Inhibitor of growth protein 2 is a protein that in humans is encoded by the ING2gene.[1][2]
This gene is a member of the inhibitor of growth (ING) family. Members of the ING family associate with and modulate the activity of histone acetyltransferase (HAT) and histone deacetylase (HDAC) complexes and function in DNA repair and apoptosis.[2]
References
^Shimada Y, Saito A, Suzuki M, Takahashi E, Horie M (Mar 1999). "Cloning of a novel gene (ING1L) homologous to ING1, a candidate tumor suppressor". Cytogenet Cell Genet83 (3–4): 232–5. doi:10.1159/000015188. PMID10072587.
Gozani O; Karuman P; Jones DR et al. (2003). "The PHD finger of the chromatin-associated protein ING2 functions as a nuclear phosphoinositide receptor". Cell114 (1): 99–111. doi:10.1016/S0092-8674(03)00480-X. PMID12859901.Cite uses deprecated parameter |author-separator= (help)
Sironi E; Cerri A; Tomasini D et al. (2004). "Loss of heterozygosity on chromosome 4q32-35 in sporadic basal cell carcinomas: evidence for the involvement of p33ING2/ING1L and SAP30 genes". J. Cutan. Pathol.31 (4): 318–22. doi:10.1111/j.0303-6987.2004.0187.x. PMID15005689.Cite uses deprecated parameter |author-separator= (help)
He GH; Helbing CC; Wagner MJ et al. (2005). "Phylogenetic analysis of the ING family of PHD finger proteins". Mol. Biol. Evol.22 (1): 104–16. doi:10.1093/molbev/msh256. PMID15356280.Cite uses deprecated parameter |author-separator= (help)
Chin MY, Ng KC, Li G (2005). "The novel tumor suppressor p33ING2 enhances UVB-induced apoptosis in human melanoma cells". Exp. Cell Res.304 (2): 531–43. doi:10.1016/j.yexcr.2004.11.023. PMID15748897.
Barrios-Rodiles M; Brown KR; Ozdamar B et al. (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells". Science307 (5715): 1621–5. doi:10.1126/science.1105776. PMID15761153.Cite uses deprecated parameter |author-separator= (help)
Okano T; Gemma A; Hosoya Y et al. (2006). "Alterations in novel candidate tumor suppressor genes, ING1 and ING2 in human lung cancer". Oncol. Rep.15 (3): 545–9. doi:10.3892/or.15.3.545. PMID16465410.Cite uses deprecated parameter |author-separator= (help)
Wang J, Chin MY, Li G (2006). "The novel tumor suppressor p33ING2 enhances nucleotide excision repair via inducement of histone H4 acetylation and chromatin relaxation". Cancer Res.66 (4): 1906–11. doi:10.1158/0008-5472.CAN-05-3444. PMID16488987.
Wang Y, Wang J, Li G (2006). "Leucine zipper-like domain is required for tumor suppressor ING2-mediated nucleotide excision repair and apoptosis". FEBS Lett.580 (16): 3787–93. doi:10.1016/j.febslet.2006.05.065. PMID16782091.