Protein-coding gene in the species Homo sapiens
Transcription factor jun-B is a protein that in humans is encoded by the JUNB gene .[5] [6] Transcription factor jun-B is a transcription factor involved in regulating gene activity following the primary growth factor response. It binds to the DNA sequence 5'-TGA[CG]TCA-3'.
Interactions
JUNB has been shown to interact with
See also
References
^ a b c GRCh38: Ensembl release 89: ENSG00000171223 - Ensembl , May 2017
^ a b c GRCm38: Ensembl release 89: ENSMUSG00000052837 - Ensembl , May 2017
^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Schütte J, Viallet J, Nau M, Segal S, Fedorko J, Minna J (Feb 1990). "jun-B inhibits and c-fos stimulates the transforming and trans-activating activities of c-jun" . Cell . 59 (6): 987–997. doi :10.1016/0092-8674(89)90755-1 . PMID 2513129 .
^ "Entrez Gene: JUNB jun B proto-oncogene" .
^ Hu YF, Li R (Jun 2002). "JunB potentiates function of BRCA1 activation domain 1 (AD1) through a coiled-coil-mediated interaction" . Genes Dev . 16 (12): 1509–17. doi :10.1101/gad.995502 . PMC 186344 . PMID 12080089 .
^ Liberati NT, Datto MB, Frederick JP, Shen X, Wong C, Rougier-Chapman EM, Wang XF (Apr 1999). "Smads bind directly to the Jun family of AP-1 transcription factors" . Proc. Natl. Acad. Sci. U.S.A . 96 (9): 4844–9. Bibcode :1999PNAS...96.4844L . doi :10.1073/pnas.96.9.4844 . PMC 21779 . PMID 10220381 .
Further reading
Hsu JC, Bravo R, Taub R (1992). "Interactions among LRF-1, JunB, c-Jun, and c-Fos define a regulatory program in the G1 phase of liver regeneration" . Mol. Cell. Biol . 12 (10): 4654–65. doi :10.1128/MCB.12.10.4654 . PMC 360392 . PMID 1406655 .
Zafarullah M, Martel-Pelletier J, Cloutier JM, Gedamu L, Pelletier JP (1992). "Expression of c-fos, c-jun, jun-B, metallothionein and metalloproteinase genes in human chondrocyte" . FEBS Lett . 306 (2–3): 169–172. doi :10.1016/0014-5793(92)80992-P . PMID 1633872 . S2CID 43460076 .
Mollinedo F, Vaquerizo MJ, Naranjo JR (1991). "Expression of c-jun, jun B and jun D proto-oncogenes in human peripheral-blood granulocytes" . Biochem. J . 273(Pt 2) (2): 477–9. doi :10.1042/bj2730477 . PMC 1149869 . PMID 1899335 .
Nomura N, Ide M, Sasamoto S, Matsui M, Date T, Ishizaki R (1990). "Isolation of human cDNA clones of jun-related genes, jun-B and jun-D" . Nucleic Acids Res . 18 (10): 3047–3048. doi :10.1093/nar/18.10.3047 . PMC 330838 . PMID 2112242 .
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene . 138 (1–2): 171–174. doi :10.1016/0378-1119(94)90802-8 . PMID 8125298 .
Trask B, Fertitta A, Christensen M, Youngblom J, Bergmann A, Copeland A, de Jong P, Mohrenweiser H, Olsen A, Carrano A (1993). "Fluorescence in situ hybridization mapping of human chromosome 19: cytogenetic band location of 540 cosmids and 70 genes or DNA markers" . Genomics . 15 (1): 133–145. doi :10.1006/geno.1993.1021 . PMID 8432525 .
Phinney DG, Tseng SW, Ryder K (1996). "Complex genetic organization of junB: multiple blocks of flanking evolutionarily conserved sequence at the murine and human junB loci". Genomics . 28 (2): 228–234. doi :10.1006/geno.1995.1135 . PMID 8530030 .
Dorsey MJ, Tae HJ, Sollenberger KG, Mascarenhas NT, Johansen LM, Taparowsky EJ (1996). "B-ATF: a novel human bZIP protein that associates with members of the AP-1 transcription factor family". Oncogene . 11 (11): 2255–65. PMID 8570175 .
Neyns B, Vermeij J, Bourgain C, Vandamme B, Amfo K, Lissens W, DeSutter P, Hooghe-Peters E, DeGrève J (1996). "Expression of the jun family of genes in human ovarian cancer and normal ovarian surface epithelium". Oncogene . 12 (6): 1247–57. PMID 8649827 .
