ITS, its or it's may refer to:
- It's, an English contraction of it is or it has
- Its, the possessive form of the pronoun it
Computing
- Incompatible Timesharing System, a computer operating system
- Intelligent tutoring system, an artificial intelligence system used for tutoring
- Internationalization Tag Set, a W3C recommendation for internationalizing XML
- Issue tracking system, computer software that manages product issues
- Inter-Plan Teleprocessing System, a processing systems used by Blue Cross and Blue Shield Plans to facilitate co-ordination of health insurance when a patient is outside his or her home state.
Entertainment
- "It's" man, a man with torn clothes and unkempt beard who appeared at the beginning of episodes of Monty Python's Flying Circus
- Improvisational Tribal Style, a subgenre of Tribal Style belly dance
- It's (album), an album by Teen Top
Organizations
- Identity, Tradition, Sovereignty, a former political grouping in the European Parliament
- Indian Telecommunication Service, an organised civil service of Government of India
- Indian Trade Service
- International Thespian Society, an honorary organization for high school and middle school theatre students
- International Tracing Service
- International trade secretariat
- Irish Texts Society, promoting the study of literature
- Irish Thoracic Society
- Islamic Texts Society, an educational charity based in Cambridge, UK
- Islamic Thinkers Society
- International Transportation Service, an American container terminal company
Education
- Institute for Transport Studies, University of Leeds, often abbreviated to ITS Leeds
- Institute of Technology, Sligo, Ireland
- Institut Teknologi Sepuluh Nopember, a public engineering university in Surabaya, Indonesia
- Institute of Technological Studies, in Sri Lanka
- Indian Theological Seminary, an interdenominational seminary situated in Chennai, Tamil Nadu, South India
Science and engineering
- Integrated Truss Structure, a component of the International Space Station
- Intelligent transportation system, or intelligent transport systems and services, which add information technology to the transportation infrastructure
- Internal transcribed spacer, a section of DNA located within a set of ribosomal genes
- International Temperature Scale of 1990 (ITS-90), a temperature calibration standard for measurements in units of kelvin and degrees Celsius