This gene product belongs to the histone deacetylase family. Histone deacetylases act via the formation of large multiprotein complexes and are responsible for the deacetylation of lysine residues on the N-terminal region of the core histones (H2A, H2B, H3 and H4). This protein also forms transcriptional repressor complexes by associating with many different proteins, including YY1, a mammalian zinc-finger transcription factor. Thus it plays an important role in transcriptional regulation, cell cycle progression and developmental events.[2]
Interactions
Histone deacetylase 2 has been shown to interact with:
^ abSchmidt DR, Schreiber SL. "Molecular association between ATR and two components of the nucleosome remodeling and deacetylating complex, HDAC2 and CHD4". Biochemistry38 (44): 14711–7. doi:10.1021/bi991614n. PMID10545197.
^ abcdYoon YM, Baek KH, Jeong SJ, Shin HJ, Ha GH, Jeon AH, Hwang SG, Chun JS, Lee CW. "WD repeat-containing mitotic checkpoint proteins act as transcriptional repressors during interphase". FEBS Lett.575 (1-3): 23–9. doi:10.1016/j.febslet.2004.07.089. PMID15388328.
^ abcdefghijHakimi MA, Dong Y, Lane WS, Speicher DW, Shiekhattar R. "A candidate X-linked mental retardation gene is a component of a new family of histone deacetylase-containing complexes". J. Biol. Chem.278 (9): 7234–9. doi:10.1074/jbc.M208992200. PMID12493763.
^ abcdeTong JK, Hassig CA, Schnitzler GR, Kingston RE, Schreiber SL. "Chromatin deacetylation by an ATP-dependent nucleosome remodelling complex". Nature395 (6705): 917–21. doi:10.1038/27699. PMID9804427.
^ abHakimi MA, Bochar DA, Schmiesing JA, Dong Y, Barak OG, Speicher DW, Yokomori K, Shiekhattar R. "A chromatin remodelling complex that loads cohesin onto human chromosomes". Nature418 (6901): 994–8. doi:10.1038/nature01024. PMID12198550.
^Rountree MR, Bachman KE, Baylin SB. "DNMT1 binds HDAC2 and a new co-repressor, DMAP1, to form a complex at replication foci". Nat. Genet.25 (3): 269–77. doi:10.1038/77023. PMID10888872.
^ abcvan der Vlag J, Otte AP. "Transcriptional repression mediated by the human polycomb-group protein EED involves histone deacetylation". Nat. Genet.23 (4): 474–8. doi:10.1038/70602. PMID10581039.
^Yang WM, Yao YL, Seto E. "The FK506-binding protein 25 functionally associates with histone deacetylases and with transcription factor YY1". EMBO J.20 (17): 4814–25. doi:10.1093/emboj/20.17.4814. PMC: 125595. PMID11532945.
^Wen YD, Cress WD, Roy AL, Seto E. "Histone deacetylase 3 binds to and regulates the multifunctional transcription factor TFII-I". J. Biol. Chem.278 (3): 1841–7. doi:10.1074/jbc.M206528200. PMID12393887.
^ abFischer DD, Cai R, Bhatia U, Asselbergs FA, Song C, Terry R, Trogani N, Widmer R, Atadja P, Cohen D. "Isolation and characterization of a novel class II histone deacetylase, HDAC10". J. Biol. Chem.277 (8): 6656–66. doi:10.1074/jbc.M108055200. PMID11739383.
^ abcYao YL, Yang WM. "The metastasis-associated proteins 1 and 2 form distinct protein complexes with histone deacetylase activity". J. Biol. Chem.278 (43): 42560–8. doi:10.1074/jbc.M302955200. PMID12920132.
^ abcdHakimi MA, Bochar DA, Chenoweth J, Lane WS, Mandel G, Shiekhattar R. "A core-BRAF35 complex containing histone deacetylase mediates repression of neuronal-specific genes". Proc. Natl. Acad. Sci. U.S.A.99 (11): 7420–5. doi:10.1073/pnas.112008599. PMC: 124246. PMID12032298.
