T-cell surface glycoprotein CD1e, membrane-associated is a protein that in humans is encoded by the CD1Egene.[1][2]
This gene encodes a member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by this gene localizes within Golgi compartments, endosomes, and lysosomes, and is cleaved into a stable soluble form. The soluble form is required for the intracellular processing of some glycolipids into a form that can be presented by other CD1 family members. Several alternatively spliced transcript variants encoding different isoforms have been described. Additional transcript variants have been found; however, their biological validity has not been determined.[2]
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Angénieux C, Salamero J, Fricker D et al. (2003). "Common characteristics of the human and rhesus macaque CD1e molecules: conservation of biochemical and biological properties during primate evolution.". Immunogenetics54 (12): 842–9. doi:10.1007/s00251-003-0538-0. PMID12671734.
Angénieux C, Fraisier V, Maître B et al. (2005). "The cellular pathway of CD1e in immature and maturing dendritic cells.". Traffic6 (4): 286–302. doi:10.1111/j.1600-0854.2005.00272.x. PMID15752135.
de la Salle H, Mariotti S, Angenieux C et al. (2005). "Assistance of microbial glycolipid antigen processing by CD1e.". Science310 (5752): 1321–4. doi:10.1126/science.1115301. PMID16311334.
Caporale CM, Papola F, Fioroni MA et al. (2006). "Susceptibility to Guillain-Barré syndrome is associated to polymorphisms of CD1 genes.". J. Neuroimmunol.177 (1-2): 112–8. doi:10.1016/j.jneuroim.2006.05.018. PMID16820217.