CD3e molecule, epsilon also known as CD3E is a polypeptide which in humans is encoded by the CD3E gene which resides on chromosome 11.[1][2]
Contents
Function
The protein encoded by this gene is the CD3-epsilon polypeptide, which together with CD3-gamma, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development.[3]
Clinical significance
Defects in this gene cause severe immunodeficiency.[4][5] This gene has also been linked to a susceptibility to type I diabetes in women.[6]
Interactions
T-cell surface glycoprotein CD3 epsilon chain has been shown to interact with TOP2B,[7] CD3EAP[8] and NCK2.[9]
See also
References
- ^ Gold DP, Puck JM, Pettey CL, Cho M, Coligan J, Woody JN, Terhorst C (1986). "Isolation of cDNA clones encoding the 20K non-glycosylated polypeptide chain of the human T-cell receptor/T3 complex". Nature 321 (6068): 431–4. doi:10.1038/321431a0. PMID 3012357.
- ^ Clevers HC, Dunlap S, Wileman TE, Terhorst C (November 1988). "Human CD3-epsilon gene contains three miniexons and is transcribed from a non-TATA promoter". Proc. Natl. Acad. Sci. U.S.A. 85 (21): 8156–60. doi:10.1073/pnas.85.21.8156. PMC 282386. PMID 3267235.
- ^ "Entrez Gene: CD3E CD3e molecule, epsilon (CD3-TCR complex)".
- ^ Soudais C, de Villartay JP, Le Deist F, Fischer A, Lisowska-Grospierre B (January 1993). "Independent mutations of the human CD3-epsilon gene resulting in a T cell receptor/CD3 complex immunodeficiency". Nat. Genet. 3 (1): 77–81. doi:10.1038/ng0193-77. PMID 8490660.
- ^ de Saint Basile G, Geissmann F, Flori E, Uring-Lambert B, Soudais C, Cavazzana-Calvo M, Durandy A, Jabado N, Fischer A, Le Deist F (November 2004). "Severe combined immunodeficiency caused by deficiency in either the delta or the epsilon subunit of CD3". J. Clin. Invest. 114 (10): 1512–7. doi:10.1172/JCI22588. PMC 525745. PMID 15546002.
- ^ Wong S, Moore S, Orisio S, Millward A, Demaine AG (January 1991). "Susceptibility to type I diabetes in women is associated with the CD3 epsilon locus on chromosome 11". Clin. Exp. Immunol. 83 (1): 69–73. doi:10.1111/j.1365-2249.1991.tb05590.x. PMC 1535466. PMID 1671006.
- ^ Nakano, H; Yamazaki T; Miyatake S; Nozaki N; Kikuchi A; Saito T (Mar 1996). "Specific interaction of topoisomerase II beta and the CD3 epsilon chain of the T cell receptor complex". J. Biol. Chem. (UNITED STATES) 271 (11): 6483–9. doi:10.1074/jbc.271.11.6483. ISSN 0021-9258. PMID 8626450.
- ^ Yamazaki, T; Hamano Y; Tashiro H; Itoh K; Nakano H; Miyatake S; Saito T (Jun 1999). "CAST, a novel CD3epsilon-binding protein transducing activation signal for interleukin-2 production in T cells". J. Biol. Chem. (UNITED STATES) 274 (26): 18173–80. doi:10.1074/jbc.274.26.18173. ISSN 0021-9258. PMID 10373416.
- ^ Gil, Diana; Schamel Wolfgang W A, Montoya María, Sánchez-Madrid Francisco, Alarcón Balbino (Jun 2002). "Recruitment of Nck by CD3 epsilon reveals a ligand-induced conformational change essential for T cell receptor signaling and synapse formation". Cell (United States) 109 (7): 901–12. doi:10.1016/S0092-8674(02)00799-7. ISSN 0092-8674. PMID 12110186.
Further reading
- Li CJ (2007). "Therapeutic biology: checkpoint pathway activation therapy, HIV Tat, and transkingdom RNA interference.". J. Cell. Physiol. 209 (3): 695–700. doi:10.1002/jcp.20817. PMID 17001685.
- Thoenes G, Soudais C, le Deist F et al. (1992). "Structural analysis of low TCR-CD3 complex expression in T cells of an immunodeficient patient.". J. Biol. Chem. 267 (1): 487–93. PMID 1370449.
- Luzzati AL, Giacomini E, Giordani L et al. (1992). "The antigen-specific induction of normal human lymphocytes in vitro is down-regulated by a conserved HIV p24 epitope.". Immunol. Lett. 33 (3): 307–14. doi:10.1016/0165-2478(92)90078-3. PMID 1385321.
- Lanier LL, Chang C, Spits H, Phillips JH (1992). "Expression of cytoplasmic CD3 epsilon proteins in activated human adult natural killer (NK) cells and CD3 gamma, delta, epsilon complexes in fetal NK cells. Implications for the relationship of NK and T lymphocytes.". J. Immunol. 149 (6): 1876–80. PMID 1387664.