^ abJohnson CA, White DA, Lavender JS, O'Neill LP, Turner BM. "Human class I histone deacetylase complexes show enhanced catalytic activity in the presence of ATP and co-immunoprecipitate with the ATP-dependent chaperone protein Hsp70". J. Biol. Chem.277 (11): 9590–7. doi:10.1074/jbc.M107942200. PMID11777905.
^Fischle W, Dequiedt F, Hendzel MJ, Guenther MG, Lazar MA, Voelter W, Verdin E. "Enzymatic activity associated with class II HDACs is dependent on a multiprotein complex containing HDAC3 and SMRT/N-CoR". Mol. Cell9 (1): 45–57. doi:10.1016/s1097-2765(01)00429-4. PMID11804585.
^Fischle W, Dequiedt F, Fillion M, Hendzel MJ, Voelter W, Verdin E. "Human HDAC7 histone deacetylase activity is associated with HDAC3 in vivo". J. Biol. Chem.276 (38): 35826–35. doi:10.1074/jbc.M104935200. PMID11466315.
^Ashburner BP, Westerheide SD, Baldwin AS. "The p65 (RelA) subunit of NF-kappaB interacts with the histone deacetylase (HDAC) corepressors HDAC1 and HDAC2 to negatively regulate gene expression". Mol. Cell. Biol.21 (20): 7065–77. doi:10.1128/MCB.21.20.7065-7077.2001. PMC: 99882. PMID11564889.
^ abcdZhang Y, Ng HH, Erdjument-Bromage H, Tempst P, Bird A, Reinberg D. "Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation". Genes Dev.13 (15): 1924–35. doi:10.1101/gad.13.15.1924. PMC: 316920. PMID10444591.
^Hassig CA, Tong JK, Fleischer TC, Owa T, Grable PG, Ayer DE, Schreiber SL. "A role for histone deacetylase activity in HDAC1-mediated transcriptional repression". Proc. Natl. Acad. Sci. U.S.A.95 (7): 3519–24. doi:10.1073/pnas.95.7.3519. PMC: 19868. PMID9520398.
^Zhang Y, Iratni R, Erdjument-Bromage H, Tempst P, Reinberg D. "Histone deacetylases and SAP18, a novel polypeptide, are components of a human Sin3 complex". Cell89 (3): 357–64. doi:10.1016/s0092-8674(00)80216-0. PMID9150135.
^Wysocka J, Myers MP, Laherty CD, Eisenman RN, Herr W. "Human Sin3 deacetylase and trithorax-related Set1/Ash2 histone H3-K4 methyltransferase are tethered together selectively by the cell-proliferation factor HCF-1". Genes Dev.17 (7): 896–911. doi:10.1101/gad.252103. PMC: 196026. PMID12670868.
^Mazumdar A, Wang RA, Mishra SK, Adam L, Bagheri-Yarmand R, Mandal M, Vadlamudi RK, Kumar R. "Transcriptional repression of oestrogen receptor by metastasis-associated protein 1 corepressor". Nat. Cell Biol.3 (1): 30–7. doi:10.1038/35050532. PMID11146623.
^ abLaherty CD, Yang WM, Sun JM, Davie JR, Seto E, Eisenman RN. "Histone deacetylases associated with the mSin3 corepressor mediate mad transcriptional repression". Cell89 (3): 349–56. doi:10.1016/s0092-8674(00)80215-9. PMID9150134.
^Spronk CA, Tessari M, Kaan AM, Jansen JF, Vermeulen M, Stunnenberg HG, Vuister GW. "The Mad1-Sin3B interaction involves a novel helical fold". Nat. Struct. Biol.7 (12): 1100–4. doi:10.1038/81944. PMID11101889.
