Yasu may refer to the following:
- The name for Jesus in some languages including Arabic as spoken by Christians (Yasū' (يَسُوعَ)) and Malayalam (compare to the Hebrew "Yeshua")
- YASU Technologies, a software company in Business Rules Management Domain, located at Hyderabad, India
- Y.A.S.U., Yet Another SecuROM Utility
- Yasu, Fukuoka, a town located in Asakura District, Fukuoka, Japan
- Yasu, Kochi, a former town in Kochi Prefecture, Japan
- Yasu, Shiga, a city located in Shiga, Japan
- Yasu District, Shiga, a former district, now identical with the city
- Yasu River, a river in Shiga Prefecture, Japan
- Yasu (illustrator), a Japanese illustrator
- Yasu (musician), Vocalist for the Japanese bands Janne Da Arc and Acid Black Cherry
- Yasushi Takagi, a fictional character from the anime/manga series NANA