Transcription factor GATA-5 is a protein that in humans is encoded by the GATA5 gene.[1][2]
The protein encoded by this gene is a transcription factor that contains two GATA-type zinc fingers. The encoded protein is known to bind to hepatocyte nuclear factor-1alpha (HNF-1alpha), and this interaction is essential for cooperative activation of the intestinal lactase-phlorizin hydrolase promoter. In other organisms, similar proteins may be involved in the establishment of cardiac smooth muscle cell diversity.[2]
See also
References
- ^ Gao X, Sedgwick T, Shi YB, Evans T (May 1998). "Distinct functions are implicated for the GATA-4, -5, and -6 transcription factors in the regulation of intestine epithelial cell differentiation". Mol Cell Biol 18 (5): 2901–11. PMC 110669. PMID 9566909.
- ^ a b "Entrez Gene: GATA5 GATA binding protein 5".
Further reading
- Kakita T, Hasegawa K, Morimoto T et al. (1999). "p300 protein as a coactivator of GATA-5 in the transcription of cardiac-restricted atrial natriuretic factor gene.". J. Biol. Chem. 274 (48): 34096–102. doi:10.1074/jbc.274.48.34096. PMID 10567378.
- Krasinski SD, Van Wering HM, Tannemaat MR, Grand RJ (2001). "Differential activation of intestinal gene promoters: functional interactions between GATA-5 and HNF-1 alpha.". Am. J. Physiol. Gastrointest. Liver Physiol. 281 (1): G69–84. PMID 11408257.
- Deloukas P, Matthews LH, Ashurst J et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20.". Nature 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052.
- van Wering HM, Huibregtse IL, van der Zwan SM et al. (2002). "Physical interaction between GATA-5 and hepatocyte nuclear factor-1alpha results in synergistic activation of the human lactase-phlorizin hydrolase promoter.". J. Biol. Chem. 277 (31): 27659–67. doi:10.1074/jbc.M203645200. PMID 12011060.
- Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Benchabane H, Wrana JL (2003). "GATA- and Smad1-dependent enhancers in the Smad7 gene differentially interpret bone morphogenetic protein concentrations.". Mol. Cell. Biol. 23 (18): 6646–61. doi:10.1128/MCB.23.18.6646-6661.2003. PMC 193708. PMID 12944489.
- Akiyama Y, Watkins N, Suzuki H et al. (2003). "GATA-4 and GATA-5 transcription factor genes and potential downstream antitumor target genes are epigenetically silenced in colorectal and gastric cancer.". Mol. Cell. Biol. 23 (23): 8429–39. doi:10.1128/MCB.23.23.8429-8439.2003. PMC 262684. PMID 14612389.
- Divine JK, Staloch LJ, Haveri H et al. (2004). "GATA-4, GATA-5, and GATA-6 activate the rat liver fatty acid binding protein gene in concert with HNF-1alpha.". Am. J. Physiol. Gastrointest. Liver Physiol. 287 (5): G1086–99. doi:10.1152/ajpgi.00421.2003. PMID 14715527.
- Gerhard DS, Wagner L, Feingold EA et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Guo M, Akiyama Y, House MG et al. (2005). "Hypermethylation of the GATA genes in lung cancer.". Clin. Cancer Res. 10 (23): 7917–24. doi:10.1158/1078-0432.CCR-04-1140. PMID 15585625.
- Wakana K, Akiyama Y, Aso T, Yuasa Y (2006). "Involvement of GATA-4/-5 transcription factors in ovarian carcinogenesis.". Cancer Lett. 241 (2): 281–8. doi:10.1016/j.canlet.2005.10.039. PMID 16337738.
- Guo M, House MG, Akiyama Y et al. (2006). "Hypermethylation of the GATA gene family in esophageal cancer.". Int. J. Cancer 119 (9): 2078–83. doi:10.1002/ijc.22092. PMID 16823849.
External links
- GATA5 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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