^Brackertz M, Boeke J, Zhang R, Renkawitz R. "Two highly related p66 proteins comprise a new family of potent transcriptional repressors interacting with MBD2 and MBD3". J. Biol. Chem.277 (43): 40958–66. doi:10.1074/jbc.M207467200. PMID12183469.
^Ng HH, Zhang Y, Hendrich B, Johnson CA, Turner BM, Erdjument-Bromage H, Tempst P, Reinberg D, Bird A. "MBD2 is a transcriptional repressor belonging to the MeCP1 histone deacetylase complex". Nat. Genet.23 (1): 58–61. doi:10.1038/12659. PMID10471499.
^Iwase S, Januma A, Miyamoto K, Shono N, Honda A, Yanagisawa J, Baba T. "Characterization of BHC80 in BRAF-HDAC complex, involved in neuron-specific gene repression". Biochem. Biophys. Res. Commun.322 (2): 601–8. doi:10.1016/j.bbrc.2004.07.163. PMID15325272.
^Jin Q, van Eynde A, Beullens M, Roy N, Thiel G, Stalmans W, Bollen M. "The protein phosphatase-1 (PP1) regulator, nuclear inhibitor of PP1 (NIPP1), interacts with the polycomb group protein, embryonic ectoderm development (EED), and functions as a transcriptional repressor". J. Biol. Chem.278 (33): 30677–85. doi:10.1074/jbc.M302273200. PMID12788942.
^ abZhang Y, Dufau ML. "Dual mechanisms of regulation of transcription of luteinizing hormone receptor gene by nuclear orphan receptors and histone deacetylase complexes". J. Steroid Biochem. Mol. Biol.85 (2-5): 401–14. doi:10.1016/s0960-0760(03)00230-9. PMID12943729.
^ abcZhang Y, Dufau ML. "Silencing of transcription of the human luteinizing hormone receptor gene by histone deacetylase-mSin3A complex". J. Biol. Chem.277 (36): 33431–8. doi:10.1074/jbc.M204417200. PMID12091390.
^You A, Tong JK, Grozinger CM, Schreiber SL. "CoREST is an integral component of the CoREST- human histone deacetylase complex". Proc. Natl. Acad. Sci. U.S.A.98 (4): 1454–8. doi:10.1073/pnas.98.4.1454. PMC: 29278. PMID11171972.
^Kiernan R, Brès V, Ng RW, Coudart MP, El Messaoudi S, Sardet C, Jin DY, Emiliani S, Benkirane M. "Post-activation turn-off of NF-kappa B-dependent transcription is regulated by acetylation of p65". J. Biol. Chem.278 (4): 2758–66. doi:10.1074/jbc.M209572200. PMID12419806.
^Lai A, Lee JM, Yang WM, DeCaprio JA, Kaelin WG, Seto E, Branton PE. "RBP1 recruits both histone deacetylase-dependent and -independent repression activities to retinoblastoma family proteins". Mol. Cell. Biol.19 (10): 6632–41. PMC: 84642. PMID10490602.
^Zhang Y, Sun ZW, Iratni R, Erdjument-Bromage H, Tempst P, Hampsey M, Reinberg D. "SAP30, a novel protein conserved between human and yeast, is a component of a histone deacetylase complex". Mol. Cell1 (7): 1021–31. doi:10.1016/s1097-2765(00)80102-1. PMID9651585.
^Kuzmichev A, Zhang Y, Erdjument-Bromage H, Tempst P, Reinberg D. "Role of the Sin3-histone deacetylase complex in growth regulation by the candidate tumor suppressor p33(ING1)". Mol. Cell. Biol.22 (3): 835–48. doi:10.1128/mcb.22.3.835-848.2002. PMC: 133546. PMID11784859.
