Macrophage-stimulating protein receptor is a protein that in humans is encoded by the MST1R gene .[5] [6] MST1R is also known as RON (Recepteur d'Origine Nantais) kinase, named after the French city in which it was discovered. It is related to the c-MET receptor tyrosine kinase.[5] [7]
Interactions
MST1R has been shown to interact with Grb2 .[8] [9]
References
^ a b c GRCh38: Ensembl release 89: ENSG00000164078 - Ensembl , May 2017
^ a b c GRCm38: Ensembl release 89: ENSMUSG00000032584 - Ensembl , May 2017
^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ a b Ronsin C, Muscatelli F, Mattei MG, Breathnach R (May 1993). "A novel putative receptor protein tyrosine kinase of the met family". Oncogene . 8 (5): 1195–202. PMID 8386824 .
^ "Entrez Gene: MST1R macrophage stimulating 1 receptor (c-met-related tyrosine kinase)" .
^ Gaudino G, Follenzi A, Naldini L, Collesi C, Santoro M, Gallo KA, Godowski PJ, Comoglio PM (August 1994). "RON is a heterodimeric tyrosine kinase receptor activated by the HGF homologue MSP" . EMBO J . 13 (15): 3524–32. doi :10.1002/j.1460-2075.1994.tb06659.x . PMC 395256 . PMID 8062829 .
^ Li BQ, Wang MH, Kung HF, Ronsin C, Breathnach R, Leonard EJ, Kamata T (November 1995). "Macrophage-stimulating protein activates Ras by both activation and translocation of SOS nucleotide exchange factor" . Biochem. Biophys. Res. Commun . 216 (1): 110–8. doi :10.1006/bbrc.1995.2598 . PMID 7488076 .
^ Iwama A, Yamaguchi N, Suda T (November 1996). "STK/RON receptor tyrosine kinase mediates both apoptotic and growth signals via the multifunctional docking site conserved among the HGF receptor family" . EMBO J . 15 (21): 5866–75. doi :10.1002/j.1460-2075.1996.tb00973.x . PMC 452340 . PMID 8918464 .
Further reading
Li BQ, Wang MH, Kung HF, et al. (1995). "Macrophage-stimulating protein activates Ras by both activation and translocation of SOS nucleotide exchange factor" . Biochem. Biophys. Res. Commun . 216 (1): 110–8. doi :10.1006/bbrc.1995.2598 . PMID 7488076 .
Wang MH, Ronsin C, Gesnel MC, et al. (1994). "Identification of the ron gene product as the receptor for the human macrophage stimulating protein". Science . 266 (5182): 117–9. Bibcode :1994Sci...266..117W . doi :10.1126/science.7939629 . PMID 7939629 .
Gaudino G, Follenzi A, Naldini L, et al. (1994). "RON is a heterodimeric tyrosine kinase receptor activated by the HGF homologue MSP" . EMBO J . 13 (15): 3524–32. doi :10.1002/j.1460-2075.1994.tb06659.x . PMC 395256 . PMID 8062829 .
Lee ST, Strunk KM, Spritz RA (1993). "A survey of protein tyrosine kinase mRNAs expressed in normal human melanocytes". Oncogene . 8 (12): 3403–10. PMID 8247543 .
Collesi C, Santoro MM, Gaudino G, Comoglio PM (1996). "A splicing variant of the RON transcript induces constitutive tyrosine kinase activity and an invasive phenotype" . Mol. Cell. Biol . 16 (10): 5518–26. doi :10.1128/MCB.16.10.5518 . PMC 231551 . PMID 8816464 .
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery" . Genome Res . 6 (9): 791–806. doi :10.1101/gr.6.9.791 . PMID 8889548 .
Iwama A, Yamaguchi N, Suda T (1997). "STK/RON receptor tyrosine kinase mediates both apoptotic and growth signals via the multifunctional docking site conserved among the HGF receptor family" . EMBO J . 15 (21): 5866–75. doi :10.1002/j.1460-2075.1996.tb00973.x . PMC 452340 . PMID 8918464 .
Sakamoto O, Iwama A, Amitani R, et al. (1997). "Role of macrophage-stimulating protein and its receptor, RON tyrosine kinase, in ciliary motility" . J. Clin. Invest . 99 (4): 701–9. doi :10.1172/JCI119214 . PMC 507853 . PMID 9045873 .
Follenzi A, Bakovic S, Gual P, et al. (2000). "Cross-talk between the proto-oncogenes Met and Ron" . Oncogene . 19 (27): 3041–9. doi :10.1038/sj.onc.1203620 . PMID 10871856 .
Chen YQ, Zhou YQ, Fisher JH, Wang MH (2002). "Targeted expression of the receptor tyrosine kinase RON in distal lung epithelial cells results in multiple tumor formation: oncogenic potential of RON in vivo" . Oncogene . 21 (41): 6382–6. doi :10.1038/sj.onc.1205783 . PMID 12214279 .
Chen YQ, Zhou YQ, Fu LH, et al. (2002). "Multiple pulmonary adenomas in the lung of transgenic mice overexpressing the RON receptor tyrosine kinase. Recepteur d'origine nantais" . Carcinogenesis . 23 (11): 1811–9. doi :10.1093/carcin/23.11.1811 . PMID 12419829 .
