The retinoid X receptor (RXR )[ 1] is a type of nuclear receptor that is activated by 9-cis retinoic acid .[ 2] There are three retinoic X receptors (RXR): RXR-alpha , RXR-beta , and RXR-gamma , encoded by the RXRA , RXRB , RXRG genes, respectively.
RXR heterodimerizes with subfamily 1 nuclear receptors including CAR , FXR , LXR , PPAR ,[ 3] PXR , RAR , TR , and VDR .
As with other type II nuclear receptors, the RXR heterodimer in the absence of ligand is bound to hormone response elements complexed with corepressor protein. Binding of agonist ligands to RXR results in dissociation of corepressor and recruitment of coactivator protein, which, in turn, promotes transcription of the downstream target gene into mRNA and eventually protein .
See also
References
^ Germain P, Chambon P, Eichele G, Evans RM, Lazar MA, Leid M, De Lera AR, Lotan R, Mangelsdorf DJ, Gronemeyer H (2006). "International Union of Pharmacology. LXIII. Retinoid X receptors". Pharmacol Rev 58 (4): 760–72. doi :10.1124/pr.58.4.7 . PMID 17132853 .
^ Allenby G, Bocquel MT, Saunders M, Kazmer S, Speck J, Rosenberger M, Lovey A, Kastner P, Grippo JF, Chambon P, Levin AA (1993). "Retinoic acid receptors and retinoid X receptors: interactions with endogenous retinoic acids" . Proc Natl Acad Sci USA 90 (1): 30–4. doi :10.1073/pnas.90.1.30 . PMC 45593 . PMID 8380496 .
^ Plutzky J (April 2011). "The PPAR-RXR transcriptional complex in the vasculature: energy in the balance". Circ. Res. 108 (8): 1002–16. doi :10.1161/CIRCRESAHA.110.226860 . PMID 21493923 .
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(2.1) Nuclear receptor (Cys4 )
subfamily 1
subfamily 2
subfamily 3
subfamily 4
subfamily 5
subfamily 6
subfamily 0
(2.2) Other Cys4
(2.3) Cys2 His2
(2.4) Cys6
(2.5) Alternating composition
(2.6) WRKY
(4) β-Scaffold factors with minor groove contacts
(0) Other transcription factors
Index of genetics
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Disease