Hairy/enhancer-of-split related with YRPW motif protein 1 is a protein that in humans is encoded by the HEY1gene.[1][2][3]
This gene encodes a nuclear protein belonging to the hairy and enhancer of split-related (HESR) family of basic helix-loop-helix (bHLH)-type transcriptional repressors. Expression of this gene is induced by the Notch and c-Jun signal transduction pathways. Two similar and redundant genes in mouse are required for embryonic cardiovascular development, and are also implicated in neurogenesis and somitogenesis. Alternative splicing results in multiple transcript variants.[3]
References
^Leimeister C, Externbrink A, Klamt B, Gessler M (Sep 1999). "Hey genes: a novel subfamily of hairy- and Enhancer of split related genes specifically expressed during mouse embryogenesis". Mech Dev85 (1–2): 173–7. doi:10.1016/S0925-4773(99)00080-5. PMID10415358.
^Kokubo H, Lun Y, Johnson RL (Aug 1999). "Identification and expression of a novel family of bHLH cDNAs related to Drosophila hairy and enhancer of split". Biochem Biophys Res Commun260 (2): 459–65. doi:10.1006/bbrc.1999.0880. PMID10403790.
Iso T, Kedes L, Hamamori Y (2003). "HES and HERP families: multiple effectors of the Notch signaling pathway". J. Cell. Physiol.194 (3): 237–55. doi:10.1002/jcp.10208. PMID12548545.
Kokubo H, Miyagawa-Tomita S, Johnson RL (2006). "Hesr, a mediator of the Notch signaling, functions in heart and vessel development". Trends Cardiovasc. Med.15 (5): 190–4. doi:10.1016/j.tcm.2005.05.005. PMID16165016.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID8125298.
Suzuki Y; Yoshitomo-Nakagawa K; Maruyama K et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID9373149.Cite uses deprecated parameter |author-separator= (help)
Chin MT; Maemura K; Fukumoto S et al. (2000). "Cardiovascular basic helix loop helix factor 1, a novel transcriptional repressor expressed preferentially in the developing and adult cardiovascular system". J. Biol. Chem.275 (9): 6381–7. doi:10.1074/jbc.275.9.6381. PMID10692439.Cite uses deprecated parameter |author-separator= (help)
Steidl C; Leimeister C; Klamt B et al. (2000). "Characterization of the human and mouse HEY1, HEY2, and HEYL genes: cloning, mapping, and mutation screening of a new bHLH gene family". Genomics66 (2): 195–203. doi:10.1006/geno.2000.6200. PMID10860664.Cite uses deprecated parameter |author-separator= (help)
Maier MM, Gessler M (2000). "Comparative analysis of the human and mouse Hey1 promoter: Hey genes are new Notch target genes". Biochem. Biophys. Res. Commun.275 (2): 652–60. doi:10.1006/bbrc.2000.3354. PMID10964718.
Ota T; Suzuki Y; Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet.36 (1): 40–5. doi:10.1038/ng1285. PMID14702039.Cite uses deprecated parameter |author-separator= (help)