Zhou YQ, He C, Chen YQ, et al. (2003). "Altered expression of the RON receptor tyrosine kinase in primary human colorectal adenocarcinomas: generation of different splicing RON variants and their oncogenic potential" . Oncogene . 22 (2): 186–97. doi :10.1038/sj.onc.1206075 . PMID 12527888 .
Danilkovitch-Miagkova A, Duh FM, Kuzmin I, et al. (2003). "Hyaluronidase 2 negatively regulates RON receptor tyrosine kinase and mediates transformation of epithelial cells by jaagsiekte sheep retrovirus" . Proc. Natl. Acad. Sci. U.S.A . 100 (8): 4580–5. Bibcode :2003PNAS..100.4580D . doi :10.1073/pnas.0837136100 . PMC 153598 . PMID 12676986 .
Rampino T, Gregorini M, Soccio G, et al. (2003). "The Ron proto-oncogene product is a phenotypic marker of renal oncocytoma". Am. J. Surg. Pathol . 27 (6): 779–85. doi :10.1097/00000478-200306000-00008 . PMID 12766581 . S2CID 21112098 .
Penengo L, Rubin C, Yarden Y, Gaudino G (2003). "c-Cbl is a critical modulator of the Ron tyrosine kinase receptor" . Oncogene . 22 (24): 3669–79. doi :10.1038/sj.onc.1206585 . PMID 12802274 .
Maggiora P, Lorenzato A, Fracchioli S, et al. (2003). "The RON and MET oncogenes are co-expressed in human ovarian carcinomas and cooperate in activating invasiveness". Exp. Cell Res . 288 (2): 382–9. doi :10.1016/S0014-4827(03)00250-7 . PMID 12915129 .
Santoro MM, Gaudino G, Marchisio PC (2003). "The MSP receptor regulates alpha6beta4 and alpha3beta1 integrins via 14-3-3 proteins in keratinocyte migration" . Dev. Cell . 5 (2): 257–71. doi :10.1016/S1534-5807(03)00201-6 . PMID 12919677 .
Angeloni D, Danilkovitch-Miagkova A, Miagkov A, et al. (2004). "The soluble sema domain of the RON receptor inhibits macrophage-stimulating protein-induced receptor activation" . J. Biol. Chem . 279 (5): 3726–32. doi :10.1074/jbc.M309342200 . PMID 14597639 .
van den Akker E, van Dijk T, Parren-van Amelsvoort M, et al. (2004). "Tyrosine kinase receptor RON functions downstream of the erythropoietin receptor to induce expansion of erythroid progenitors". Blood . 103 (12): 4457–65. doi :10.1182/blood-2003-08-2713 . PMID 14982882 .
Raeppel S, Gaudette G, et al. (2010). "Identification of a novel series of potent RON receptor tyrosine kinase inhibitors". Bioorg. Med. Chem. Lett . 20 (9): 2745–9. doi :10.1016/j.bmcl.2010.03.073 . PMID 20363625 .
Activity Regulation Classification Kinetics Types
Angiopoietin CNTF EGF (ErbB)
FGF
FGFR1 FGFR2
Agonists: Ersofermin
FGF (1 , 2 (bFGF) , 3 , 4 , 5 , 6 , 7 (KGF ), 8 , 9 , 10 (KGF2) , 17 , 18 , 22 )
Palifermin
Repifermin
Selpercatinib
Sprifermin
Trafermin
FGFR3 FGFR4 Unsorted
HGF (c-Met) IGF
LNGF (p75NTR ) PDGF RET (GFL)
SCF (c-Kit) TGFβ Trk
TrkA
Negative allosteric modulators: VM-902A
TrkB
Agonists: 3,7-DHF
3,7,8,2'-THF
4'-DMA-7,8-DHF
7,3'-DHF
7,8-DHF
7,8,2'-THF
7,8,3'-THF
Amitriptyline
BDNF
BNN-20
Deoxygedunin
Deprenyl
Diosmetin
DMAQ-B1
HIOC
LM22A-4
N-Acetylserotonin
NT-3
NT-4
Norwogonin (5,7,8-THF)
R7
R13
TDP6
TrkC
VEGF Others
Additional growth factors: Adrenomedullin
Colony-stimulating factors (see here instead)
Connective tissue growth factor (CTGF)
Ephrins (A1 , A2 , A3 , A4 , A5 , B1 , B2 , B3 )
Erythropoietin (see here instead)
Glucose-6-phosphate isomerase (GPI; PGI, PHI, AMF)
Glia maturation factor (GMF)
Hepatoma-derived growth factor (HDGF)
Interleukins /T-cell growth factors (see here instead)
Leukemia inhibitory factor (LIF)
Macrophage-stimulating protein (MSP; HLP, HGFLP)
Midkine (NEGF2)
Migration-stimulating factor (MSF; PRG4)
Oncomodulin
Pituitary adenylate cyclase-activating peptide (PACAP)
Pleiotrophin
Renalase
Thrombopoietin (see here instead)
Wnt signaling proteins
Additional growth factor receptor modulators: Cerebrolysin (neurotrophin mixture)