Cluster of Differentiation 80 (also CD80 and B7-1) is a protein found on activated B cells and monocytes that provides a costimulatory signal necessary for T cell activation and survival. It is the ligand for two different proteins on the T cell surface: CD28 (for autoregulation and intercellular association) and CTLA-4[1][2] (for attenuation of regulation and cellular disassociation). CD80 works in tandem with CD86 to prime T cells.
^Peach, R J; Bajorath J; Naemura J; Leytze G; Greene J; Aruffo A; Linsley P S (Sep 1995). "Both extracellular immunoglobin-like domains of CD80 contain residues critical for binding T cell surface receptors CTLA-4 and CD28". J. Biol. Chem. (UNITED STATES) 270 (36): 21181–7. doi:10.1074/jbc.270.36.21181. ISSN0021-9258. PMID7545666.
^Stamper, C C; Zhang Y; Tobin J F; Erbe D V; Ikemizu S; Davis S J; Stahl M L; Seehra J; Somers W S; Mosyak L (Mar 2001). "Crystal structure of the B7-1/CTLA-4 complex that inhibits human immune responses". Nature (England) 410 (6828): 608–11. doi:10.1038/35069118. ISSN0028-0836. PMID11279502.
Further reading
Weitzmann MN, Pacifici R (2006). "Estrogen regulation of immune cell bone interactions". Ann. N. Y. Acad. Sci.1068: 256–74. doi:10.1196/annals.1346.030. PMID16831927.
Chang TT, Kuchroo VK, Sharpe AH (2002). "Role of the B7-CD28/CTLA-4 pathway in autoimmune disease". Curr. Dir. Autoimmun. Current Directions in Autoimmunity 5: 113–30. doi:10.1159/000060550. ISBN 3-8055-7308-1. PMID11826754.
Quaranta MG, Mattioli B, Giordani L, Viora M (2006). "The immunoregulatory effects of HIV-1 Nef on dendritic cells and the pathogenesis of AIDS". FASEB J.20 (13): 2198–208. doi:10.1096/fj.06-6260rev. PMID17077296.
Freeman GJ, Disteche CM, Gribben JG et al. (1992). "The gene for B7, a costimulatory signal for T-cell activation, maps to chromosomal region 3q13.3-3q21". Blood79 (2): 489–94. PMID1370389.
Selvakumar A, Mohanraj BK, Eddy RL et al. (1992). "Genomic organization and chromosomal location of the human gene encoding the B-lymphocyte activation antigen B7". Immunogenetics36 (3): 175–81. doi:10.1007/BF00661094. PMID1377173.
Freeman GJ, Freedman AS, Segil JM et al. (1989). "B7, a new member of the Ig superfamily with unique expression on activated and neoplastic B cells". J. Immunol.143 (8): 2714–22. PMID2794510.
Weiskirchen R, Pino JD, Macalma T et al. (1996). "The cysteine-rich protein family of highly related LIM domain proteins". J. Biol. Chem.270 (48): 28946–54. doi:10.1074/jbc.270.48.28946. PMID7499425.
Lanier LL, O'Fallon S, Somoza C et al. (1995). "CD80 (B7) and CD86 (B70) provide similar costimulatory signals for T cell proliferation, cytokine production, and generation of CTL". J. Immunol.154 (1): 97–105. PMID7527824.
Chirmule N, McCloskey TW, Hu R et al. (1995). "HIV gp120 inhibits T cell activation by interfering with expression of costimulatory molecules CD40 ligand and CD80 (B71)". J. Immunol.155 (2): 917–24. PMID7541827.
Peach RJ, Bajorath J, Naemura J et al. (1995). "Both extracellular immunoglobin-like domains of CD80 contain residues critical for binding T cell surface receptors CTLA-4 and CD28". J. Biol. Chem.270 (36): 21181–7. doi:10.1074/jbc.270.36.21181. PMID7545666.
Tuosto L, Piazza C, Moretti S et al. (1995). "Ligation of either CD2 or CD28 rescues CD4+ T cells from HIV-gp120-induced apoptosis". Eur. J. Immunol.25 (10): 2917–22. doi:10.1002/eji.1830251031. PMID7589092.
Weiskirchen R, Bister K (1993). "Suppression in transformed avian fibroblasts of a gene (crp) encoding a cysteine-rich protein containing LIM domains". Oncogene8 (9): 2317–24. PMID8361751.
Dono M, Zupo S, Augliera A et al. (1996). "Subepithelial B cells in the human palatine tonsil. II. Functional characterization". Eur. J. Immunol.26 (9): 2043–9. doi:10.1002/eji.1830260912. PMID8814244.
Reeves RH, Patch D, Sharpe AH et al. (1997). "The costimulatory genes Cd80 and Cd86 are linked on mouse chromosome 16 and human chromosome 3". Mamm. Genome8 (8): 581–2. doi:10.1007/s003359900508. PMID9250865.
Olivares EG, Montes MJ, Oliver C et al. (1997). "Cultured human decidual stromal cells express B7-1 (CD80) and B7-2 (CD86) and stimulate allogeneic T cells". Biol. Reprod.57 (3): 609–15. doi:10.1095/biolreprod57.3.609. PMID9282998.
Weiskirchen R, Erdel M, Utermann G, Bister K (1997). "Cloning, structural analysis, and chromosomal localization of the human CSRP2 gene encoding the LIM domain protein CRP2". Genomics44 (1): 83–93. doi:10.1006/geno.1997.4855. PMID9286703.
PDB gallery
1dr9: CRYSTAL STRUCTURE OF A SOLUBLE FORM OF B7-1 (CD80)