Myogenic factor 5 is a protein that in humans is encoded by the MYF5 gene. [1] It is a protein with a key role in regulating muscle differentiation or myogenesis. Without Myf5 and MyoD, myogenic cells will fail to progress normally during the determination stage of myogenesis due to underscoring of the dynamics between cell populations and MRF regulation.
Myf5 belongs to a family of proteins known as myogenic regulatory factors (MRFs). These bHLH (basic helix loop helix) transcription factors act sequentially in myogenic differentiation. MRF family members include Myf5, MyoD (Myf3), myogenin, and MRF4 (Myf6).[2]
References
- ^ "Entrez Gene: Myogenic factor 5". Retrieved 2013-08-19.
- ^ Sabourin LA, Rudnicki MA (2000). "The molecular regulation of myogenesis". Clin. Genet. 57 (1): 16–25. doi:10.1034/j.1399-0004.2000.570103.x. PMID 10733231.
Further reading
- Krauss, R. S.; Cole, F.; Gaio, U.; Takaesu, G.; Zhang, W.; Kang, J. S. (2005). "Close encounters: Regulation of vertebrate skeletal myogenesis by cell-cell contact". Journal of Cell Science 118 (11): 2355–2362. doi:10.1242/jcs.02397. PMID 15923648.
- Summerbell, D.; Halai, C.; Rigby, P. W. (2002). "Expression of the myogenic regulatory factor Mrf4 precedes or is contemporaneous with that of Myf5 in the somitic bud". Mechanisms of development 117 (1–2): 331–335. doi:10.1016/S0925-4773(02)00208-3. PMID 12204280.
- Langlands, K.; Yin, X.; Anand, G.; Prochownik, E. V. (1997). "Differential interactions of Id proteins with basic-helix-loop-helix transcription factors". The Journal of biological chemistry 272 (32): 19785–19793. doi:10.1074/jbc.272.32.19785. PMID 9242638.
- Dimicoli-Salazar, S.; Bulle, F.; Yacia, A.; Massé, J. M.; Fichelson, S.; Vigon, I. (2011). "Efficient in vitro myogenic reprogramming of human primary mesenchymal stem cells and endothelial cells by Myf5". Biology of the Cell 103 (11): 531–542. doi:10.1042/BC20100112. PMID 21810080.
- Cupelli, L.; Renault, B.; Leblanc-Straceski, J.; Banks, A.; Ward, D.; Kucherlapati, R. S.; Krauter, K. (1996). "Assignment of the human myogenic factors 5 and 6 (MYF5, MYF6) gene cluster to 12q21 by in situ hybridization and physical mapping of the locus between D12S350 and D12S106". Cytogenetics and cell genetics 72 (2–3): 250–251. doi:10.1159/000134201. PMID 8978788.
- Ansseau, E. N.; Laoudj-Chenivesse, D.; Marcowycz, A.; Tassin, A.; Vanderplanck, C. L.; Sauvage, S. B.; Barro, M.; Mahieu, I.; Leroy, A.; Leclercq, I.; Mainfroid, V. R.; Figlewicz, D.; Mouly, V.; Butler-Browne, G.; Belayew, A.; Coppée, F. D. R. (2009). Callaerts, Patrick, ed. "DUX4c is Up-Regulated in FSHD. It Induces the MYF5 Protein and Human Myoblast Proliferation". PLoS ONE 4 (10): e7482. doi:10.1371/journal.pone.0007482. PMC 2759506. PMID 19829708.
- Winter, B.; Kautzner, I.; Issinger, O. G.; Arnold, H. H. (1997). "Two putative protein kinase CK2 phosphorylation sites are important for Myf-5 activity". Biological chemistry 378 (12): 1445–1456. doi:10.1515/bchm.1997.378.12.1445. PMID 9461343.
- Chen, C. M.; Kraut, N.; Groudine, M.; Weintraub, H. (1996). "I-mf, a novel myogenic repressor, interacts with members of the MyoD family". Cell 86 (5): 731–741. doi:10.1016/S0092-8674(00)80148-8. PMID 8797820.
- Braun, T.; Buschhausen-Denker, G.; Bober, E.; Tannich, E.; Arnold, H. H. (1989). "A novel human muscle factor related to but distinct from MyoD1 induces myogenic conversion in 10T1/2 fibroblasts". The EMBO journal 8 (3): 701–709. PMC 400865. PMID 2721498.
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