Chlorohydroxyphenylglycine
Names
IUPAC name
Amino(2-chloro-5-hydroxyphenyl)acetic acid
Identifiers
170846-74-9 Y
1303993-73-8 (sodium salt) Y
Abbreviations
CHPG
ChemSpider
2879711
1417
Jmol 3D model
Interactive image
PubChem
3645780
InChI=1S/C8H8ClNO3/c9-6-2-1-4(11)3-5(6)7(10)8(12)13/h1-3,7,11H,10H2,(H,12,13)
Key: UNIDAFCQFPGYJJ-UHFFFAOYSA-N
InChI=1/C8H8ClNO3/c9-6-2-1-4(11)3-5(6)7(10)8(12)13/h1-3,7,11H,10H2,(H,12,13)
Key: UNIDAFCQFPGYJJ-UHFFFAOYAM
Properties
C 8 H 6 Cl N O 3
Molar mass
199.59 g·mol−1
Except where otherwise noted, data are given for materials in their
standard state (at 25 °C [77 °F], 100 kPa).
Infobox references
2-Chloro-5-hydroxyphenylglycine or CHPG is an agonist of the metabotropic glutamate receptors , specific for mGluR5 .[1]
It is capable of directly potentiating the depolarization of hippocampal CA1 neurons induced through NMDA administration.[2]
References
Receptor
(ligands )
AMPA
NMDA
Antagonists: Competitive antagonists: AP5 (APV)
AP7
CGP-37849
CGP-39551
CGP-39653
CGP-40116
CGS-19755
CPP
LY-233,053
LY-235,959
LY-274,614
MDL-100,453
Midafotel (d-CPPene)
NPC-12,626
NPC-17,742
PBPD
PEAQX
Perzinfotel
PPDA
SDZ-220581
Selfotel ; Noncompetitive antagonists: ARR-15,896
Caroverine
Dexanabinol
FPL-12495
FR-115,427
Hodgkinsine
Magnesium
MDL-27,266
NPS-1506
Psychotridine
Zinc ; Uncompetitive pore blockers: 2-MDP
3-HO-PCP
3-MeO-PCE
3-MeO-PCMo
3-MeO-PCP
4-MeO-PCP
8A-PDHQ
18-MC
α-Endopsychosin
Alaproclate
Amantadine
Aptiganel
Arketamine
ARL-12,495
ARL-15,896-AR
ARL-16,247
Budipine
Conaridine
Delucemine
Dexoxadrol
Dextrallorphan
Dieticyclidine
Diphenidine
Dizocilpine
Ephenidine
Esketamine
Etoxadrol
Eticyclidine
Fluorolintane
Gacyclidine
Ibogaine
Ibogamine
Indantadol
Ketamine
Ketobemidone
Lanicemine
Loperamide
Memantine
Methadone (Levomethadone )
Methorphan (Dextromethorphan
Levomethorphan )
Methoxetamine
Methoxphenidine
Milnacipran
Morphanol (Dextrorphan
Levorphanol )
NEFA
Neramexane
Nitromemantine
Nitrous oxide
Noribogaine
Norketamine
Orphenadrine
PCPr
Pethidine (meperidine)
Phencyclamine
Phencyclidine
Propoxyphene
Remacemide
Rhynchophylline
Rimantadine
Rolicyclidine
Sabeluzole
Tabernanthine
Tenocyclidine
Tiletamine
Tramadol
Xenon ; Glycine site antagonists: 4-Cl-KYN (AV-101)
5,7-DCKA
7-CKA
ACC
ACEA-1011
ACEA-1328
AV-101
Carisoprodol
CGP-39653
CNQX
DNQX
Felbamate
Gavestinel
GV-196,771
Kynurenic acid
Kynurenine
L-689,560
L-701,324
Licostinel (ACEA-1021)
LU-73,068
MDL-105,519
Meprobamate
MRZ 2/576
PNQX
ZD-9379 ; NR2B subunit antagonists: Besonprodil
CERC-301 (MK-0657)
CO-101,244 (PD-174,494)
Eliprodil
Haloperidol
Ifenprodil
Isoxsuprine
Nylidrin
Ro8-4304
Ro25-6981
Traxoprodil ; Polyamine site antagonists: Arcaine
Co 101676
Diaminopropane
Diethylenetriamine
Huperzine A
Putrescine
Ro 25-6981 ; Unclassified/unsorted antagonists: Bumetanide
Chloroform
Cyclopropane
D -αAA
Diethyl ether
Enflurane
Ethanol
Flufenamic acid
Flupirtine
Furosemide
Halothane
Isoflurane
Metaphit
Methoxyflurane
Niflumic acid
Piretanide
Toluene
Transcrocetin (saffron )
Trichloroethane
Trichloroethanol
Trichloroethylene
Xylene
Kainate
mGlu1
mGlu2
mGlu3
mGlu4
mGlu5
mGlu6
mGlu7
mGlu8
Transporter
(blockers )
Enzyme
(inhibitors )
Others