at-onset of schizophrenia". Schizophrenia Research 52 (3): 161–5. doi:10.1016/S0920-9964(00)00191-2. PMID 11705709.
- Germain-Desprez D, Bazinet M, Bouvier M, Aubry M (2003). "Oligomerization of transcriptional intermediary factor 1 regulators and interaction with ZNF74 nuclear matrix protein revealed by bioluminescence resonance energy transfer in living cells". J. Biol. Chem. 278 (25): 22367–73. doi:10.1074/jbc.M302234200. PMID 12684500.
- Collins JE, Wright CL, Edwards CA, Davis MP, Grinham JA, Cole CG et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome". Genome Biol. 5 (10): R84. doi:10.1186/gb-2004-5-10-r84. PMC 545604. PMID 15461802.
- Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
External links
- ZNF74 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
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This article incorporates text from the United States National Library of Medicine, which is in the public domain.