Homeodomain-only protein is a protein that in humans is encoded by the HOPXgene.[1][2]
The protein encoded by this gene is a homeodomain protein that lacks certain conserved residues required for DNA binding. It was reported that choriocarcinoma cell lines and tissues failed to express this gene, which suggested the possible involvement of this gene in malignant conversion of placental trophoblasts. Studies in mice suggested that this protein may interact with serum response factor (SRF) and modulate SRF-dependent cardiac-specific gene expression and cardiac development. Multiple alternatively spliced transcript variants encoding the same protein have been observed, the full-length natures of only some have been determined.[2]
References
^Chen F, Kook H, Milewski R, Gitler AD, Lu MM, Li J, Nazarian R, Schnepp R, Jen K, Biben C, Runke G, Mackay JP, Novotny J, Schwartz RJ, Harvey RP, Mullins MC, Epstein JA (Sep 2002). "Hop is an unusual homeobox gene that modulates cardiac development". Cell110 (6): 713–23. doi:10.1016/S0092-8674(02)00932-7. PMID12297045.
Kook H, Epstein JA (2004). "Hopping to the beat. Hop regulation of cardiac gene expression.". Trends Cardiovasc. Med.13 (7): 261–4. doi:10.1016/S1050-1738(03)00107-5. PMID14522464.
Asanoma K, Matsuda T, Kondo H et al. (2003). "NECC1, a candidate choriocarcinoma suppressor gene that encodes a homeodomain consensus motif.". Genomics81 (1): 15–25. doi:10.1016/S0888-7543(02)00011-3. PMID12573257.CS1 maint: Explicit use of et al. (link)
Chen Y, Petersen S, Pacyna-Gengelbach M et al. (2003). "Identification of a novel homeobox-containing gene, LAGY, which is downregulated in lung cancer.". Oncology64 (4): 450–8. doi:10.1159/000070306. PMID12759545.CS1 maint: Explicit use of et al. (link)
Adu J, Leong FT, Smith NR et al. (2002). "Expression of mOb1, a novel atypical 73 amino acid K50-homeodomain protein, during mouse development.". Mech. Dev. 119. Suppl 1: S43–7. doi:10.1016/S0925-4773(03)00090-X. PMID14516659.CS1 maint: Explicit use of et al. (link)
Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet.36 (1): 40–5. doi:10.1038/ng1285. PMID14702039.CS1 maint: Explicit use of et al. (link)
Pauws E, Sijmons GG, Yaka C, Ris-Stalpers C (2005). "A novel homeobox gene overexpressed in thyroid carcinoma.". Thyroid14 (7): 500–5. doi:10.1089/1050725041517020. PMID15307938.
Toruner GA, Ulger C, Alkan M et al. (2004). "Association between gene expression profile and tumor invasion in oral squamous cell carcinoma.". Cancer Genet. Cytogenet.154 (1): 27–35. doi:10.1016/j.cancergencyto.2004.01.026. PMID15381369.CS1 maint: Explicit use of et al. (link)
Asanoma K, Kato H, Inoue T et al. (2004). "Analysis of a candidate gene associated with growth suppression of choriocarcinoma and differentiation of trophoblasts.". The Journal of reproductive medicine49 (8): 617–26. PMID15457851.CS1 maint: Explicit use of et al. (link)
Kook H, Yung WW, Simpson RJ et al. (2006). "Analysis of the structure and function of the transcriptional coregulator HOP.". Biochemistry45 (35): 10584–90. doi:10.1021/bi060641s. PMID16939210.CS1 maint: Explicit use of et al. (link)
Kee HJ, Kim JR, Nam KI et al. (2007). "Enhancer of polycomb1, a novel homeodomain only protein-binding partner, induces skeletal muscle differentiation.". J. Biol. Chem.282 (10): 7700–9. doi:10.1074/jbc.M611198200. PMID17192267.CS1 maint: Explicit use of et al. (link)
Americo TA, Chiarini LB, Linden R (2007). "Signaling induced by hop/STI-1 depends on endocytosis.". Biochem. Biophys. Res. Commun.358 (2): 620–5. doi:10.1016/j.bbrc.2007.04.202. PMID17498662.
PDB gallery
2hi3: Solution structure of the homeodomain-only protein HOP