Homeobox protein Hox-B5 is a protein that in humans is encoded by the HOXB5gene.[1][2][3]
This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in lung and gut development. Increased expression of this gene is associated with a distinct biologic subset of acute myeloid leukemia (AML) and the occurrence of bronchopulmonary sequestration (BPS) and congenital cystic adenomatoid malformation (CCAM) tissue.[3]
Galang CK, Hauser CA (1992). "Cooperative DNA binding of the highly conserved human Hox 2.1 homeodomain gene product.". New Biol.4 (5): 558–68. PMID1355360.
Peverali FA, D'Esposito M, Acampora D et al. (1991). "Expression of HOX homeogenes in human neuroblastoma cell culture lines.". Differentiation45 (1): 61–9. doi:10.1111/j.1432-0436.1990.tb00458.x. PMID1981366.CS1 maint: Explicit use of et al. (link)
Giampaolo A, Acampora D, Zappavigna V et al. (1989). "Differential expression of human HOX-2 genes along the anterior-posterior axis in embryonic central nervous system.". Differentiation40 (3): 191–7. doi:10.1111/j.1432-0436.1989.tb00598.x. PMID2570724.CS1 maint: Explicit use of et al. (link)
Boncinelli E, Acampora D, Pannese M et al. (1990). "Organization of human class I homeobox genes.". Genome31 (2): 745–56. doi:10.1139/g89-133. PMID2576652.CS1 maint: Explicit use of et al. (link)
Hart CP, Awgulewitsch A, Fainsod A et al. (1986). "Homeo box gene complex on mouse chromosome 11: molecular cloning, expression in embryogenesis, and homology to a human homeo box locus.". Cell43 (1): 9–18. doi:10.1016/0092-8674(85)90007-8. PMID3000607.CS1 maint: Explicit use of et al. (link)
Simeone A, Mavilio F, Bottero L et al. (1986). "A human homoeo box gene specifically expressed in spinal cord during embryonic development.". Nature320 (6064): 763–5. doi:10.1038/320763a0. PMID3453105.CS1 maint: Explicit use of et al. (link)
Hauser CA, Joyner AL, Klein RD et al. (1986). "Expression of homologous homeo-box-containing genes in differentiated human teratocarcinoma cells and mouse embryos.". Cell43 (1): 19–28. doi:10.1016/0092-8674(85)90008-X. PMID4075393.CS1 maint: Explicit use of et al. (link)
Levine M, Rubin GM, Tjian R (1984). "Human DNA sequences homologous to a protein coding region conserved between homeotic genes of Drosophila.". Cell38 (3): 667–73. doi:10.1016/0092-8674(84)90261-7. PMID6091895.
Apiou F, Flagiello D, Cillo C et al. (1996). "Fine mapping of human HOX gene clusters.". Cytogenet. Cell Genet.73 (1-2): 114–5. doi:10.1159/000134320. PMID8646877.CS1 maint: Explicit use of et al. (link)
Kuliev A, Kukharenko V, Morozov G et al. (1996). "Expression of homebox-containing genes in human preimplantation development and in embryos with chromosomal aneuploidies.". J. Assist. Reprod. Genet.13 (2): 177–81. doi:10.1007/BF02072541. PMID8688592.CS1 maint: Explicit use of et al. (link)
Sakach M, Safaei R (1997). "Localization of the HoxB5 protein in the developing CNS of late gestational mouse embryos.". Int. J. Dev. Neurosci.14 (5): 567–73. doi:10.1016/0736-5748(96)00052-4. PMID8930688.
Archavachotikul K, Ciccone TJ, Chinoy MR et al. (2002). "Thyroid hormone affects embryonic mouse lung branching morphogenesis and cellular differentiation.". Am. J. Physiol. Lung Cell Mol. Physiol.282 (3): L359–69. doi:10.1203/00006450-199904020-00286. PMID11839528.CS1 maint: Explicit use of et al. (link)
Kosaki K, Kosaki R, Suzuki T et al. (2002). "Complete mutation analysis panel of the 39 human HOX genes.". Teratology65 (2): 50–62. doi:10.1002/tera.10009. PMID11857506.CS1 maint: Explicit use of et al. (link)
1hom: DETERMINATION OF THE THREE-DIMENSIONAL STRUCTURE OF THE ANTENNAPEDIA HOMEODOMAIN FROM DROSOPHILA IN SOLUTION BY 1H NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY
1san: THE DES(1-6)ANTENNAPEDIA HOMEODOMAIN: COMPARISON OF THE NMR SOLUTION STRUCTURE AND THE DNA BINDING AFFINITY WITH THE INTACT ANTENNAPEDIA HOMEODOMAIN