Mendelson KG, Contois LR, Tevosian SG, Davis RJ, Paulson KE (1996). "Independent regulation of JNK/p38 mitogen-activated protein kinases by metabolic oxidative stress in the liver" . Proc. Natl. Acad. Sci. U.S.A . 93 (23): 12908–12913. Bibcode :1996PNAS...9312908M . doi :10.1073/pnas.93.23.12908 . PMC 24019 . PMID 8917518 .
Aronheim A, Zandi E, Hennemann H, Elledge SJ, Karin M (1997). "Isolation of an AP-1 repressor by a novel method for detecting protein-protein interactions" . Mol. Cell. Biol . 17 (6): 3094–102. doi :10.1128/mcb.17.6.3094 . PMC 232162 . PMID 9154808 .
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene . 200 (1–2): 149–156. doi :10.1016/S0378-1119(97)00411-3 . PMID 9373149 .
Fuchs SY, Xie B, Adler V, Fried VA, Davis RJ, Ronai Z (1998). "c-Jun NH2-terminal kinases target the ubiquitination of their associated transcription factors" . J. Biol. Chem . 272 (51): 32163–32168. doi :10.1074/jbc.272.51.32163 . PMID 9405416 .
Venugopal R, Jaiswal AK (1999). "Nrf2 and Nrf1 in association with Jun proteins regulate antioxidant response element-mediated expression and coordinated induction of genes encoding detoxifying enzymes" . Oncogene . 17 (24): 3145–3156. doi :10.1038/sj.onc.1202237 . PMID 9872330 .
Li B, Tournier C, Davis RJ, Flavell RA (1999). "Regulation of IL-4 expression by the transcription factor JunB during T helper cell differentiation" . EMBO J . 18 (2): 420–432. doi :10.1093/emboj/18.2.420 . PMC 1171136 . PMID 9889198 .
Liberati NT, Datto MB, Frederick JP, Shen X, Wong C, Rougier-Chapman EM, Wang XF (1999). "Smads bind directly to the Jun family of AP-1 transcription factors" . Proc. Natl. Acad. Sci. U.S.A . 96 (9): 4844–4849. Bibcode :1999PNAS...96.4844L . doi :10.1073/pnas.96.9.4844 . PMC 21779 . PMID 10220381 .
Chen P, Flory E, Avots A, Jordan BW, Kirchhoff F, Ludwig S, Rapp UR (2000). "Transactivation of naturally occurring HIV-1 long terminal repeats by the JNK signaling pathway. The most frequent naturally occurring length polymorphism sequence introduces a novel binding site for AP-1 factors" . J. Biol. Chem . 275 (27): 20382–20390. doi :10.1074/jbc.M001149200 . PMID 10764760 .
Echlin DR, Tae HJ, Mitin N, Taparowsky EJ (2000). "B-ATF functions as a negative regulator of AP-1 mediated transcription and blocks cellular transformation by Ras and Fos" . Oncogene . 19 (14): 1752–1763. doi :10.1038/sj.onc.1203491 . PMID 10777209 .
Verrecchia F, Pessah M, Atfi A, Mauviel A (2000). "Tumor necrosis factor-alpha inhibits transforming growth factor-beta /Smad signaling in human dermal fibroblasts via AP-1 activation" . J. Biol. Chem . 275 (39): 30226–30231. doi :10.1074/jbc.M005310200 . PMID 10903323 .
Singh K, Camera E, Krug L, Basu A, Pandey RK, Munir S, Wlaschek M, Kochanek S, Schorpp-Kistner M, Picardo M, Angel P, Niemann C, Maity P, Scharffetter-Kochanek K (2018). "JunB defines functional and structural integrity of the epidermo-pilosebaceous unit in the skin" . Nature . 9 (1). doi :10.1038/s41467-018-05726-z . PMID 30143626 .
External links
This article incorporates text from the United States National Library of Medicine , which is in the public domain .
(1) Basic domains
(1.1) Basic leucine zipper (bZIP )(1.2) Basic helix-loop-helix (bHLH )
Group A Group B Group C bHLH-PAS Group D Group E Group F bHLH-COE
(1.3) bHLH-ZIP (1.4) NF-1 (1.5) RF-X (1.6) Basic helix-span-helix (bHSH)
(2) Zinc finger DNA-binding domains
(2.1) Nuclear receptor (Cys4 )
subfamily 1 subfamily 2 subfamily 3 subfamily 4 subfamily 5 subfamily 6 subfamily 0
(2.2) Other Cys4 (2.3) Cys2 His2 (2.4) Cys6 (2.5) Alternating composition (2.6) WRKY
(4) β-Scaffold factors with minor groove contacts
(0) Other transcription factors