Protein KIBRA also known as kidney and brain expressed protein (KIBRA) or WW domain-containing protein 1 (WWC1) is a protein that in humans is encoded by the WWC1gene.[5][6][7]
A single nucleotide polymorphism (rs17070145) [8] in the gene has been associated with human memory performance in one 2006 study.[9] While no significant support for KIBRA's association with memory was found in a 2008 study with 584 subjects,[10] the original 2006 study was replicated in a smaller sample of an elderly population in 2008.[11] A subsequent study in 2009 in two large UK samples indicated that KIBRA is specifically associated with forgetting of non-semantic material.[12]
KIBRA has at least 10 interaction partners, including synaptopodin, PKCζ and Dendrin, most of which modify synaptic plasticity.
For instance, Dendrin is a post-synaptic protein with expression regulated by sleep deprivation.[14]KIBRA has been shown to interact with Protein kinase Mζ.[15]
^Papassotiropoulos A, Stephan DA, Huentelman MJ, Hoerndli FJ, Craig DW, Pearson JV, Huynh KD, Brunner F, Corneveaux J, Osborne D, Wollmer MA, Aerni A, Coluccia D, Hänggi J, Mondadori CR, Buchmann A, Reiman EM, Caselli RJ, Henke K, de Quervain DJ (October 2006). "Common Kibra alleles are associated with human memory performance". Science. 314 (5798): 475–8. Bibcode:2006Sci...314..475P. doi:10.1126/science.1129837. PMID17053149.
^Need AC, Attix DK, McEvoy JM, Cirulli ET, Linney KN, Wagoner AP, Gumbs CE, Giegling I, Möller HJ, Francks C, Muglia P, Roses A, Gibson G, Weale ME, Rujescu D, Goldstein DB (July 2008). "Failure to replicate effect of Kibra on human memory in two large cohorts of European origin". American Journal of Medical Genetics. 147B (5): 667–8. doi:10.1002/ajmg.b.30658. hdl:11858/00-001M-0000-0012-C950-9. PMID18205171.
^Schaper K, Kolsch H, Popp J, Wagner M, Jessen F (July 2008). "KIBRA gene variants are associated with episodic memory in healthy elderly". Neurobiol. Aging. 29 (7): 1123–5. doi:10.1016/j.neurobiolaging.2007.02.001. PMID17353070.
^Bates TC, Price JF, Harris SE, Marioni RE, Fowkes FG, Stewart MC, Murray GD, Whalley LJ, Starr JM, Deary IJ (July 2009). "Association of KIBRA and memory". Neurosci. Lett. 458 (3): 140–3. doi:10.1016/j.neulet.2009.04.050. PMID19397951.
^Corneveaux JJ, Liang WS, Reiman EM, Webster JA, Myers AJ, Zismann VL, Joshipura KD, Pearson JV, Hu-Lince D, Craig DW, Coon KD, Dunckley T, Bandy D, Lee W, Chen K, Beach TG, Mastroeni D, Grover A, Ravid R, Sando SB, Aasly JO, Heun R, Jessen F, Kölsch H, Rogers J, Hutton ML, Melquist S, Petersen RC, Alexander GE, Caselli RJ, Papassotiropoulos A, Stephan DA, Huentelman MJ (June 2010). "Evidence for an association between KIBRA and late-onset Alzheimer's disease". Neurobiol. Aging. 31 (6): 901–9. doi:10.1016/j.neurobiolaging.2008.07.014. PMC2913703. PMID18789830.
^Büther K, Plaas C, Barnekow A, Kremerskothen J (May 2004). "KIBRA is a novel substrate for protein kinase Czeta". Biochem. Biophys. Res. Commun. 317 (3): 703–7. doi:10.1016/j.bbrc.2004.03.107. PMID15081397.
Further reading
Need AC, Attix DK, McEvoy JM, Cirulli ET, Linney KN, Wagoner AP, Gumbs CE, Giegling I, Möller HJ, Francks C, Muglia P, Roses A, Gibson G, Weale ME, Rujescu D, Goldstein DB (2008). "Failure to replicate effect of kibra on human memory in two large cohorts of European origin". American Journal of Medical Genetics. 147B (5): 667–8. doi:10.1002/ajmg.b.30658. hdl:11858/00-001M-0000-0012-C950-9. PMID18205171.