^Fleischer TC, Yun UJ, Ayer DE. "Identification and characterization of three new components of the mSin3A corepressor complex". Mol. Cell. Biol.23 (10): 3456–67. doi:10.1128/mcb.23.10.3456-3467.2003. PMC: 164750. PMID12724404.
^Yang L, Mei Q, Zielinska-Kwiatkowska A, Matsui Y, Blackburn ML, Benedetti D, Krumm AA, Taborsky GJ, Chansky HA. "An ERG (ets-related gene)-associated histone methyltransferase interacts with histone deacetylases 1/2 and transcription co-repressors mSin3A/B". Biochem. J.369 (Pt 3): 651–7. doi:10.1042/BJ20020854. PMC: 1223118. PMID12398767.
^Zhou S, Fujimuro M, Hsieh JJ, Chen L, Hayward SD. "A role for SKIP in EBNA2 activation of CBF1-repressed promoters". J. Virol.74 (4): 1939–47. doi:10.1128/jvi.74.4.1939-1947.2000. PMC: 111672. PMID10644367.
^Vaute O, Nicolas E, Vandel L, Trouche D. "Functional and physical interaction between the histone methyl transferase Suv39H1 and histone deacetylases". Nucleic Acids Res.30 (2): 475–81. doi:10.1093/nar/30.2.475. PMC: 99834. PMID11788710.
^ abWon J, Yim J, Kim TK. "Sp1 and Sp3 recruit histone deacetylase to repress transcription of human telomerase reverse transcriptase (hTERT) promoter in normal human somatic cells". J. Biol. Chem.277 (41): 38230–8. doi:10.1074/jbc.M206064200. PMID12151407.
^ abSun JM, Chen HY, Moniwa M, Litchfield DW, Seto E, Davie JR. "The transcriptional repressor Sp3 is associated with CK2-phosphorylated histone deacetylase 2". J. Biol. Chem.277 (39): 35783–6. doi:10.1074/jbc.C200378200. PMID12176973.
^Tsai SC, Valkov N, Yang WM, Gump J, Sullivan D, Seto E. "Histone deacetylase interacts directly with DNA topoisomerase II". Nat. Genet.26 (3): 349–53. doi:10.1038/81671. PMID11062478.
^Yang WM, Yao YL, Sun JM, Davie JR, Seto E. "Isolation and characterization of cDNAs corresponding to an additional member of the human histone deacetylase gene family". J. Biol. Chem.272 (44): 28001–7. doi:10.1074/jbc.272.44.28001. PMID9346952.
Zhang Y, Dufau ML (2003). "Dual mechanisms of regulation of transcription of luteinizing hormone receptor gene by nuclear orphan receptors and histone deacetylase complexes". J. Steroid Biochem. Mol. Biol.85 (2–5): 401–14. doi:10.1016/S0960-0760(03)00230-9. PMID12943729.
Furukawa Y, Kawakami T, Sudo K, Inazawa J, Matsumine A, Akiyama T, Nakamura Y (1996). "Isolation and mapping of a human gene (RPD3L1) that is homologous to RPD3, a transcription factor in Saccharomyces cerevisiae". Cytogenet. Cell Genet.73 (1–2): 130–3. doi:10.1159/000134323. PMID8646880.
Yang WM, Inouye C, Zeng Y, Bearss D, Seto E (1996). "Transcriptional repression by YY1 is mediated by interaction with a mammalian homolog of the yeast global regulator RPD3". Proc. Natl. Acad. Sci. U.S.A.93 (23): 12845–50. doi:10.1073/pnas.93.23.12845. PMC: 24008. PMID8917507.
Laherty CD, Yang WM, Sun JM, Davie JR, Seto E, Eisenman RN (1997). "Histone deacetylases associated with the mSin3 corepressor mediate mad transcriptional repression". Cell89 (3): 349–56. doi:10.1016/S0092-8674(00)80215-9. PMID9150134.
