Radiation-inducible immediate-early gene IEX-1 is a protein that in humans is encoded by the IER3gene.[3][4]
This gene functions in the protection of cells from Fas- or tumor necrosis factor type alpha-induced apoptosis. Partially degraded and unspliced transcripts are found after virus infection in vitro, but these transcripts are not found in vivo and do not generate a valid protein.[5]
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Kumar R, Kobayashi T, Warner GM, et al. (1999). "A novel immediate early response gene, IEX-1, is induced by ultraviolet radiation in human keratinocytes.". Biochem. Biophys. Res. Commun. 253 (2): 336–41. doi:10.1006/bbrc.1998.9692. PMID9878538.
Schäfer H, Arlt A, Trauzold A, et al. (1999). "The putative apoptosis inhibitor IEX-1L is a mutant nonspliced variant of p22(PRG1/IEX-1) and is not expressed in vivo.". Biochem. Biophys. Res. Commun. 262 (1): 139–45. doi:10.1006/bbrc.1999.1131. PMID10448082.
Feldmann KA, Pittelkow MR, Roche PC, et al. (2001). "Expression of an immediate early gene, IEX-1, in human tissues.". Histochem. Cell Biol. 115 (6): 489–97. doi:10.1007/s004180100284. PMID11455449.
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Im HJ, Craig TA, Pittelkow MR, Kumar R (2002). "Characterization of a novel hexameric repeat DNA sequence in the promoter of the immediate early gene, IEX-1, that mediates 1alpha,25-dihydroxyvitamin D(3)-associated IEX-1 gene repression.". Oncogene. 21 (23): 3706–14. doi:10.1038/sj.onc.1205450. PMID12032839.