Transcriptional enhancer factor TEF-3 is a protein that in humans is encoded by the TEAD4 gene.[1][2][3]
This gene product is a member of the transcriptional enhancer factor (TEF) family of transcription factors, which contain the TEA/ATTS DNA-binding domain. It is preferentially expressed in the skeletal muscle, and binds to the M-CAT regulatory element found in promoters of muscle-specific genes to direct their gene expression. Alternatively spliced transcripts encoding distinct isoforms, some of which are translated through the use of a non-AUG (UUG) initiation codon, have been described for this gene.[3]
References
- ^ Jacquemin P, Depetris D, Mattei MG, Martial JA, Davidson I (Mar 1999). "Localization of human transcription factor TEF-4 and TEF-5 (TEAD2, TEAD3) genes to chromosomes 19q13.3 and 6p21.2 using fluorescence in situ hybridization and radiation hybrid analysis". Genomics 55 (1): 127–9. doi:10.1006/geno.1998.5628. PMID 9889009.
- ^ Stewart AF, Richard CW 3rd, Suzow J, Stephan D, Weremowicz S, Morton CC, Adra CN (Feb 1997). "Cloning of human RTEF-1, a transcriptional enhancer factor-1-related gene preferentially expressed in skeletal muscle: evidence for an ancient multigene family". Genomics 37 (1): 68–76. doi:10.1006/geno.1996.0522. PMID 8921372.
- ^ a b "Entrez Gene: TEAD4 TEA domain family member 4".
Further reading
- Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
- Hsu DK; Guo Y; Alberts GF et al. (1996). "Identification of a murine TEF-1-related gene expressed after mitogenic stimulation of quiescent fibroblasts and during myogenic differentiation". J. Biol. Chem. 271 (23): 13786–95. doi:10.1074/jbc.271.23.13786. PMID 8662936.
- Jacquemin P; Hwang JJ; Martial JA et al. (1996). "A novel family of developmentally regulated mammalian transcription factors containing the TEA/ATTS DNA binding domain". J. Biol. Chem. 271 (36): 21775–85. doi:10.1074/jbc.271.36.21775. PMID 8702974.
- Suzuki Y; Yoshitomo-Nakagawa K; Maruyama K et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- Vaudin P; Delanoue R; Davidson I et al. (1999). "TONDU (TDU), a novel human protein related to the product of vestigial (vg) gene of Drosophila melanogaster interacts with vertebrate TEF factors and substitutes for Vg function in wing formation". Development 126 (21): 4807–16. PMID 10518497.
- Vassilev A; Kaneko KJ; Shu H et al. (2001). "TEAD/TEF transcription factors utilize the activation domain of YAP65, a Src/Yes-associated protein localized in the cytoplasm". Genes Dev. 15 (10): 1229–41. doi:10.1101/gad.888601. PMC 313800. PMID 11358867.
- Strausberg RL; Feingold EA; Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Chen HH; Baty CJ; Maeda T et al. (2005). "Transcription enhancer factor-1-related factor-transgenic mice develop cardiac conduction defects associated with altered connexin phosphorylation". Circulation 110 (19): 2980–7. doi:10.1161/01.CIR.0000146902.84099.26. PMID 15520314.
- Rual JF; Venkatesan K; Hao T et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
- Appukuttan B; McFarland TJ; Davies MH et al. (2007). "Identification of novel alternatively spliced isoforms of RTEF-1 within human ocular vascular endothelial cells and murine retina". Invest. Ophthalmol. Vis. Sci. 48 (8): 3775–82. doi:10.1167/iovs.06-1172. PMID 17652751.
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External links
- TEAD4 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
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