Zhang Y, Iratni R, Erdjument-Bromage H, Tempst P, Reinberg D (1997). "Histone deacetylases and SAP18, a novel polypeptide, are components of a human Sin3 complex". Cell89 (3): 357–64. doi:10.1016/S0092-8674(00)80216-0. PMID9150135.
Yang WM, Yao YL, Sun JM, Davie JR, Seto E (1997). "Isolation and characterization of cDNAs corresponding to an additional member of the human histone deacetylase gene family". J. Biol. Chem.272 (44): 28001–7. doi:10.1074/jbc.272.44.28001. PMID9346952.
Hassig CA, Tong JK, Fleischer TC, Owa T, Grable PG, Ayer DE, Schreiber SL (1998). "A role for histone deacetylase activity in HDAC1-mediated transcriptional repression". Proc. Natl. Acad. Sci. U.S.A.95 (7): 3519–24. doi:10.1073/pnas.95.7.3519. PMC: 19868. PMID9520398.
Randhawa GS, Bell DW, Testa JR, Feinberg AP (1998). "Identification and mapping of human histone acetylation modifier gene homologues". Genomics51 (2): 262–9. doi:10.1006/geno.1998.5370. PMID9722949.
Zhang Y, LeRoy G, Seelig HP, Lane WS, Reinberg D (1998). "The dermatomyositis-specific autoantigen Mi2 is a component of a complex containing histone deacetylase and nucleosome remodeling activities". Cell95 (2): 279–89. doi:10.1016/S0092-8674(00)81758-4. PMID9790534.
Tong JK, Hassig CA, Schnitzler GR, Kingston RE, Schreiber SL (1998). "Chromatin deacetylation by an ATP-dependent nucleosome remodelling complex". Nature395 (6705): 917–21. doi:10.1038/27699. PMID9804427.
Hsieh JJ, Zhou S, Chen L, Young DB, Hayward SD (1999). "CIR, a corepressor linking the DNA binding factor CBF1 to the histone deacetylase complex". Proc. Natl. Acad. Sci. U.S.A.96 (1): 23–8. doi:10.1073/pnas.96.1.23. PMC: 15086. PMID9874765.
Yarden RI, Brody LC (1999). "BRCA1 interacts with components of the histone deacetylase complex". Proc. Natl. Acad. Sci. U.S.A.96 (9): 4983–8. doi:10.1073/pnas.96.9.4983. PMC: 21803. PMID10220405.
Koipally J, Renold A, Kim J, Georgopoulos K (1999). "Repression by Ikaros and Aiolos is mediated through histone deacetylase complexes". EMBO J.18 (11): 3090–100. doi:10.1093/emboj/18.11.3090. PMC: 1171390. PMID10357820.
Zhang Y, Ng HH, Erdjument-Bromage H, Tempst P, Bird A, Reinberg D (1999). "Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation". Genes Dev.13 (15): 1924–35. doi:10.1101/gad.13.15.1924. PMC: 316920. PMID10444591.
Ng HH, Zhang Y, Hendrich B, Johnson CA, Turner BM, Erdjument-Bromage H, Tempst P, Reinberg D, Bird A (1999). "MBD2 is a transcriptional repressor belonging to the MeCP1 histone deacetylase complex". Nat. Genet.23 (1): 58–61. doi:10.1038/12659. PMID10471499.
Wade PA, Gegonne A, Jones PL, Ballestar E, Aubry F, Wolffe AP (1999). "Mi-2 complex couples DNA methylation to chromatin remodelling and histone deacetylation". Nat. Genet.23 (1): 62–6. doi:10.1038/12664. PMID10471500.
Lai A, Lee JM, Yang WM, DeCaprio JA, Kaelin WG, Seto E, Branton PE (2000). "RBP1 Recruits Both Histone Deacetylase-Dependent and -Independent Repression Activities to Retinoblastoma Family Proteins". Mol. Cell. Biol.19 (10): 6632–41. PMC: 84642. PMID10490602.