The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins and other transmembrane 4 superfamily proteins. It is involved in cellular processes including cell adhesion and may regulate integrin trafficking and/or function. This protein enhances cell motility, invasion and metastasis of cancer cells. Multiple alternatively spliced transcript variants that encode the same protein have been described for this gene.[5] Abnormalities in CD151 have been implicated in a form of epidermolysis bullosa.[6][7]
Interactions
Fibrosarcoma cells, reportedly stained with an antibody binding to CD151 (green) and a dye for the nucleus (blue).
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Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID9373149.
Fitter S, Seldin MF, Ashman LK (1998). "Characterisation of the mouse homologue of CD151 (PETA-3/SFA-1); genomic structure, chromosomal localisation and identification of 2 novel splice forms". Biochim. Biophys. Acta. 1398 (1): 75–85. doi:10.1016/S0167-4781(98)00034-7. PMID9602068.
Sincock PM, Fitter S, Parton RG, Berndt MC, Gamble JR, Ashman LK (1999). "PETA-3/CD151, a member of the transmembrane 4 superfamily, is localised to the plasma membrane and endocytic system of endothelial cells, associates with multiple integrins and modulates cell function". J. Cell Sci. 112 ( Pt 6) (6): 833–44. doi:10.1242/jcs.112.6.833. hdl:2440/8940. PMID10036233.
Testa JE, Brooks PC, Lin JM, Quigley JP (1999). "Eukaryotic expression cloning with an antimetastatic monoclonal antibody identifies a tetraspanin (PETA-3/CD151) as an effector of human tumor cell migration and metastasis". Cancer Res. 59 (15): 3812–20. PMID10447000.
Kohno M, Hasegawa H, Miyake M, Yamamoto T, Fujita S (2002). "CD151 enhances cell motility and metastasis of cancer cells in the presence of focal adhesion kinase". Int. J. Cancer. 97 (3): 336–43. doi:10.1002/ijc.1605. PMID11774285. S2CID46569418.