- Wong S, Moore S, Orisio S et al. (1991). "Susceptibility to type I diabetes in women is associated with the CD3 epsilon locus on chromosome 11.". Clin. Exp. Immunol. 83 (1): 69–73. doi:10.1111/j.1365-2249.1991.tb05590.x. PMC 1535466. PMID 1671006.
- Ruegg CL, Strand M (1991). "A synthetic peptide with sequence identity to the transmembrane protein GP41 of HIV-1 inhibits distinct lymphocyte activation pathways dependent on protein kinase C and intracellular calcium influx.". Cell. Immunol. 137 (1): 1–13. doi:10.1016/0008-8749(91)90051-C. PMID 1832084.
- Cefai D, Debre P, Kaczorek M et al. (1991). "Human immunodeficiency virus-1 glycoproteins gp120 and gp160 specifically inhibit the CD3/T cell-antigen receptor phosphoinositide transduction pathway.". J. Clin. Invest. 86 (6): 2117–24. doi:10.1172/JCI114950. PMC 329852. PMID 1979339.
- Luzzati AL, Pugliese O, Giacomini E et al. (1990). "Immunoregulatory effect of a synthetic peptide corresponding to a region of protein p24 of HIV.". Folia Biol. (Praha) 36 (1): 71–7. PMID 2111780.
- Koning F, Maloy WL, Coligan JE (1990). "The implications of subunit interactions for the structure of the T cell receptor-CD3 complex.". Eur. J. Immunol. 20 (2): 299–305. doi:10.1002/eji.1830200211. PMID 2138083.
- van den Elsen P, Shepley BA, Cho M, Terhorst C (1985). "Isolation and characterization of a cDNA clone encoding the murine homologue of the human 20K T3/T-cell receptor glycoprotein.". Nature 314 (6011): 542–4. doi:10.1038/314542a0. PMID 2859526.
- Gold DP, Puck JM, Pettey CL et al. (1986). "Isolation of cDNA clones encoding the 20K non-glycosylated polypeptide chain of the human T-cell receptor/T3 complex.". Nature 321 (6068): 431–4. doi:10.1038/321431a0. PMID 3012357.
- Clevers HC, Dunlap S, Wileman TE, Terhorst C (1988). "Human CD3-epsilon gene contains three miniexons and is transcribed from a non-TATA promoter.". Proc. Natl. Acad. Sci. U.S.A. 85 (21): 8156–60. doi:10.1073/pnas.85.21.8156. PMC 282386. PMID 3267235.
- Gold DP, Clevers H, Alarcon B et al. (1987). "Evolutionary relationship between the T3 chains of the T-cell receptor complex and the immunoglobulin supergene family.". Proc. Natl. Acad. Sci. U.S.A. 84 (21): 7649–53. doi:10.1073/pnas.84.21.7649. PMC 299357. PMID 3478717.
- DeNofrio D, Radcliff G, Weinhold KJ, Denning SM (1996). "CD3 delta and epsilon gene expression in CD3-CD16+ natural killer cell clones derived from thymic precursors.". Hum. Immunol. 43 (4): 283–94. doi:10.1016/0198-8859(95)91034-U. PMID 7499176.
- Kishimoto H, Kubo RT, Yorifuji H et al. (1996). "Physical dissociation of the TCR-CD3 complex accompanies receptor ligation.". J. Exp. Med. 182 (6): 1997–2006. doi:10.1084/jem.182.6.1997. PMC 2192252. PMID 7500045.
- Oravecz T, Norcross MA (1994). "Costimulatory properties of the human CD4 molecule: enhancement of CD3-induced T cell activation by human immunodeficiency virus type 1 through viral envelope glycoprotein gp120.". AIDS Res. Hum. Retroviruses 9 (10): 945–55. doi:10.1089/aid.1993.9.945. PMID 7506554.
- Beecher MS, Baiocchi RA, Linett ML et al. (1994). "Expression of the zeta protein subunit in CD3- NK effectors derived from human thymus.". Cell. Immunol. 155 (2): 508–16. doi:10.1006/cimm.1994.1143. PMID 7514106.
- Luzzati AL, Giacomini E, Giordani L et al. (1994). "An HIV p24 heptapeptide down-regulates antigen-specific responses in vitro interfering at the level of the T3-Ti complex.". Cell. Immunol. 156 (2): 286–95. doi:10.1006/cimm.1994.1175. PMID 7517794.
- Dianzani U, Bragardo M, Buonfiglio D et al. (1995). "Modulation of CD4 lateral interaction with lymphocyte surface molecules induced by HIV-1 gp120.". Eur. J. Immunol. 25 (5): 1306–11. doi:10.1002/eji.1830250526. PMID 7539755.
- Müller B, Cooper L, Terhorst C (1995). "Interplay between the human TCR/CD3 epsilon and the B-cell antigen receptor associated Ig-beta (B29).". Immunol. Lett. 44 (2-3): 97–103. doi:10.1016/0165-2478(94)00199-2. PMID 7541024.
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This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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